GB1412684A - 1-hydrazino-phthalazine hydrochloride - Google Patents
1-hydrazino-phthalazine hydrochlorideInfo
- Publication number
- GB1412684A GB1412684A GB1164473A GB1164473A GB1412684A GB 1412684 A GB1412684 A GB 1412684A GB 1164473 A GB1164473 A GB 1164473A GB 1164473 A GB1164473 A GB 1164473A GB 1412684 A GB1412684 A GB 1412684A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydrazino
- phthalazine
- palladium
- hydrazine
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ZUXNZUWOTSUBMN-UHFFFAOYSA-N hydralazine hydrochloride Chemical compound Cl.C1=CC=C2C(NN)=NN=CC2=C1 ZUXNZUWOTSUBMN-UHFFFAOYSA-N 0.000 title abstract 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 6
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 4
- RPTUSVTUFVMDQK-UHFFFAOYSA-N Hidralazin Chemical compound C1=CC=C2C(NN)=NN=CC2=C1 RPTUSVTUFVMDQK-UHFFFAOYSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 abstract 2
- 239000003054 catalyst Substances 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 229910052763 palladium Inorganic materials 0.000 abstract 2
- UQTJGZYAFKMABR-UHFFFAOYSA-N (4-chlorophthalazin-1-yl)hydrazine Chemical compound C1=CC=C2C(NN)=NN=C(Cl)C2=C1 UQTJGZYAFKMABR-UHFFFAOYSA-N 0.000 abstract 1
- KGLPWQKSKUVKMJ-UHFFFAOYSA-N 2,3-dihydrophthalazine-1,4-dione Chemical compound C1=CC=C2C(=O)NNC(=O)C2=C1 KGLPWQKSKUVKMJ-UHFFFAOYSA-N 0.000 abstract 1
- LGRFSURHDFAFJT-UHFFFAOYSA-N Phthalic anhydride Natural products C1=CC=C2C(=O)OC(=O)C2=C1 LGRFSURHDFAFJT-UHFFFAOYSA-N 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- JHIWVOJDXOSYLW-UHFFFAOYSA-N butyl 2,2-difluorocyclopropane-1-carboxylate Chemical compound CCCCOC(=O)C1CC1(F)F JHIWVOJDXOSYLW-UHFFFAOYSA-N 0.000 abstract 1
- 238000005695 dehalogenation reaction Methods 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 239000012433 hydrogen halide Substances 0.000 abstract 1
- 229910000039 hydrogen halide Inorganic materials 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- QZIQJVCYUQZDIR-UHFFFAOYSA-N mechlorethamine hydrochloride Chemical compound Cl.ClCCN(C)CCCl QZIQJVCYUQZDIR-UHFFFAOYSA-N 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Landscapes
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1412684 1-hydrazino-phthalazine PLIVA PHARMACEUTICAL & CHEMICAL WORKS 9 March 1973 [20 July 1972] 11644/73 Heading C2C 1 -Hydrazino-phthalazine-hydrochloride or its free base is prepared by dehalogenation of 1- hydrazino-4-halo-phthalazine by hydrogenation using a palladium catalyst, preferably in the presence of a binding agent for the hydrogen halide or in the presence of hydrochloric acid. The reaction takes place at a temperature of below 80‹ C. and a pressure of below 15 atm., with a palladium on carbon or palladium/ barium sulphate catalyst. 1 -Hydrazino-4-chloro-phthalazine is prepared by reaction of phthalic anhydride with hydrazine, converting the resulting 1,4-dihydroxyphthalazine to the 1,4-dichloro derivative and reacting the latter with hydrazine.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| YU188372A YU34793B (en) | 1972-07-20 | 1972-07-20 | Process for preparing 1-hydrazino-phthalazine hydrochloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1412684A true GB1412684A (en) | 1975-11-05 |
Family
ID=25555981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1164473A Expired GB1412684A (en) | 1972-07-20 | 1973-03-09 | 1-hydrazino-phthalazine hydrochloride |
Country Status (7)
| Country | Link |
|---|---|
| AT (1) | AT321924B (en) |
| CA (1) | CA992082A (en) |
| CH (1) | CH575399A5 (en) |
| DE (1) | DE2311510A1 (en) |
| FR (1) | FR2193824B3 (en) |
| GB (1) | GB1412684A (en) |
| YU (1) | YU34793B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3277626A (en) * | 1963-10-17 | 1966-10-11 | Dur O Wal National Inc | Double shank adjustable wall tie |
-
1972
- 1972-07-20 YU YU188372A patent/YU34793B/en unknown
-
1973
- 1973-03-05 AT AT190473A patent/AT321924B/en not_active IP Right Cessation
- 1973-03-06 CH CH326173A patent/CH575399A5/xx not_active IP Right Cessation
- 1973-03-08 DE DE19732311510 patent/DE2311510A1/en active Pending
- 1973-03-09 GB GB1164473A patent/GB1412684A/en not_active Expired
- 1973-03-21 CA CA166,640A patent/CA992082A/en not_active Expired
- 1973-05-09 FR FR7316644A patent/FR2193824B3/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2193824B3 (en) | 1976-04-23 |
| FR2193824A1 (en) | 1974-02-22 |
| YU34793B (en) | 1980-03-15 |
| YU188372A (en) | 1979-09-10 |
| DE2311510A1 (en) | 1974-01-31 |
| AT321924B (en) | 1975-04-25 |
| CH575399A5 (en) | 1976-05-14 |
| CA992082A (en) | 1976-06-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |