GB1409415A - Penicillin sulphoxides and their use in preparing delta3-7- substituted amino-descetoxy-cephalosporins - Google Patents

Penicillin sulphoxides and their use in preparing delta3-7- substituted amino-descetoxy-cephalosporins

Info

Publication number
GB1409415A
GB1409415A GB5951671A GB5951671A GB1409415A GB 1409415 A GB1409415 A GB 1409415A GB 5951671 A GB5951671 A GB 5951671A GB 5951671 A GB5951671 A GB 5951671A GB 1409415 A GB1409415 A GB 1409415A
Authority
GB
United Kingdom
Prior art keywords
sulphoxide
penicillin
alkyl
group
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5951671A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gist Brocades NV
Original Assignee
Gist Brocades NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BE787618D priority Critical patent/BE787618A/en
Application filed by Gist Brocades NV filed Critical Gist Brocades NV
Priority to GB5951671A priority patent/GB1409415A/en
Priority to SU1817032A priority patent/SU500754A3/en
Priority to PH13802A priority patent/PH13845A/en
Priority to IE1136/72A priority patent/IE36638B1/en
Priority to RO7200071975A priority patent/RO63401A/en
Priority to IL40143A priority patent/IL40143A/en
Priority to AT704072A priority patent/AT336181B/en
Priority to ES405883A priority patent/ES405883A1/en
Priority to CA149,545A priority patent/CA1014146A/en
Priority to DK406072AA priority patent/DK142174B/en
Priority to HU72GI00000250A priority patent/HU172648B/en
Priority to CH1216172A priority patent/CH576982A5/xx
Priority to SE7210625A priority patent/SE404927B/en
Priority to JP8204972A priority patent/JPS5438117B2/ja
Priority to LU65904A priority patent/LU65904A1/xx
Priority to AR243595A priority patent/AR193426A1/en
Priority to DE2240224A priority patent/DE2240224C3/en
Priority to NO2942/72A priority patent/NO144153C/en
Priority to YU2100/72A priority patent/YU39899B/en
Priority to CS725688A priority patent/CS197212B2/en
Priority to HUGI178A priority patent/HU169534B/hu
Priority to DE2264648*A priority patent/DE2264648A1/en
Priority to FR7229365A priority patent/FR2150785B1/fr
Priority to DD165088A priority patent/DD100263A5/xx
Priority to FI2271/72A priority patent/FI58643C/en
Priority to NLAANVRAGE7211213,A priority patent/NL177597C/en
Priority to NO2262/73A priority patent/NO144152C/en
Priority to AT114575A priority patent/AT336183B/en
Priority to US05/574,365 priority patent/US4003894A/en
Priority to US05/575,024 priority patent/US4035352A/en
Priority to CA228,450A priority patent/CA1026747A/en
Publication of GB1409415A publication Critical patent/GB1409415A/en
Priority to PH20519A priority patent/PH15675A/en
Priority to DK004078A priority patent/DK154564C/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/08—Preparation by forming the ring or condensed ring systems
    • C07D501/10—Preparation by forming the ring or condensed ring systems from compounds containing the penicillin ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

1409415 Silyl derivatives of penicillin sulphoxides GIST-BROCADES NV 15 Aug 1972 [17 Aug 1971 21 Dec 1971] 38637/71 and 59516/71 Heading C3S [Also in Division C2] Compounds IX in which R 1 is hydrogen or a group linked to the nitrogen atom by carbon or sulphur, R 2 is hydrogen, C 1-6 alkyl or phenyl-C 1-6 alkyl or NR 1 R 2 represents an optionally substituted heterocyclic group and R 3 is the group R 4 R 5 R 6 Si- (where R 4 , R 5 and R 6 each is C 1-6 alkyl optionally substituted by Cl or CN, C 5-3 cycloalkyl phenyl, phenyl-C 1-2 alkyl, C 1-6 alkoxy optionally substituted by Cl or MeO, C 1-6 alkylthio, phenoxy, phenoxy-C 1-2 alkoxy, halogen or 6-substituted-amino-penicillenic-sulphoxide-3-carbonyloxy or R 4 and R 5 together with Si form a ring or R 4 and R 6 together represent O or S) are prepared by reacting the corresponding acid with a compound capable of introducing the R 3 group. Compounds IX prepared are the trimethylsilyl and triethylsilyl derivatives of benzylpenicillin sulphoxide; the trimethylsilyl derivatives of 2-ethoxy naphthyl penicillin sulphoxide phthalimido penicillin sulphoxide, and benzenesulpho-amidomethyl penicillin sulphoxide and the compound formed by the reaction of SiBr 4 with benzyl penicillin sulphoxide.
GB5951671A 1971-04-17 1971-12-21 Penicillin sulphoxides and their use in preparing delta3-7- substituted amino-descetoxy-cephalosporins Expired GB1409415A (en)

Priority Applications (34)

Application Number Priority Date Filing Date Title
BE787618D BE787618A (en) 1971-08-17 PROCESS FOR PREPARING HETEROCYCLIC COMPOUNDS
GB5951671A GB1409415A (en) 1971-08-17 1971-12-21 Penicillin sulphoxides and their use in preparing delta3-7- substituted amino-descetoxy-cephalosporins
SU1817032A SU500754A3 (en) 1971-08-17 1972-08-03 The method of obtaining the 7-substituted aminodesacetoxycephalosporan derivatives
PH13802A PH13845A (en) 1971-08-17 1972-08-15 Preparation of 7-substituted amino-desacetoxycephalosporanic
IE1136/72A IE36638B1 (en) 1971-08-17 1972-08-15 Penicillin sulphoxides and their use in preparing delta 3-7-substituted amino-desacetoxycephalosporins
DE2240224A DE2240224C3 (en) 1971-08-17 1972-08-16 Process for the preparation of A3 methyl-cephem-4-carboxylic acids
CS725688A CS197212B2 (en) 1971-08-17 1972-08-16 Method of preparing delta up 3-deacetoxy cephalosporanic acid
AT704072A AT336181B (en) 1971-08-17 1972-08-16 PROCESS FOR THE PREPARATION OF DELTA3-7-ACYLAMIDO-DESACETOXYCEPHALOSPORANIC ACIDS
ES405883A ES405883A1 (en) 1971-08-17 1972-08-16 Penicillin sulphoxides and their use in preparing delta3-7- substituted amino-descetoxy-cephalosporins
CA149,545A CA1014146A (en) 1971-08-17 1972-08-16 Process for the preparation of desacetoxycephalosporins
DK406072AA DK142174B (en) 1971-08-17 1972-08-16 Process for the preparation of 7beta-acylamino-3-methyl-ceph-3-em-4-carboxylic acids or salts thereof.
HU72GI00000250A HU172648B (en) 1971-12-21 1972-08-16 Process for preparing 6-substituted 6-amino-2,2-dimethyl-penam-3-carboxylic anhydrides
CH1216172A CH576982A5 (en) 1971-08-17 1972-08-16
SE7210625A SE404927B (en) 1971-08-17 1972-08-16 PROCESS FOR THE PRODUCTION OF DELTA 3-7-ACYLAMIDO-DESACETOXI-CEPHALOSPORANIC ACID
JP8204972A JPS5438117B2 (en) 1971-08-17 1972-08-16
LU65904A LU65904A1 (en) 1971-08-17 1972-08-16
AR243595A AR193426A1 (en) 1971-08-17 1972-08-16 PROCEDURE FOR THE PREPARATION OF SUBSTITUTED 7-AMINO-DEACETOXYPHALOSPORANIC DERIVATIVES
RO7200071975A RO63401A (en) 1971-08-17 1972-08-16 PROCESS FOR THE PREPARATION OF 7-ACYLAMIDODESACETOXYCBPHALOSPORANIC ACID DERIVATIVES
NO2942/72A NO144153C (en) 1971-08-17 1972-08-16 PROCEDURE FOR PREPARATION OF DELTA3-7-ACYLAMIDO-3-METHYL-CEFEM-4-CARBOXYLIC ACIDS
YU2100/72A YU39899B (en) 1971-08-17 1972-08-16 Process for obtaining 7-substituted aminodeacetoxycephalosporanic acids
IL40143A IL40143A (en) 1971-08-17 1972-08-16 The preparation of cephalosporins from penicillin sulphoxides and new mixed anhydrides of penicillin sulphoxides
HUGI178A HU169534B (en) 1971-08-17 1972-08-16
DE2264648*A DE2264648A1 (en) 1971-08-17 1972-08-16 PENICILLIN SULFOXIDE ANHYDRIDES AND THE METHOD OF MANUFACTURING THEREOF
FR7229365A FR2150785B1 (en) 1971-08-17 1972-08-16
DD165088A DD100263A5 (en) 1971-08-17 1972-08-16
FI2271/72A FI58643C (en) 1971-08-17 1972-08-16 FOERFARANDE FOER FRAMSTAELLNING AV 3-7-ACYLAMIDO-DESACETOXICEFALOSPORANSYROR
NLAANVRAGE7211213,A NL177597C (en) 1971-08-17 1972-08-17 PROCESS FOR PREPARING SUBSTITUTED 7-AMINODESACETOXYCEPHALOSPORIC ACIDS OR THEIR SALTS
NO2262/73A NO144152C (en) 1971-08-17 1973-05-30 6-ACYL-AMINOPENICILLANIC ANHYRIDES USED AS PRESENT IN THE PREPARATION OF THE SIMILAR 7-ACYL-AMINODEACETOXYXYPHALOSPORAN ACIDS
AT114575A AT336183B (en) 1971-12-21 1975-02-17 PROCESS FOR THE PREPARATION OF NEW 6-SUBSTITUTED AMINOPENICILLANIC ACID ANHYDRIDES
US05/574,365 US4003894A (en) 1971-08-17 1975-05-05 Preparation of 7-substituted amino-desacetoxycephalosporanic acid compounds
US05/575,024 US4035352A (en) 1971-04-17 1975-05-06 Preparation of 7-substituted amino-desacetoxycephalosporanic acid compounds
CA228,450A CA1026747A (en) 1971-08-17 1975-06-04 Process for the preparation of heterocyclic compounds
PH20519A PH15675A (en) 1971-08-17 1977-12-06 6-substituted aminopenicillanic acid anhydrides
DK004078A DK154564C (en) 1971-08-17 1978-01-04 & -ACYL-AMINOPENICILLANIC ANHYRIDES USED AS INTERMEDIATES IN THE PREPARATION OF THE SIMILAR 7-ACYL-AMINODESACETOXYCEPHALOSPORANIC ACIDS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB3863771 1971-08-17
GB5951671A GB1409415A (en) 1971-08-17 1971-12-21 Penicillin sulphoxides and their use in preparing delta3-7- substituted amino-descetoxy-cephalosporins

Publications (1)

Publication Number Publication Date
GB1409415A true GB1409415A (en) 1975-10-08

Family

ID=26263869

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5951671A Expired GB1409415A (en) 1971-04-17 1971-12-21 Penicillin sulphoxides and their use in preparing delta3-7- substituted amino-descetoxy-cephalosporins

Country Status (25)

Country Link
JP (1) JPS5438117B2 (en)
AR (1) AR193426A1 (en)
AT (1) AT336181B (en)
BE (1) BE787618A (en)
CA (1) CA1014146A (en)
CH (1) CH576982A5 (en)
CS (1) CS197212B2 (en)
DD (1) DD100263A5 (en)
DE (2) DE2240224C3 (en)
DK (1) DK142174B (en)
ES (1) ES405883A1 (en)
FI (1) FI58643C (en)
FR (1) FR2150785B1 (en)
GB (1) GB1409415A (en)
HU (1) HU169534B (en)
IE (1) IE36638B1 (en)
IL (1) IL40143A (en)
LU (1) LU65904A1 (en)
NL (1) NL177597C (en)
NO (2) NO144153C (en)
PH (2) PH13845A (en)
RO (1) RO63401A (en)
SE (1) SE404927B (en)
SU (1) SU500754A3 (en)
YU (1) YU39899B (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4310459A (en) * 1978-04-03 1982-01-12 Bristol-Myers Company Process for producing carbamoyl substituted penams and carbamoyl substituted cephams from penicillin sulfoxide esters
US4322347A (en) 1978-04-03 1982-03-30 Bristol-Myers Company 2-Carbamoyloxymethyl-penicillin derivatives
US4374982A (en) 1979-11-07 1983-02-22 Bristol-Myers Company Cepham compounds
US4426520A (en) 1978-04-03 1984-01-17 Bristol-Myers Company 3-Carbamoyloxy-cepham-4-carboxylic acid derivatives
US4518773A (en) * 1978-04-03 1985-05-21 Bristol-Myers Company "3-Carbamoyloxy cephalosporins"

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2222094A1 (en) * 1972-05-05 1973-11-15 Hoechst Ag PROCESS FOR THE PRODUCTION OF AMINOACETIDINONES
GB1472866A (en) * 1974-06-12 1977-05-11 Farmaceutici Italia Cephalosporins and intermediates therefor
GB1467355A (en) * 1974-08-07 1977-03-16 Lepetit Spa Preparation of 6-aminopenicillanic acid 7-aminocephalospo ranic acid and derivatives thereof
ES431585A1 (en) * 1974-11-02 1976-11-16 Gema Sa Process for the conversion of 6-aminopenicillanic acid (6-APA) in 7-aminodesacetoxycephalosporanic acid (7-ADCA)
PL94023B1 (en) * 1974-12-18 1977-07-30 Politechnika Gdanska
GB1472864A (en) * 1975-04-05 1977-05-11 Farmaceutici Italia Method of preparing cephalosporins
US4008231A (en) * 1975-09-15 1977-02-15 Eli Lilly And Company Preparation of 3-methoxymethylcephalosporins
IT1063088B (en) * 1976-06-01 1985-02-11 Dobfar Spa AZETIDINONIC DERIVATIVES AND PROCEDURE FOR THE PREPARATION OF CEPHALOSPORINE
IT1124802B (en) * 1979-10-29 1986-05-14 Dobfar Spa BORONATED DERIVATIVES OF 6-PENICILLANIC ACID AND PROCEDURE FOR THEIR PREPARATION
JPS5716006A (en) * 1980-07-03 1982-01-27 Mitsui Toatsu Chem Inc Suspension polymerization of vinyl chloride

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4310459A (en) * 1978-04-03 1982-01-12 Bristol-Myers Company Process for producing carbamoyl substituted penams and carbamoyl substituted cephams from penicillin sulfoxide esters
US4322347A (en) 1978-04-03 1982-03-30 Bristol-Myers Company 2-Carbamoyloxymethyl-penicillin derivatives
US4426520A (en) 1978-04-03 1984-01-17 Bristol-Myers Company 3-Carbamoyloxy-cepham-4-carboxylic acid derivatives
US4518773A (en) * 1978-04-03 1985-05-21 Bristol-Myers Company "3-Carbamoyloxy cephalosporins"
US4374982A (en) 1979-11-07 1983-02-22 Bristol-Myers Company Cepham compounds

Also Published As

Publication number Publication date
CH576982A5 (en) 1976-06-30
FI58643C (en) 1981-03-10
HU169534B (en) 1976-12-28
AT336181B (en) 1977-04-25
CS197212B2 (en) 1980-04-30
LU65904A1 (en) 1974-02-18
NO144152C (en) 1981-07-01
NL7211213A (en) 1973-02-20
SU500754A3 (en) 1976-01-25
YU39899B (en) 1985-06-30
IL40143A0 (en) 1972-10-29
CA1014146A (en) 1977-07-19
DE2240224C3 (en) 1980-04-10
BE787618A (en) 1973-02-16
IE36638B1 (en) 1977-01-19
YU210072A (en) 1982-02-28
DK142174C (en) 1981-02-16
JPS4829795A (en) 1973-04-19
AR193426A1 (en) 1973-04-23
NO144152B (en) 1981-03-23
DE2264648A1 (en) 1974-07-25
ES405883A1 (en) 1977-02-01
PH15675A (en) 1983-03-11
NO144153C (en) 1981-07-01
FR2150785B1 (en) 1976-03-05
ATA704072A (en) 1976-08-15
JPS5438117B2 (en) 1979-11-19
RO63401A (en) 1978-10-15
DE2240224A1 (en) 1973-03-01
NL177597C (en) 1985-10-16
IL40143A (en) 1976-03-31
NO144153B (en) 1981-03-23
PH13845A (en) 1980-10-16
DK142174B (en) 1980-09-15
SE404927B (en) 1978-11-06
FR2150785A1 (en) 1973-04-13
FI58643B (en) 1980-11-28
DE2240224B2 (en) 1979-07-26
DD100263A5 (en) 1973-09-12
IE36638L (en) 1973-02-17

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PE20 Patent expired after termination of 20 years