GB1402037A - Process for preparing nalpha-a1,nepsilon-b2-9-bis-tert.- butyloxycarbonyl insulin - Google Patents
Process for preparing nalpha-a1,nepsilon-b2-9-bis-tert.- butyloxycarbonyl insulinInfo
- Publication number
- GB1402037A GB1402037A GB5801772A GB5801772A GB1402037A GB 1402037 A GB1402037 A GB 1402037A GB 5801772 A GB5801772 A GB 5801772A GB 5801772 A GB5801772 A GB 5801772A GB 1402037 A GB1402037 A GB 1402037A
- Authority
- GB
- United Kingdom
- Prior art keywords
- insulin
- tert
- butyloxycarbonyl
- nepsilon
- nalpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Substances N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 5
- 102000004877 Insulin Human genes 0.000 title abstract 3
- 108090001061 Insulin Proteins 0.000 title abstract 3
- 229940125396 insulin Drugs 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000004026 insulin derivative Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- ISHLCKAQWKBMAU-UHFFFAOYSA-N tert-butyl n-diazocarbamate Chemical compound CC(C)(C)OC(=O)N=[N+]=[N-] ISHLCKAQWKBMAU-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19712162164 DE2162164C2 (de) | 1971-12-15 | 1971-12-15 | Verfahren zur Herstellung von N hoch delta (Al), N hoch epsilon(B29)-Bis-tert.-butyl-oxycarbonyl-insulin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1402037A true GB1402037A (en) | 1975-08-06 |
Family
ID=5828028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5801772A Expired GB1402037A (en) | 1971-12-15 | 1972-12-15 | Process for preparing nalpha-a1,nepsilon-b2-9-bis-tert.- butyloxycarbonyl insulin |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS4867289A (enExample) |
| AT (1) | AT330376B (enExample) |
| BE (1) | BE792817A (enExample) |
| CA (1) | CA988080A (enExample) |
| CH (1) | CH574910A5 (enExample) |
| DE (1) | DE2162164C2 (enExample) |
| FR (1) | FR2163617B1 (enExample) |
| GB (1) | GB1402037A (enExample) |
| NL (1) | NL7216708A (enExample) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7110277A (enExample) * | 1970-07-31 | 1972-02-02 |
-
0
- BE BE792817D patent/BE792817A/xx unknown
-
1971
- 1971-12-15 DE DE19712162164 patent/DE2162164C2/de not_active Expired
-
1972
- 1972-12-08 CA CA158,803A patent/CA988080A/en not_active Expired
- 1972-12-08 NL NL7216708A patent/NL7216708A/xx unknown
- 1972-12-12 JP JP12470772A patent/JPS4867289A/ja active Pending
- 1972-12-12 CH CH1805372A patent/CH574910A5/xx not_active IP Right Cessation
- 1972-12-14 AT AT1065072A patent/AT330376B/de active
- 1972-12-14 FR FR7244555A patent/FR2163617B1/fr not_active Expired
- 1972-12-15 GB GB5801772A patent/GB1402037A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AT330376B (de) | 1976-06-25 |
| JPS4867289A (enExample) | 1973-09-13 |
| DE2162164A1 (enExample) | 1973-03-15 |
| FR2163617A1 (enExample) | 1973-07-27 |
| CA988080A (en) | 1976-04-27 |
| CH574910A5 (enExample) | 1976-04-30 |
| DE2162164C2 (de) | 1973-10-18 |
| FR2163617B1 (enExample) | 1976-10-29 |
| NL7216708A (enExample) | 1973-06-19 |
| BE792817A (fr) | 1973-06-15 |
| ATA1065072A (de) | 1975-09-15 |
| DE2162164B1 (de) | 1973-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |