GB1399578A - Antibiotic xk-62-2 and process for production thereof - Google Patents
Antibiotic xk-62-2 and process for production thereofInfo
- Publication number
- GB1399578A GB1399578A GB2472773A GB2472773A GB1399578A GB 1399578 A GB1399578 A GB 1399578A GB 2472773 A GB2472773 A GB 2472773A GB 2472773 A GB2472773 A GB 2472773A GB 1399578 A GB1399578 A GB 1399578A
- Authority
- GB
- United Kingdom
- Prior art keywords
- micromonospora
- atcc
- antibiotic
- sagamiensis
- var
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
- C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
Abstract
1399578 Antibiotic XK-62-2 and Gentamicin C ABBOTT LABORATORIES and KYOWA HAKKO KOGYO CO Ltd 23 May 1973 [27 May 1972 11 Sept 1972] 24727/73 Headings C2A and C2C The new antibiotic XK-62-2 characterized as a basic white powder forming acid-addition salts ; containing the elements: C = 51À90%, H = 8À81%, N = 15À18% and O = 24À11%; having a mol. wt. of 463 and a molecular formula : C 20 H 41 N 5 O 7 ; a U.V. absorption spectrum as shown in Fig. 1, an I.R. absorption spectrum as shown in Fig. 2 (main absorption peaks at 610, 1040, 1110, 1285, 1340, 1390, 1460, 1510, 1620, 2050, 2920, 3030 and 3350 cm.<SP>-1</SP>), and an NMR spectrum as shown in Fig. 3 ; showing a specific rotation [α]<SP>20</SP> D = + 116 degrees (C = 1, water); and being soluble in water and polar organic solvents, and insoluble in non-polar solvents, is produced by aerobically cultivating a micro-organism of the species Micromonospora sagamiensis which is capable of producing the said antibiotic, or Micromonospora echinospora ATCC 15837, Micromonospora echinospora var. ferruginea ATCC 15836, Micromonospora echinospora var. pallida ATCC 15838 or Micromonospora purpurea ATCC 15835. The antibiotic XK-62-2 probably has the formula Micro-organisms of the species Micromonospora sagamiensis capable of producing the antibiotic are Micromonospora sagamiensis ATCC 21826, Micromonospora sagamiensis var. flava ATCC 21827 and Micromonospora sagamiensis var. nonreducans ATCC 21803. These strains also produce gentamicin C complex antibiotics, and the invention includes a process for producing gentamicin C antibiotics by aerobically cultivating a micro-organism of the species Micromonospora sagamiensis. Gentamicins C 1 , C 2 and C 1a are thus prepared; also the sulphate salts thereof and of antibiotic XK-62-2 are produced.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP47052177A JPS5039155B2 (en) | 1972-05-27 | 1972-05-27 | |
| JP9047772A JPS4947590A (en) | 1972-09-11 | 1972-09-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1399578A true GB1399578A (en) | 1975-07-02 |
Family
ID=26392796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2472773A Expired GB1399578A (en) | 1972-05-27 | 1973-05-23 | Antibiotic xk-62-2 and process for production thereof |
Country Status (6)
| Country | Link |
|---|---|
| AR (1) | AR201918A1 (en) |
| CA (1) | CA1003772A (en) |
| CH (1) | CH568388A5 (en) |
| ES (1) | ES415221A1 (en) |
| FR (1) | FR2189011B1 (en) |
| GB (1) | GB1399578A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5119744A (en) * | 1974-08-05 | 1976-02-17 | Kyowa Hakko Kogyo Kk | Koseibutsushitsu xkk6222 no shinkyudotainoseiho |
| US4298690A (en) * | 1977-05-19 | 1981-11-03 | Kyowa Hakko Kogyo Co., Ltd. | Antibiotics XK-62-3 and XK-62-4 and process for production thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH71A (en) * | 1888-11-15 | 1889-06-13 | Th Hunziker | Apparatus for embroidering elongated needles for hand embroidery machines |
-
1973
- 1973-05-23 AR AR24820473A patent/AR201918A1/en active
- 1973-05-23 GB GB2472773A patent/GB1399578A/en not_active Expired
- 1973-05-25 ES ES415221A patent/ES415221A1/en not_active Expired
- 1973-05-25 CH CH757173A patent/CH568388A5/xx not_active IP Right Cessation
- 1973-05-25 CA CA172,245A patent/CA1003772A/en not_active Expired
- 1973-05-28 FR FR7319330A patent/FR2189011B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2189011B1 (en) | 1976-08-13 |
| ES415221A1 (en) | 1976-08-01 |
| DE2326781A1 (en) | 1973-12-13 |
| AR201918A1 (en) | 1975-04-30 |
| FR2189011A1 (en) | 1974-01-25 |
| CH568388A5 (en) | 1975-10-31 |
| DE2326781B2 (en) | 1975-06-12 |
| AU5620473A (en) | 1974-11-28 |
| CA1003772A (en) | 1977-01-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19920523 |