GB1398023A - Process for producing 6-omega-3,phenyl-pyrrodidyl-1,- propionylbenzo-1,4-dioxane its salts and process for producing same - Google Patents

Process for producing 6-omega-3,phenyl-pyrrodidyl-1,- propionylbenzo-1,4-dioxane its salts and process for producing same

Info

Publication number
GB1398023A
GB1398023A GB4912072A GB4912072A GB1398023A GB 1398023 A GB1398023 A GB 1398023A GB 4912072 A GB4912072 A GB 4912072A GB 4912072 A GB4912072 A GB 4912072A GB 1398023 A GB1398023 A GB 1398023A
Authority
GB
United Kingdom
Prior art keywords
dioxane
salts
propionylbenzo
producing
base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4912072A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INST TOXIKOLOGII MIN ZDRAVOOKH
Original Assignee
INST TOXIKOLOGII MIN ZDRAVOOKH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by INST TOXIKOLOGII MIN ZDRAVOOKH filed Critical INST TOXIKOLOGII MIN ZDRAVOOKH
Publication of GB1398023A publication Critical patent/GB1398023A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1398023 Preparation of 6-w-(3<SP>1</SP>-phenylpyrrolidyl - -1<SP>1</SP>)propionylbenzo - 1,4 - dioxane and salts thereof TNSTITUT TOXIKOLOGII MINISTERSTVA ZDRAVOOKHRANENIA SSSR 25 Oct 1972 [5 June 1972] 49120/72 Heading C2C Salts of 6 - w - (3<SP>1</SP> - phenylpyrrolidyl - 1<SP>1</SP>) propionylbenzo-1,4-dioxane of the formula wherein A is a chlorine-free mineral acid or an organic acid, may be prepared by reacting the base with an appropriate acid. The base starting material is obtained by reacting 3-phenylpyrrolidine with 6-w-dimethylaminopropionylbenzo-1,4-dioxane in the presence of an alkaline agent in an organic solvent medium ; the starting material may be employed in the form of a base or salt and the dimethylamine produced may be removed with an inert gas. The salts possess pharmaceutical properties and exhibit a peripheral and central adreno blocking action.
GB4912072A 1972-06-05 1972-10-25 Process for producing 6-omega-3,phenyl-pyrrodidyl-1,- propionylbenzo-1,4-dioxane its salts and process for producing same Expired GB1398023A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU1788853 1972-06-05

Publications (1)

Publication Number Publication Date
GB1398023A true GB1398023A (en) 1975-06-18

Family

ID=20515461

Family Applications (2)

Application Number Title Priority Date Filing Date
GB4865872A Expired GB1364993A (en) 1972-06-05 1972-10-23 Beta-ketoderivatives of linear and cyclic beta-phenylethylamines salts therefor and processes for producing same
GB4912072A Expired GB1398023A (en) 1972-06-05 1972-10-25 Process for producing 6-omega-3,phenyl-pyrrodidyl-1,- propionylbenzo-1,4-dioxane its salts and process for producing same

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB4865872A Expired GB1364993A (en) 1972-06-05 1972-10-23 Beta-ketoderivatives of linear and cyclic beta-phenylethylamines salts therefor and processes for producing same

Country Status (4)

Country Link
CH (1) CH575944A5 (en)
DE (1) DE2252344A1 (en)
FR (1) FR2247228B1 (en)
GB (2) GB1364993A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0061149A1 (en) * 1981-03-17 1982-09-29 Mitsubishi Kasei Corporation Alkylenedioxybenzene derivatives and acid addition salts thereof and a process for their preparation
CN111909138A (en) * 2019-05-09 2020-11-10 上海仕谱生物科技有限公司 Compounds that inhibit TDG activity

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0061149A1 (en) * 1981-03-17 1982-09-29 Mitsubishi Kasei Corporation Alkylenedioxybenzene derivatives and acid addition salts thereof and a process for their preparation
CN111909138A (en) * 2019-05-09 2020-11-10 上海仕谱生物科技有限公司 Compounds that inhibit TDG activity
WO2020224396A1 (en) * 2019-05-09 2020-11-12 上海仕谱生物科技有限公司 Compounds inhibiting tdg activity
CN114072398A (en) * 2019-05-09 2022-02-18 上海仕谱生物科技有限公司 Compounds that inhibit TDG activity
CN114072398B (en) * 2019-05-09 2024-06-11 上海仕谱生物科技有限公司 Compounds that inhibit TDG activity

Also Published As

Publication number Publication date
FR2247228B1 (en) 1977-04-08
GB1364993A (en) 1974-08-29
DE2252344A1 (en) 1973-12-13
FR2247228A1 (en) 1975-05-09
CH575944A5 (en) 1976-05-31

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee