GB1396235A - Process for the isolation of l-dopa from an aqueous solution - Google Patents
Process for the isolation of l-dopa from an aqueous solutionInfo
- Publication number
- GB1396235A GB1396235A GB3323473A GB3323473A GB1396235A GB 1396235 A GB1396235 A GB 1396235A GB 3323473 A GB3323473 A GB 3323473A GB 3323473 A GB3323473 A GB 3323473A GB 1396235 A GB1396235 A GB 1396235A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dopa
- solution
- isolation
- aqueous solution
- sulphonic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 title abstract 8
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 title abstract 8
- 239000007864 aqueous solution Substances 0.000 title abstract 2
- 238000002955 isolation Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000000243 solution Substances 0.000 abstract 4
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 3
- 239000002244 precipitate Substances 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 238000006386 neutralization reaction Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/28—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from natural products
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Extraction Or Liquid Replacement (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
1396235 L-dopa MEDICA AB OY 12 July 1973 [14 July 1972] 33234/73 Heading C2C A process for the isolation of 3-(3,4-dihydroxyphenyl)-L-alanine (L-dopa) from an aqueous solution wherein the L-dopa is extracted from the solution with the aid of liquid ion exchanger which consists of a sulphonic acid dissolved in an organic solvent and to which the L-dopa is bound in the form of a sulphonic acid salt, from which salt it is liberated by neutralization with a base that precipitates L-dopa, whereafter the precipitate is separated from the solution, which is then regenerated by washing with a mineral acid solution, and the sulphonic acid solution obtained is used again for binding L-dopa.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI722027A FI48673C (en) | 1972-07-14 | 1972-07-14 | Method for isolating 3 (3,4-dihydroxyphenyl) -L-alanine (L-DOPA) from a stock solution. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1396235A true GB1396235A (en) | 1975-06-04 |
Family
ID=8506564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3323473A Expired GB1396235A (en) | 1972-07-14 | 1973-07-12 | Process for the isolation of l-dopa from an aqueous solution |
Country Status (12)
| Country | Link |
|---|---|
| AT (1) | AT320140B (en) |
| CA (1) | CA996575A (en) |
| CH (1) | CH581095A5 (en) |
| DE (1) | DE2333375A1 (en) |
| DK (1) | DK140405B (en) |
| ES (1) | ES416750A1 (en) |
| FI (1) | FI48673C (en) |
| FR (1) | FR2192846B1 (en) |
| GB (1) | GB1396235A (en) |
| NL (1) | NL7309698A (en) |
| NO (1) | NO139683C (en) |
| SE (1) | SE407743B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2943761C2 (en) * | 1979-10-30 | 1983-11-17 | Degussa Ag, 6000 Frankfurt | Process for the isolation of amino acids which contain at least one aromatic or heteroaromatic ring |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2681927A (en) * | 1951-05-04 | 1954-06-22 | Research Corp | Separation of amino acids |
-
1972
- 1972-07-14 FI FI722027A patent/FI48673C/en active
-
1973
- 1973-06-30 DE DE19732333375 patent/DE2333375A1/en active Pending
- 1973-07-10 ES ES416750A patent/ES416750A1/en not_active Expired
- 1973-07-11 AT AT609673A patent/AT320140B/en not_active IP Right Cessation
- 1973-07-12 SE SE7309794A patent/SE407743B/en unknown
- 1973-07-12 NL NL7309698A patent/NL7309698A/xx not_active Application Discontinuation
- 1973-07-12 GB GB3323473A patent/GB1396235A/en not_active Expired
- 1973-07-13 FR FR7325779A patent/FR2192846B1/fr not_active Expired
- 1973-07-13 CA CA176,451A patent/CA996575A/en not_active Expired
- 1973-07-13 CH CH1026773A patent/CH581095A5/xx not_active IP Right Cessation
- 1973-07-13 DK DK389373AA patent/DK140405B/en unknown
- 1973-07-13 NO NO2875/73A patent/NO139683C/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AT320140B (en) | 1975-01-27 |
| CA996575A (en) | 1976-09-07 |
| FR2192846A1 (en) | 1974-02-15 |
| NO139683C (en) | 1979-04-25 |
| CH581095A5 (en) | 1976-10-29 |
| FI48673B (en) | 1974-09-02 |
| NL7309698A (en) | 1974-01-16 |
| FR2192846B1 (en) | 1977-02-25 |
| NO139683B (en) | 1979-01-15 |
| DK140405C (en) | 1980-01-21 |
| ES416750A1 (en) | 1976-02-01 |
| FI48673C (en) | 1974-12-10 |
| SE407743B (en) | 1979-04-23 |
| DE2333375A1 (en) | 1974-01-24 |
| DK140405B (en) | 1979-08-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |