GB1392902A - Aminoesters of cardenolides - Google Patents
Aminoesters of cardenolidesInfo
- Publication number
- GB1392902A GB1392902A GB332773A GB332773A GB1392902A GB 1392902 A GB1392902 A GB 1392902A GB 332773 A GB332773 A GB 332773A GB 332773 A GB332773 A GB 332773A GB 1392902 A GB1392902 A GB 1392902A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- digitoxigenin
- jan
- prepared
- appropriate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001738 cardenolides Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- XZTUSOXSLKTKJQ-UHFFFAOYSA-N Uzarigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C1(O)CCC2C1=CC(=O)OC1 XZTUSOXSLKTKJQ-UHFFFAOYSA-N 0.000 abstract 2
- 235000001014 amino acid Nutrition 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- XZTUSOXSLKTKJQ-CESUGQOBSA-N digitoxigenin Chemical compound C1([C@H]2CC[C@]3(O)[C@H]4[C@@H]([C@]5(CC[C@H](O)C[C@H]5CC4)C)CC[C@@]32C)=CC(=O)OC1 XZTUSOXSLKTKJQ-CESUGQOBSA-N 0.000 abstract 2
- QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 abstract 2
- SNNJOYYRZHOKFM-YQGQCKGGSA-N 3-[(8R,9S,10S,13S,14R,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2H-furan-5-one Chemical class C[C@]12CC[C@H]3[C@@H](CCC4CC(O)CC[C@]34C)[C@H]1CC[C@@H]2C1=CC(=O)OC1 SNNJOYYRZHOKFM-YQGQCKGGSA-N 0.000 abstract 1
- -1 Cardenolide aminoacid esters Chemical class 0.000 abstract 1
- TYYDXNISHGVDGA-UHFFFAOYSA-N Corotoxigenin Natural products CC12CCC3C(CCC4CC(O)CCC34C=O)C1CCC2C5=CC(=O)OC5 TYYDXNISHGVDGA-UHFFFAOYSA-N 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 230000003177 cardiotonic effect Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229940089960 chloroacetate Drugs 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 150000003840 hydrochlorides Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 125000000612 phthaloyl group Chemical group C(C=1C(C(=O)*)=CC=CC1)(=O)* 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1978872A IT1058257B (it) | 1972-01-25 | 1972-01-25 | Amminoesteri di cardenolidi |
| IT2388772A IT1045203B (it) | 1972-05-04 | 1972-05-04 | Amminoesteri di cardenolidi |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1392902A true GB1392902A (en) | 1975-05-07 |
Family
ID=26327305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB332773A Expired GB1392902A (en) | 1972-01-25 | 1973-01-23 | Aminoesters of cardenolides |
Country Status (3)
| Country | Link |
|---|---|
| DE (1) | DE2303602A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2181694B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1392902A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8481721B2 (en) | 2009-05-18 | 2013-07-09 | Telomerase Activation Sciences, Inc. | Compositions and methods for increasing telomerase activity |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2310766A1 (fr) * | 1975-05-16 | 1976-12-10 | Nativelle Sa Ets | Derives de cardenolides, procede de preparation et application a titre de medicament |
-
1973
- 1973-01-23 GB GB332773A patent/GB1392902A/en not_active Expired
- 1973-01-25 DE DE2303602A patent/DE2303602A1/de active Pending
- 1973-01-25 FR FR7302651A patent/FR2181694B1/fr not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8481721B2 (en) | 2009-05-18 | 2013-07-09 | Telomerase Activation Sciences, Inc. | Compositions and methods for increasing telomerase activity |
| US9403866B2 (en) | 2009-05-18 | 2016-08-02 | Telomerase Activation Sciences, Inc. | Compositions and methods for increasing telomerase activity |
| US9913851B2 (en) | 2009-05-18 | 2018-03-13 | Telomerase Activation Sciences, Inc. | Compositions and methods for increasing telomerase activity |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2181694A1 (enrdf_load_stackoverflow) | 1973-12-07 |
| FR2181694B1 (enrdf_load_stackoverflow) | 1976-07-02 |
| DE2303602A1 (de) | 1973-07-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |