GB1391052A - Medicinal use of pyrazolone derivatives - Google Patents

Medicinal use of pyrazolone derivatives

Info

Publication number
GB1391052A
GB1391052A GB2978673A GB2978673A GB1391052A GB 1391052 A GB1391052 A GB 1391052A GB 2978673 A GB2978673 A GB 2978673A GB 2978673 A GB2978673 A GB 2978673A GB 1391052 A GB1391052 A GB 1391052A
Authority
GB
United Kingdom
Prior art keywords
amino
pyrazol
alkyl
diluent
admixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2978673A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of GB1391052A publication Critical patent/GB1391052A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
    • C07D231/52—Oxygen atom in position 3 and nitrogen atom in position 5, or vice versa

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1391052 Pyrazolone derivatives BAYER AG 22 June 1973 [23 June 1972] 29786/73 Heading A5B A pharmaceutical composition contains as an active ingredient a compound which is a 3-amino-pyrazol-5-one of general formula: or its salt in which R is an aryl radical which carries either no substituents or the following substituents, (a) 1, 2 or 3 identical or different substituents selected from halogen, trifluoromethyl, alkyl, phenyl, alkoxy, and alkenoxy groups; or (b) one alkylamino, dialkylamino, trifluoromethoxy, nitro, nitrile, carbonamido, sulphonamido or SO n -Alkyl (n=0, 1 or 2) group and optionally also 1 or 2 substituents selected from alkyl, alkoxy, halogen and trifluoromethyl groups; or (c) an annellated branched or unbranched, saturated or unsaturated 5-, 6- or 7-membered-isocyclic or heterocyclic ring (which latter ring can optionally contain 1 or 2 oxygen andlor sulphur atoms) in admixture with a solid or liquefied gaseous diluent or in admixture with a liquid diluent other than a solvent of a molecular weight less than 200 except in the presence of a surface active agent. The active ingredient may be in the form of its sodium, potassium, ethanolamine, diethanolamine, triethanolamine, amino-tris-hydroxymethyl-methane, glucosamine or N-methyl-glucosamine salt. The compound may be used in the form of a sterile or isotonic solution. It may also be used with or without a diluent, as a medicament and in the form of tablets, pills, dragees, capsules, ampoules or suppositories. Suitable compounds exemplified are 3-aminol-(4-chlorobenzyl)-pyrazole- 5 - one, 3-amino- 1-(4-bromobenzyl)-pyrazol-5-one and 3-amino- 1-(3, 4-dimethylbenzyl)-pyrazol-5-one.
GB2978673A 1972-06-23 1973-06-22 Medicinal use of pyrazolone derivatives Expired GB1391052A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2230675A DE2230675A1 (en) 1972-06-23 1972-06-23 DIURETIC AND ANTIHYPERTENSIVE AGENT

Publications (1)

Publication Number Publication Date
GB1391052A true GB1391052A (en) 1975-04-16

Family

ID=5848526

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2978673A Expired GB1391052A (en) 1972-06-23 1973-06-22 Medicinal use of pyrazolone derivatives

Country Status (9)

Country Link
BE (1) BE801227A (en)
DE (1) DE2230675A1 (en)
FR (1) FR2189071B1 (en)
GB (1) GB1391052A (en)
IE (1) IE37835B1 (en)
IL (1) IL42562A (en)
LU (1) LU67748A1 (en)
NL (1) NL7308648A (en)
ZA (1) ZA734240B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2319278C2 (en) * 1973-04-17 1986-02-20 Bayer Ag, 5090 Leverkusen Pharmaceutical agent
USRE30420E (en) * 1973-04-17 1980-10-21 Bayer Aktiengesellschaft Pyrazol-5-ones
US4081596A (en) * 1973-04-17 1978-03-28 Bayer Aktiengesellschaft Pyrazol-5-ones

Also Published As

Publication number Publication date
AU5720073A (en) 1975-01-09
BE801227A (en) 1973-12-21
ZA734240B (en) 1974-05-29
DE2230675A1 (en) 1974-01-10
NL7308648A (en) 1973-12-27
FR2189071A1 (en) 1974-01-25
LU67748A1 (en) 1973-08-16
IE37835L (en) 1973-12-23
IE37835B1 (en) 1977-10-26
IL42562A (en) 1977-05-31
FR2189071B1 (en) 1977-09-09
IL42562A0 (en) 1973-08-29

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee