GB1389525A - Anthelmintic phosphonoureido compounds - Google Patents
Anthelmintic phosphonoureido compoundsInfo
- Publication number
- GB1389525A GB1389525A GB2615073A GB2615073A GB1389525A GB 1389525 A GB1389525 A GB 1389525A GB 2615073 A GB2615073 A GB 2615073A GB 2615073 A GB2615073 A GB 2615073A GB 1389525 A GB1389525 A GB 1389525A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- arylene
- ureido
- phosphonoureido
- acylthioureido
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 phosphonoureido compounds Chemical class 0.000 title abstract 5
- 230000000507 anthelmentic effect Effects 0.000 title abstract 3
- 125000000732 arylene group Chemical group 0.000 abstract 3
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 abstract 3
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- WJFKNYWRSNBZNX-UHFFFAOYSA-N 10H-phenothiazine Chemical compound C1=CC=C2NC3=CC=CC=C3SC2=C1 WJFKNYWRSNBZNX-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- HLFSDGLLUJUHTE-SNVBAGLBSA-N Levamisole Chemical compound C1([C@H]2CN3CCSC3=N2)=CC=CC=C1 HLFSDGLLUJUHTE-SNVBAGLBSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 229940124339 anthelmintic agent Drugs 0.000 abstract 1
- 239000000921 anthelmintic agent Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229950004965 bunamidine Drugs 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229960001614 levamisole Drugs 0.000 abstract 1
- FGGFIMIICGZCCJ-UHFFFAOYSA-N n,n-dibutyl-4-hexoxynaphthalene-1-carboximidamide Chemical compound C1=CC=C2C(OCCCCCC)=CC=C(C(=N)N(CCCC)CCCC)C2=C1 FGGFIMIICGZCCJ-UHFFFAOYSA-N 0.000 abstract 1
- RJMUSRYZPJIFPJ-UHFFFAOYSA-N niclosamide Chemical compound OC1=CC=C(Cl)C=C1C(=O)NC1=CC=C([N+]([O-])=O)C=C1Cl RJMUSRYZPJIFPJ-UHFFFAOYSA-N 0.000 abstract 1
- 229960001920 niclosamide Drugs 0.000 abstract 1
- 229950000688 phenothiazine Drugs 0.000 abstract 1
- 229960005141 piperazine Drugs 0.000 abstract 1
- 229960005134 pyrantel Drugs 0.000 abstract 1
- YSAUAVHXTIETRK-AATRIKPKSA-N pyrantel Chemical compound CN1CCCN=C1\C=C\C1=CC=CS1 YSAUAVHXTIETRK-AATRIKPKSA-N 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- WJCNZQLZVWNLKY-UHFFFAOYSA-N thiabendazole Chemical compound S1C=NC(C=2NC3=CC=CC=C3N=2)=C1 WJCNZQLZVWNLKY-UHFFFAOYSA-N 0.000 abstract 1
- 229960004546 thiabendazole Drugs 0.000 abstract 1
- 235000010296 thiabendazole Nutrition 0.000 abstract 1
- 239000004308 thiabendazole Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
- C07C331/16—Isothiocyanates
- C07C331/32—Isothiocyanates having isothiocyanate groups acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2479—Compounds containing the structure P(=X)n-N-acyl, P(=X)n-N-heteroatom, P(=X)n-N-CN (X = O, S, Se; n = 0, 1)
- C07F9/2487—Compounds containing the structure P(=X)n-N-acyl, P(=X)n-N-heteroatom, P(=X)n-N-CN (X = O, S, Se; n = 0, 1) containing the structure P(=X)n-N-C(=X) (X = O, S, Se; n = 0, 1)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
1389525 Anthelmintics ROHM & HAAS CO 1 June 1973 [5 June 1972] 26150/73 Heading A5B [Also in Division C2] An anthelmintic composition comprises, together with a suitable carrier, an arylene compound whose free valencies are satisfied by (1) a phosphonoureido or phosphonothioureido group attached to the arylene nucleus through a free valence of the ureido group and (2) an amino group or an acylureido or acylthioureido group attached to the arylene nucleus through a free valence of the ureido group, optionally together with other active ingredients such as thiabendazole, phenothiazine, piperazine, tetramisole, pyrantel, niclosamide or bunamidine. The arylene compound preferably has the formula I: where A is arylene, which may have substituents, T is ureido or thioureido, R 1 and R 2 are C 1-18 monovalent aliphatic or aromatic groups, Z is -NR 3 R 4 , where R 3 and R, are hydrogen or C 1-18 aliphatic, or an acylureido or acylthioureido group in which the acyl group has 1 to 18 carbon atoms.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25942372A | 1972-05-26 | 1972-05-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1389525A true GB1389525A (en) | 1975-04-03 |
Family
ID=22984886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2615073A Expired GB1389525A (en) | 1972-05-26 | 1973-06-01 | Anthelmintic phosphonoureido compounds |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS4948640A (en) |
| BR (1) | BR7303866D0 (en) |
| GB (1) | GB1389525A (en) |
| PH (1) | PH11784A (en) |
| ZA (1) | ZA733432B (en) |
-
1973
- 1973-05-22 ZA ZA733432A patent/ZA733432B/en unknown
- 1973-05-25 BR BR003866/73A patent/BR7303866D0/en unknown
- 1973-05-25 PH PH14654A patent/PH11784A/en unknown
- 1973-05-29 JP JP48060195A patent/JPS4948640A/ja active Pending
- 1973-06-01 GB GB2615073A patent/GB1389525A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| PH11784A (en) | 1978-07-05 |
| BR7303866D0 (en) | 1973-12-20 |
| ZA733432B (en) | 1974-06-26 |
| JPS4948640A (en) | 1974-05-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |