GB1389366A - Diagnostic agent - Google Patents

Diagnostic agent

Info

Publication number
GB1389366A
GB1389366A GB3842973A GB3842973A GB1389366A GB 1389366 A GB1389366 A GB 1389366A GB 3842973 A GB3842973 A GB 3842973A GB 3842973 A GB3842973 A GB 3842973A GB 1389366 A GB1389366 A GB 1389366A
Authority
GB
United Kingdom
Prior art keywords
diazonium
fluoborate
acid
paper
benzene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3842973A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of GB1389366A publication Critical patent/GB1389366A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/728—Bilirubin; including biliverdin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/903—Diazo reactions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N
    • Y10T436/146666—Bile pigment

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

Abstract

1389366 Bilirubin test paper BOEHRINGER MANNHEIM GmbH 14 Aug 1973 [17 Aug 1972] 38429/73 Heading G1B A "test paper" for the detection of bilirubin in body fluids contains (a) a diazonium salt capable of coupling with bilirubin in the presence of an acid, (b) sufficient acid and (c) a phosphate of formula: wherein R 1 and R 2 are organic groups. The "paper' may be filter paper, glass fibre paper or synthetic fibre fabric or fleece. The diazonium salt may be 2,6-dichloro-benzene diazonium fluoborate, 4- nitro-benzene-diazonium fluoborate, 3-nitrobenzene-diazonium-naphthalene-2-sulphonate, 2-chlorobenzene-diazonium-naphthalene-1,5- disulphonate, 4-fluorobenzene-diazonium-fluoborate, 2,5-dichlorobenzene-diazonium-fluoborate, 2,4-dibromobenzene-diazonium-fluoborate, 2,4,6- trichlorobenzene-diazonium fluoborate, 4-carboxy benzene-diazonium-p-toluene-sulphonate, diazosulphanilic acid, benzedine-bis-diazonium fluoborate, 4-(5-methyl-benzthiazolyl-2)-benzene -diazonium fluoborate and 2-chloro-benzenediazonium fluoborate. The acid may be meta; phosphoric acid, oxalic acid, citric acid or potassium bisulphate. The phosphate is usually one in which R 1 =R 2 . Organic groups specified for R include phenyl, o-tolyl, p-tolyl, 3,5-xylyl-, o-chlorophenyl, p-chlorophenyl, p-nitrophenyl, benzyl, cyclohexyl, pentyl, methyl, ethyl, 2-chloroethyl, 2-butoxyethyl, n-propyl, isopropyl, n-butyl, 2-ethylhexyl, isooctyl, isononyl, isodecyl, dodecyl, isotridecyl. The di-ester may be accompanied by the corresponding mono-ester. The paper may also include a stabilizer, e.g. sodium fluoborate, magnesium sulphate, sodium metaphosphate or an aryl sulphonate, and a wetting agent, e.g. sodium dodecylbenzene sulphonate. The reagents may be applied from solution in water, aqueous methanol, ethyl acetate or chloroform. The paper may be used for urine-testing.
GB3842973A 1972-08-17 1973-08-14 Diagnostic agent Expired GB1389366A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2240357A DE2240357C2 (en) 1972-08-17 1972-08-17 Test paper for the detection of bilirubin in body fluids

Publications (1)

Publication Number Publication Date
GB1389366A true GB1389366A (en) 1975-04-03

Family

ID=5853744

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3842973A Expired GB1389366A (en) 1972-08-17 1973-08-14 Diagnostic agent

Country Status (10)

Country Link
US (1) US3853476A (en)
JP (1) JPS5328119B2 (en)
AT (1) AT327399B (en)
BE (1) BE863862Q (en)
CH (1) CH572212A5 (en)
DE (1) DE2240357C2 (en)
FR (1) FR2199888A5 (en)
GB (1) GB1389366A (en)
HK (1) HK16278A (en)
KE (1) KE2829A (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3980696A (en) * 1974-07-25 1976-09-14 Beckman Instruments, Inc. Photodosimeter film badge
US3915649A (en) * 1974-08-14 1975-10-28 American Cyanamid Co Bilirubin test material
US4069017A (en) * 1977-01-14 1978-01-17 Eastman Kodak Company Colorimetric assay for bilirubin
US4115064A (en) * 1977-02-07 1978-09-19 Pierce Chemical Company Method for bilirubin determination
DE2728236B2 (en) * 1977-06-23 1980-09-18 Wolfgang Dr. 3300 Braunschweig Hirsch Stabilized diagnostic preparation for the detection of urobilinogen
US4246133A (en) * 1979-06-22 1981-01-20 Sherwood Medical Industries Inc. Stabilized diazotized sulfanilic acid solutions
DE3021305A1 (en) * 1980-06-06 1981-12-17 Behringwerke Ag, 3550 Marburg TESTING MEANS FOR DETECTING COUPLING CONNECTIONS
JP2555276B2 (en) * 1994-09-07 1996-11-20 古河電気工業株式会社 Flat optical fiber unit
US5955374A (en) * 1994-11-23 1999-09-21 Smith; Jack V. Method of detection of bilirubin in urine on an automated analyzer
US8012761B2 (en) 2006-12-14 2011-09-06 Kimberly-Clark Worldwide, Inc. Detection of formaldehyde in urine samples
US7846383B2 (en) 2006-12-15 2010-12-07 Kimberly-Clark Worldwide, Inc. Lateral flow assay device and absorbent article containing same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2854317A (en) * 1950-08-08 1958-09-30 Miles Lab Method and composition for testing bilirubin in urine
US3511607A (en) * 1967-10-06 1970-05-12 Smithkline Corp Laboratory reagent for assay of total bilirubin
US3585001A (en) * 1969-02-17 1971-06-15 Miles Lab Stabilized test device and process for detecting couplable compounds
US3585004A (en) * 1969-03-21 1971-06-15 Miles Lab Test composition and device for detecting couplable compounds
US3652222A (en) * 1969-04-07 1972-03-28 American Monitor Corp Bilirubin assay
AT316761B (en) * 1971-03-05 1974-07-25 Boehringer Mannheim Gmbh Reagent for the determination of total bilirubin

Also Published As

Publication number Publication date
CH572212A5 (en) 1976-01-30
HK16278A (en) 1978-03-31
AT327399B (en) 1976-01-26
US3853476A (en) 1974-12-10
KE2829A (en) 1978-04-07
FR2199888A5 (en) 1974-04-12
JPS5328119B2 (en) 1978-08-12
DE2240357B1 (en) 1974-02-14
JPS4965887A (en) 1974-06-26
DE2240357A1 (en) 1974-02-14
BE863862Q (en) 1978-08-10
ATA715373A (en) 1975-04-15
DE2240357C2 (en) 1974-09-12

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PE20 Patent expired after termination of 20 years

Effective date: 19930813