GB1383465A - Glucosamide of 1- p-chlorobenzoyl indolyl-3-acetic acid and processes for its preparation - Google Patents
Glucosamide of 1- p-chlorobenzoyl indolyl-3-acetic acid and processes for its preparationInfo
- Publication number
- GB1383465A GB1383465A GB2127873A GB2127873A GB1383465A GB 1383465 A GB1383465 A GB 1383465A GB 2127873 A GB2127873 A GB 2127873A GB 2127873 A GB2127873 A GB 2127873A GB 1383465 A GB1383465 A GB 1383465A
- Authority
- GB
- United Kingdom
- Prior art keywords
- chlorobenzoyl
- glucosamine
- reacting
- formula
- indolyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical group N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 abstract 5
- 125000000242 4-chlorobenzoyl group Chemical group ClC1=CC=C(C(=O)*)C=C1 0.000 abstract 3
- -1 1-(p-chlorobenzoyl) - 2 - methyl - 5 - methoxy indolyl Chemical group 0.000 abstract 2
- JLJZRAUDCHWQPS-FFLVSVRWSA-N 4-oxo-n-[(3r,4r,5s,6r)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]pentanamide Chemical compound CC(=O)CCC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O JLJZRAUDCHWQPS-FFLVSVRWSA-N 0.000 abstract 2
- JOOXCMJARBKPKM-UHFFFAOYSA-N 4-oxopentanoic acid Chemical compound CC(=O)CCC(O)=O JOOXCMJARBKPKM-UHFFFAOYSA-N 0.000 abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- 125000006283 4-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])* 0.000 abstract 1
- 239000012346 acetyl chloride Substances 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229960002442 glucosamine Drugs 0.000 abstract 1
- SEOVTRFCIGRIMH-UHFFFAOYSA-N indole-3-acetic acid Chemical compound C1=CC=C2C(CC(=O)O)=CNC2=C1 SEOVTRFCIGRIMH-UHFFFAOYSA-N 0.000 abstract 1
- 229940040102 levulinic acid Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 229940124531 pharmaceutical excipient Drugs 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Indole Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2411872 | 1972-05-09 | ||
| IT2039173A IT1063604B (it) | 1973-02-14 | 1973-02-14 | Procedimento per la preparazione della d(+)glucosamide dell acido 1-(p-clorobenzoil)-2-metil-5-metossi-indolil-3-acetico |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1383465A true GB1383465A (en) | 1974-02-12 |
Family
ID=26327513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2127873A Expired GB1383465A (en) | 1972-05-09 | 1973-05-04 | Glucosamide of 1- p-chlorobenzoyl indolyl-3-acetic acid and processes for its preparation |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS613800B2 (enrdf_load_stackoverflow) |
| AR (1) | AR198471A1 (enrdf_load_stackoverflow) |
| CA (1) | CA980767A (enrdf_load_stackoverflow) |
| CH (1) | CH606072A5 (enrdf_load_stackoverflow) |
| ES (1) | ES414509A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2184033B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1383465A (enrdf_load_stackoverflow) |
| NL (1) | NL179136C (enrdf_load_stackoverflow) |
| YU (1) | YU35267B (enrdf_load_stackoverflow) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1742534A4 (en) * | 2004-04-07 | 2011-04-13 | Univ Georgia | EXTERNAL GLUCOSAMINE AND GLUCOSAMINE / INFLAMMATORY PRODRUGS, COMPOSITIONS AND METHODS |
| US8034796B2 (en) | 2004-04-07 | 2011-10-11 | The University Of Georgia Research Foundation, Inc. | Glucosamine and glucosamine/anti-inflammatory mutual prodrugs, compositions, and methods |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3285908A (en) * | 1963-04-30 | 1966-11-15 | Merck & Co Inc | Indolyl acid amides |
-
1973
- 1973-05-04 GB GB2127873A patent/GB1383465A/en not_active Expired
- 1973-05-08 ES ES414509A patent/ES414509A1/es not_active Expired
- 1973-05-08 CH CH651173A patent/CH606072A5/xx not_active IP Right Cessation
- 1973-05-09 YU YU1222/73A patent/YU35267B/xx unknown
- 1973-05-09 JP JP48050816A patent/JPS613800B2/ja not_active Expired
- 1973-05-09 CA CA170,835A patent/CA980767A/en not_active Expired
- 1973-05-09 FR FR7316793A patent/FR2184033B1/fr not_active Expired
- 1973-05-09 NL NLAANVRAGE7306501,A patent/NL179136C/xx not_active IP Right Cessation
-
1974
- 1974-04-08 AR AR253199A patent/AR198471A1/es active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1742534A4 (en) * | 2004-04-07 | 2011-04-13 | Univ Georgia | EXTERNAL GLUCOSAMINE AND GLUCOSAMINE / INFLAMMATORY PRODRUGS, COMPOSITIONS AND METHODS |
| US8034796B2 (en) | 2004-04-07 | 2011-10-11 | The University Of Georgia Research Foundation, Inc. | Glucosamine and glucosamine/anti-inflammatory mutual prodrugs, compositions, and methods |
| US8361990B2 (en) | 2004-04-07 | 2013-01-29 | University Of Georgia Research Foundation, Inc. | Glucosamine and glucosamine/anti-inflammatory mutual prodrugs, compositions, and methods |
Also Published As
| Publication number | Publication date |
|---|---|
| CA980767A (en) | 1975-12-30 |
| AR198471A1 (es) | 1974-06-21 |
| YU122273A (en) | 1980-04-30 |
| JPS613800B2 (enrdf_load_stackoverflow) | 1986-02-04 |
| NL179136B (nl) | 1986-02-17 |
| CH606072A5 (enrdf_load_stackoverflow) | 1978-10-13 |
| AU5506473A (en) | 1974-11-07 |
| YU35267B (en) | 1980-10-31 |
| NL179136C (nl) | 1986-07-16 |
| FR2184033B1 (enrdf_load_stackoverflow) | 1976-09-03 |
| FR2184033A1 (enrdf_load_stackoverflow) | 1973-12-21 |
| JPS4966814A (enrdf_load_stackoverflow) | 1974-06-28 |
| NL7306501A (enrdf_load_stackoverflow) | 1973-11-13 |
| ES414509A1 (es) | 1976-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |