GB1381464A - Pyrimidine derivatives - Google Patents
Pyrimidine derivativesInfo
- Publication number
- GB1381464A GB1381464A GB565373A GB565373A GB1381464A GB 1381464 A GB1381464 A GB 1381464A GB 565373 A GB565373 A GB 565373A GB 565373 A GB565373 A GB 565373A GB 1381464 A GB1381464 A GB 1381464A
- Authority
- GB
- United Kingdom
- Prior art keywords
- difluoroethyl
- pentafluoroethyl
- trifluoroethyl
- feb
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Feed For Specific Animals (AREA)
- Fodder In General (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
1381464 Pyrimidine derivatives MERCK & CO Inc 5 Feb 1973 [8 Feb 1972] 5653/73 Heading C2C [Also in Division A5] Novel coccidiostatic compounds (I) where R<SP>1</SP> is C 1 to C 3 alkyl, methoxymethyl, cyclopropylmethyl, C 1 to C 3 perfluoroalkyl, 1,1- difluoroethyl or 2,2,2-trifluoroethyl and -#N<SP>)</SP> signifies a radical (II) to (VIII) or a derivative thereof having a single additional Me group in a position not occupied by R, R, R* or R<SP>11</SP> (R and R<SP>11</SP> are H or Me and one of R and R* is H and the other is Me), are made, e.g. by quaternization. The following compounds are prepared: 2- pentafluoroethyl-, -heptafluoropropyl-, -trifluoromethyl-, -(2,2,2 - trifluoroethyl)- and -(1,1 - difluoroethyl) - 4 - amino - 5 - hydroxymethyl - pyrimidines, 2 - pentafluoroethyl - 4- amino - 5 - bromomethyl pyrimidine hydrobromide pentafluoropropionamidine, 3,3,3-trifluoro - propionamidine and its hydrochloride, 3,3,3 - trifluoropropionimido ethyl ester hydrochloride, ethyl 2,2-difluoropropionate, 2,2-difluoropropionamide, 2,2 - difluoropropionitrile and 2,2-difluoropropionamidine.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22462072A | 1972-02-08 | 1972-02-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1381464A true GB1381464A (en) | 1975-01-22 |
Family
ID=22841447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB565373A Expired GB1381464A (en) | 1972-02-08 | 1973-02-05 | Pyrimidine derivatives |
Country Status (18)
| Country | Link |
|---|---|
| JP (1) | JPS5829059B2 (en) |
| AR (1) | AR205081A1 (en) |
| AT (1) | AT327913B (en) |
| AU (1) | AU472130B2 (en) |
| BE (1) | BE795071A (en) |
| BG (1) | BG20796A3 (en) |
| CA (1) | CA985684A (en) |
| DD (1) | DD104301A5 (en) |
| ES (1) | ES411392A1 (en) |
| FR (1) | FR2181712B1 (en) |
| GB (1) | GB1381464A (en) |
| HU (1) | HU165410B (en) |
| IE (1) | IE37178B1 (en) |
| IL (1) | IL41447A0 (en) |
| LU (1) | LU66983A1 (en) |
| NL (1) | NL7301317A (en) |
| RO (1) | RO71884A (en) |
| ZA (1) | ZA73874B (en) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE597062A (en) * | 1959-11-20 | |||
| NL109464C (en) * | 1960-02-02 | |||
| IL26554A (en) * | 1965-10-05 | 1971-04-28 | Ciba Geigy Ag | Compositions containing pyrimidine derivatives for treatment of coccidiosis |
-
0
- BE BE795071D patent/BE795071A/en unknown
-
1973
- 1973-01-01 AR AR246419A patent/AR205081A1/en active
- 1973-01-30 NL NL7301317A patent/NL7301317A/xx not_active Application Discontinuation
- 1973-01-31 CA CA162,520A patent/CA985684A/en not_active Expired
- 1973-02-01 RO RO7373694A patent/RO71884A/en unknown
- 1973-02-02 IE IE169/73A patent/IE37178B1/en unknown
- 1973-02-02 AU AU51759/73A patent/AU472130B2/en not_active Expired
- 1973-02-02 IL IL41447A patent/IL41447A0/en unknown
- 1973-02-05 BG BG22620A patent/BG20796A3/xx unknown
- 1973-02-05 GB GB565373A patent/GB1381464A/en not_active Expired
- 1973-02-06 DD DD168691A patent/DD104301A5/xx unknown
- 1973-02-07 ES ES411392A patent/ES411392A1/en not_active Expired
- 1973-02-07 AT AT108473A patent/AT327913B/en not_active IP Right Cessation
- 1973-02-07 HU HUME1602A patent/HU165410B/hu unknown
- 1973-02-07 ZA ZA730874A patent/ZA73874B/en unknown
- 1973-02-07 LU LU66983A patent/LU66983A1/xx unknown
- 1973-02-08 JP JP48015257A patent/JPS5829059B2/en not_active Expired
- 1973-02-08 FR FR7304436A patent/FR2181712B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5829059B2 (en) | 1983-06-20 |
| ATA108473A (en) | 1975-05-15 |
| AT327913B (en) | 1976-02-25 |
| JPS4887010A (en) | 1973-11-16 |
| NL7301317A (en) | 1973-08-10 |
| FR2181712B1 (en) | 1976-03-05 |
| IL41447A0 (en) | 1973-04-30 |
| DE2306001B2 (en) | 1977-03-17 |
| IE37178B1 (en) | 1977-05-25 |
| LU66983A1 (en) | 1973-08-17 |
| RO71884A (en) | 1982-05-10 |
| ES411392A1 (en) | 1976-05-16 |
| BE795071A (en) | 1973-08-07 |
| DE2306001A1 (en) | 1973-08-23 |
| HU165410B (en) | 1974-08-28 |
| AU472130B2 (en) | 1976-05-20 |
| AU5175973A (en) | 1974-08-08 |
| FR2181712A1 (en) | 1973-12-07 |
| CA985684A (en) | 1976-03-16 |
| AR205081A1 (en) | 1976-04-05 |
| ZA73874B (en) | 1974-09-25 |
| DD104301A5 (en) | 1974-03-05 |
| BG20796A3 (en) | 1975-12-20 |
| IE37178L (en) | 1973-08-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |