GB1379940A - Carbazole derivatives - Google Patents
Carbazole derivativesInfo
- Publication number
- GB1379940A GB1379940A GB6003972A GB6003972A GB1379940A GB 1379940 A GB1379940 A GB 1379940A GB 6003972 A GB6003972 A GB 6003972A GB 6003972 A GB6003972 A GB 6003972A GB 1379940 A GB1379940 A GB 1379940A
- Authority
- GB
- United Kingdom
- Prior art keywords
- general formula
- group
- hydrogen atom
- acid addition
- addition salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000000609 carbazolyl group Chemical class C1(=CC=CC=2C3=CC=CC=C3NC12)* 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 10
- 239000002253 acid Substances 0.000 abstract 9
- 150000003839 salts Chemical class 0.000 abstract 9
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 8
- -1 cyano, hydroxy Chemical group 0.000 abstract 6
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 abstract 5
- 150000001412 amines Chemical class 0.000 abstract 4
- 229910021529 ammonia Inorganic materials 0.000 abstract 4
- 125000006239 protecting group Chemical group 0.000 abstract 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- 150000001408 amides Chemical class 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- UHZYTMXLRWXGPK-UHFFFAOYSA-N phosphorus pentachloride Chemical compound ClP(Cl)(Cl)(Cl)Cl UHZYTMXLRWXGPK-UHFFFAOYSA-N 0.000 abstract 2
- XKLNOVWDVMWTOB-UHFFFAOYSA-N 2,3,4,9-tetrahydro-1h-carbazole Chemical compound N1C2=CC=CC=C2C2=C1CCCC2 XKLNOVWDVMWTOB-UHFFFAOYSA-N 0.000 abstract 1
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 abstract 1
- YOETUEMZNOLGDB-UHFFFAOYSA-N 2-methylpropyl carbonochloridate Chemical compound CC(C)COC(Cl)=O YOETUEMZNOLGDB-UHFFFAOYSA-N 0.000 abstract 1
- YYROPELSRYBVMQ-UHFFFAOYSA-N 4-toluenesulfonyl chloride Chemical compound CC1=CC=C(S(Cl)(=O)=O)C=C1 YYROPELSRYBVMQ-UHFFFAOYSA-N 0.000 abstract 1
- 101000653791 Bos taurus Protein S100-A12 Proteins 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- JCETXQVQDRTCBM-UHFFFAOYSA-N Cl.C(C1=CC=CC=C1)OC=1C=C2C=3CCCC(C3NC2=CC1)CN(C)C Chemical compound Cl.C(C1=CC=CC=C1)OC=1C=C2C=3CCCC(C3NC2=CC1)CN(C)C JCETXQVQDRTCBM-UHFFFAOYSA-N 0.000 abstract 1
- 239000002841 Lewis acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000002152 alkylating effect Effects 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 230000036528 appetite Effects 0.000 abstract 1
- 235000019789 appetite Nutrition 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 150000001540 azides Chemical class 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- KXZJHVJKXJLBKO-UHFFFAOYSA-N chembl1408157 Chemical compound N=1C2=CC=CC=C2C(C(=O)O)=CC=1C1=CC=C(O)C=C1 KXZJHVJKXJLBKO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- 239000012280 lithium aluminium hydride Substances 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- HKOOXMFOFWEVGF-UHFFFAOYSA-N phenylhydrazine Chemical compound NNC1=CC=CC=C1 HKOOXMFOFWEVGF-UHFFFAOYSA-N 0.000 abstract 1
- 229940067157 phenylhydrazine Drugs 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1923771 | 1971-12-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1379940A true GB1379940A (en) | 1975-01-08 |
Family
ID=4438197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB6003972A Expired GB1379940A (en) | 1971-12-30 | 1972-12-29 | Carbazole derivatives |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US3859304A (cg-RX-API-DMAC7.html) |
| JP (1) | JPS4876865A (cg-RX-API-DMAC7.html) |
| AU (1) | AU4923672A (cg-RX-API-DMAC7.html) |
| BE (1) | BE793493A (cg-RX-API-DMAC7.html) |
| DE (1) | DE2263682A1 (cg-RX-API-DMAC7.html) |
| FR (1) | FR2166140B1 (cg-RX-API-DMAC7.html) |
| GB (1) | GB1379940A (cg-RX-API-DMAC7.html) |
| IL (1) | IL40931A0 (cg-RX-API-DMAC7.html) |
| NL (1) | NL7217534A (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA728242B (cg-RX-API-DMAC7.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2275202A1 (fr) * | 1974-06-18 | 1976-01-16 | Ayerst Mckenna & Harrison | Derives tricycliques d'alcoylamines et preparation de ceux-ci |
| US4319029A (en) * | 1979-08-06 | 1982-03-09 | American Home Products Corporation | Hydroxyalkanamide tetrahydrocarbazoles |
| US4235903A (en) * | 1979-08-06 | 1980-11-25 | American Home Products Corporation | 1-Hydroxyalkanamine tetrahydrocarbazoles and cyclopent[b]indoles, compositions and method of use |
| EP0307077A1 (en) * | 1987-07-21 | 1989-03-15 | Merck Frosst Canada Inc. | Tetrahydrocarbazoles for the improvement of cyclosporin therapy |
| US5350762A (en) * | 1993-03-08 | 1994-09-27 | Hoechst-Roussel Pharmaceuticals Incorporated | Tetrahydrocyclopent[B]indole methanamines and related compounds |
| US20060074124A1 (en) * | 2003-09-12 | 2006-04-06 | Andrew Napper | Methods of treating a disorder |
| WO2005026112A2 (en) * | 2003-09-12 | 2005-03-24 | Elixir Pharmaceuticals, Inc. | Methods of treating a disorder |
| WO2006058088A2 (en) * | 2004-11-23 | 2006-06-01 | Ptc Therapeutics, Inc. | Carbazole, carboline and indole derivatives useful in the inhibition of vegf production |
| EP1865913A1 (en) * | 2005-03-11 | 2007-12-19 | Elixir Pharmaceuticals, Inc. | Sirt inhibitors that bind to nad |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3634420A (en) * | 1969-05-09 | 1972-01-11 | American Cyanamid Co | 3(morpholinomethyl)-2 3-dihydro-carbazol-4(1h)-ones |
| GB1260768A (en) * | 1969-08-28 | 1972-01-19 | Pfizer | N-alkyl-tetrahydrocarbazoles |
| US3769298A (en) * | 1971-04-02 | 1973-10-30 | Pfizer | Substituted aminomethylcarbazoles |
-
0
- BE BE793493D patent/BE793493A/xx unknown
-
1972
- 1972-11-21 ZA ZA728242A patent/ZA728242B/xx unknown
- 1972-11-23 AU AU49236/72A patent/AU4923672A/en not_active Expired
- 1972-11-27 IL IL40931A patent/IL40931A0/xx unknown
- 1972-12-21 US US317499A patent/US3859304A/en not_active Expired - Lifetime
- 1972-12-22 NL NL7217534A patent/NL7217534A/xx unknown
- 1972-12-27 DE DE2263682A patent/DE2263682A1/de active Pending
- 1972-12-27 JP JP47130102A patent/JPS4876865A/ja active Pending
- 1972-12-28 FR FR7246666A patent/FR2166140B1/fr not_active Expired
- 1972-12-29 GB GB6003972A patent/GB1379940A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2166140A1 (cg-RX-API-DMAC7.html) | 1973-08-10 |
| FR2166140B1 (cg-RX-API-DMAC7.html) | 1976-07-02 |
| AU4923672A (en) | 1974-05-23 |
| DE2263682A1 (de) | 1973-07-05 |
| BE793493A (fr) | 1973-06-29 |
| ZA728242B (en) | 1973-08-29 |
| IL40931A0 (en) | 1973-01-30 |
| JPS4876865A (cg-RX-API-DMAC7.html) | 1973-10-16 |
| US3859304A (en) | 1975-01-07 |
| NL7217534A (cg-RX-API-DMAC7.html) | 1973-07-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CSNS | Application of which complete specification have been accepted and published, but patent is not sealed |