GB1378481A - Preparation of substituted ureas - Google Patents

Preparation of substituted ureas

Info

Publication number
GB1378481A
GB1378481A GB3127372*[A GB3127372A GB1378481A GB 1378481 A GB1378481 A GB 1378481A GB 3127372 A GB3127372 A GB 3127372A GB 1378481 A GB1378481 A GB 1378481A
Authority
GB
United Kingdom
Prior art keywords
substituted
thiolcarbamate
disubstituted
unsubstituted
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3127372*[A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quimco GmbH
Original Assignee
Quimco GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quimco GmbH filed Critical Quimco GmbH
Priority to GB3127372*[A priority Critical patent/GB1378481A/en
Priority to DE2258473A priority patent/DE2258473C3/en
Priority to IL7240996A priority patent/IL40996A0/en
Priority to JP47122374A priority patent/JPS5249460B2/ja
Priority to DD167330A priority patent/DD100939A5/xx
Publication of GB1378481A publication Critical patent/GB1378481A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

1378481 Substituted ureas QUIMCO GmbH 4 Dec 1972 [6 Dec 1971 4 July 1972] 56582/71 and 31273/72 Heading C2C A process for preparing substituted ureas of the general formula:- R(NHCONR<SP>1</SP>R<SP>11</SP>) n in which R is an unsubstituted or substituted aliphatic, cycloaliphatic or heterocyclic radical and n is an integer or in which R is a hydrogen atom and n is 1, and R<SP>1</SP> and R<SP>11</SP>, which may be the same or different, are unsubstituted or substituted monovalent aliphatic radicals or together represent an unsubstituted or substituted divalent radical in which at least one of the two carbon atoms adjoining the nitrogen atom of the urea is aliphatic, comprises reacting a compound of the general formula:-R(NH 2 ) n at a temperature of from 50 to 200‹ C. with a secondary ammonium N,N-disubstituted thiolcarbamate of the general formula: -R<SP>1</SP>R<SP>11</SP>NCO<SP>##</SP>S.NH 2 R<SP>1</SP>R<SP>11</SP>. The reaction may be carried out at atmospheric or superatmospheric pressure, and in the presence of an inert solvent. The reaction may also be carried out in two stages, where the major product of the first stage carried out below 50‹ C. which is a primary ammonium N,N-disubstituted thiolcarbamate or ammonium N,N-disubstituted thiolcarbamate of formula:-(R<SP>1</SP>R<SP>11</SP>NCOS<SP>##</SP>.NH 3 ) n R is then thermally decomposed at 50 to 200‹ C.
GB3127372*[A 1971-12-06 1972-07-04 Preparation of substituted ureas Expired GB1378481A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
GB3127372*[A GB1378481A (en) 1971-12-06 1972-07-04 Preparation of substituted ureas
DE2258473A DE2258473C3 (en) 1971-12-06 1972-11-29 Process for the preparation of aliphatic, cycloaliphatic and / or heterocyclic trisubstituted or N, N-disubstituted ureas
IL7240996A IL40996A0 (en) 1971-12-06 1972-12-05 The preparation of substituted ureas
JP47122374A JPS5249460B2 (en) 1971-12-06 1972-12-06
DD167330A DD100939A5 (en) 1971-12-06 1972-12-06

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB5658271 1971-12-06
GB3127372*[A GB1378481A (en) 1971-12-06 1972-07-04 Preparation of substituted ureas

Publications (1)

Publication Number Publication Date
GB1378481A true GB1378481A (en) 1974-12-27

Family

ID=26260819

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3127372*[A Expired GB1378481A (en) 1971-12-06 1972-07-04 Preparation of substituted ureas

Country Status (5)

Country Link
JP (1) JPS5249460B2 (en)
DD (1) DD100939A5 (en)
DE (1) DE2258473C3 (en)
GB (1) GB1378481A (en)
IL (1) IL40996A0 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4115445A (en) * 1972-04-05 1978-09-19 Quimco Gmbh Process for the preparation of trisubstituted ureas

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5829758A (en) * 1981-07-31 1983-02-22 キムコ・ゲ−エムベ−ハ− Manufacture of substituted ureas
DE19749979C2 (en) * 1997-11-05 2000-01-13 Schering Ag Medicaments containing N, N'-substituted ureas and their derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4115445A (en) * 1972-04-05 1978-09-19 Quimco Gmbh Process for the preparation of trisubstituted ureas

Also Published As

Publication number Publication date
DE2258473B2 (en) 1979-06-21
JPS4864026A (en) 1973-09-05
IL40996A0 (en) 1973-02-28
DE2258473A1 (en) 1973-06-14
DE2258473C3 (en) 1982-12-23
DD100939A5 (en) 1973-10-12
JPS5249460B2 (en) 1977-12-17

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee