GB1377343A - 1-cyclopropyl-1-phenyl-omega-amino-1-alkanols and 1-lower alkylacyl derivatives - Google Patents

1-cyclopropyl-1-phenyl-omega-amino-1-alkanols and 1-lower alkylacyl derivatives

Info

Publication number
GB1377343A
GB1377343A GB318973A GB318973A GB1377343A GB 1377343 A GB1377343 A GB 1377343A GB 318973 A GB318973 A GB 318973A GB 318973 A GB318973 A GB 318973A GB 1377343 A GB1377343 A GB 1377343A
Authority
GB
United Kingdom
Prior art keywords
cyclopropyl
phenyl
amino
alkanols
omega
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB318973A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AH Robins Co Inc
Original Assignee
AH Robins Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AH Robins Co Inc filed Critical AH Robins Co Inc
Publication of GB1377343A publication Critical patent/GB1377343A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1377343 Basic alcohols and esters A H ROBINS CO Inc 22 Jan 1973 [28 Jan 1972] 3189/73 Heading C2C Compounds of the general formula (Am = C 1-8 alkylamino, di(C 1-8 alkyl)amino, piperidino; R=H, C 2-9 alkanoyl; R<SP>1</SP> = H, halogen, CF 3 , C 1-8 alkyl or alkoxy; n = 2, 3) and their acid addition salts, are prepared by (a) reacting a 1-cyclopropyl-3-amio-1-propanone with a phenyl Grignard and/or phenl lithium or reacting cyclopropyl phenyl ketone with a 3- aminopropylmagnesium halide, followed in either case by hydrolysis, or (b) hydrolysing an N-acyl derivative, optionally followed by O- acylation and/or salt formation. The preparation of 1-cyclopropyl-3-(N-methylacetamido) - 1 - (m - trifluoromethylphenyl)- 1 propanol is described. The alcohols are antidepressants and the esters are analgesics; they may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
GB318973A 1972-01-28 1973-01-22 1-cyclopropyl-1-phenyl-omega-amino-1-alkanols and 1-lower alkylacyl derivatives Expired GB1377343A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22180472A 1972-01-28 1972-01-28

Publications (1)

Publication Number Publication Date
GB1377343A true GB1377343A (en) 1974-12-11

Family

ID=22829458

Family Applications (1)

Application Number Title Priority Date Filing Date
GB318973A Expired GB1377343A (en) 1972-01-28 1973-01-22 1-cyclopropyl-1-phenyl-omega-amino-1-alkanols and 1-lower alkylacyl derivatives

Country Status (11)

Country Link
JP (2) JPS5755708B2 (en)
AU (1) AU471111B2 (en)
CA (1) CA978192A (en)
CH (1) CH563336A5 (en)
DE (1) DE2303822C2 (en)
DK (1) DK135941C (en)
ES (1) ES411037A1 (en)
FR (1) FR2181695B1 (en)
GB (1) GB1377343A (en)
PH (1) PH10711A (en)
ZA (1) ZA73519B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH623301A5 (en) * 1975-06-19 1981-05-29 Mitsubishi Chem Ind Process for the preparation of ortho-substituted phenoxyalkylamino compounds
CA1086733A (en) * 1976-12-06 1980-09-30 Ryoji Kikumoto Pharmaceutically active 2-substituted-1-(omega- aminoalkoxy) benzenes
JPS614643U (en) * 1984-06-16 1986-01-11 株式会社 日本メデイカル・サプライ urethral catheter
JPH0277048U (en) * 1988-11-18 1990-06-13

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE950550C (en) * 1953-01-31 1956-10-11 Basf Ag Process for the preparation of basic substituted phenylcycloalkenylpropanols

Also Published As

Publication number Publication date
ZA73519B (en) 1973-10-31
DK135941B (en) 1977-07-18
PH10711A (en) 1977-08-24
JPS5755708B2 (en) 1982-11-25
JPS5857419B2 (en) 1983-12-20
JPS4881843A (en) 1973-11-01
CH563336A5 (en) 1975-06-30
DK135941C (en) 1978-01-30
FR2181695B1 (en) 1976-05-14
AU471111B2 (en) 1976-04-08
FR2181695A1 (en) 1973-12-07
DE2303822C2 (en) 1984-07-12
ES411037A1 (en) 1976-03-01
DE2303822A1 (en) 1973-08-02
JPS5821651A (en) 1983-02-08
CA978192A (en) 1975-11-18
AU5158773A (en) 1974-08-01

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee