GB1368731A - 9alpha 11alpha-epoxy spirolactones and corresponding spirolactols and lactol ethers - Google Patents
9alpha 11alpha-epoxy spirolactones and corresponding spirolactols and lactol ethersInfo
- Publication number
- GB1368731A GB1368731A GB257473A GB257473A GB1368731A GB 1368731 A GB1368731 A GB 1368731A GB 257473 A GB257473 A GB 257473A GB 257473 A GB257473 A GB 257473A GB 1368731 A GB1368731 A GB 1368731A
- Authority
- GB
- United Kingdom
- Prior art keywords
- epoxy
- choh
- give
- spirolactones
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
1368731 9,11-Epoxy-spirolactones and related steroids G D SEARLE & CO 18 Jan 1973 [24 Jan 1972] 2574/73 Heading C2U Novel steroids of the formulae wherein Z is CO or CHOH or CHO (C 1-7 alkyl) in either configuration and X is H, ammonium or one equivalent of an alkali or alkaline earth metal are prepared from 9α,11α-epoxy-4<SP>1</SP>,5<SP>1</SP>-dihydrospiro[androst - 4 - ene - 17,21 - (3<SP>1</SP>H)- furan]-3,5<SP>1</SP>-dione by (a) catalytic hydrogenation to give the 5#-compound (Ia) wherein Z is CO, and when desired conversion of this to the 3,3- dimethyl ketal and reduction and hydrolysis of this with lithium and ammonia to give the 5#- compound (Ia) wherein Z is CHOH which may subsequently be etherified using an alkanol in the presence of acid; or (b) reduction of the same starting material with lithium and ammonia to give a mixture of the 5α-compounds (Ia) wherein Z is CO and CHOH, of which the latter may subsequently be etherified. Products wherein Z is CO may be converted to alkali metal salts (Ib) by reaction with alkali metal hydroxides and these salts may be converted to the free acids and other salts by standard procedures. The novel steroids are diuretic and hypotensive agents. Solutions in corn oil and other inert solvents, e.g. water, are referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22041172A | 1972-01-24 | 1972-01-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1368731A true GB1368731A (en) | 1974-10-02 |
Family
ID=22823437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB257473A Expired GB1368731A (en) | 1972-01-24 | 1973-01-18 | 9alpha 11alpha-epoxy spirolactones and corresponding spirolactols and lactol ethers |
Country Status (3)
| Country | Link |
|---|---|
| DE (1) | DE2303216A1 (en) |
| FR (1) | FR2181683B1 (en) |
| GB (1) | GB1368731A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4552871A (en) * | 1983-04-13 | 1985-11-12 | Ciba Geigy Corporation | Steroids of the 20-spiroxane series, processes for the manufacture thereof, pharmaceutical preparations containing such compounds and the use of the latter |
-
1973
- 1973-01-18 GB GB257473A patent/GB1368731A/en not_active Expired
- 1973-01-23 FR FR7302301A patent/FR2181683B1/fr not_active Expired
- 1973-01-24 DE DE19732303216 patent/DE2303216A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| FR2181683A1 (en) | 1973-12-07 |
| FR2181683B1 (en) | 1975-10-10 |
| DE2303216A1 (en) | 1973-08-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |