GB1362696A - Tri-peptide synthesis - Google Patents
Tri-peptide synthesisInfo
- Publication number
- GB1362696A GB1362696A GB3606371A GB3606371A GB1362696A GB 1362696 A GB1362696 A GB 1362696A GB 3606371 A GB3606371 A GB 3606371A GB 3606371 A GB3606371 A GB 3606371A GB 1362696 A GB1362696 A GB 1362696A
- Authority
- GB
- United Kingdom
- Prior art keywords
- molar equivalent
- amide
- solution
- mixture
- inert
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000010647 peptide synthesis reaction Methods 0.000 title 1
- 150000001408 amides Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- ZKGMBAZWQLUSMW-VKHMYHEASA-N (2,3,4,5,6-pentachlorophenyl) (2s)-5-oxopyrrolidine-2-carboxylate Chemical compound ClC1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1OC(=O)[C@H]1NC(=O)CC1 ZKGMBAZWQLUSMW-VKHMYHEASA-N 0.000 abstract 1
- CSKSDAVTCKIENY-WCCKRBBISA-N (2s)-pyrrolidine-2-carboxamide;hydrochloride Chemical compound Cl.NC(=O)[C@@H]1CCCN1 CSKSDAVTCKIENY-WCCKRBBISA-N 0.000 abstract 1
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 abstract 1
- 238000013019 agitation Methods 0.000 abstract 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 108700020496 deamido- thyrotropin-releasing hormone Proteins 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 238000006345 epimerization reaction Methods 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06173—Dipeptides with the first amino acid being heterocyclic and Glp-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0825—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Glp-amino acid; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6179070A | 1970-08-06 | 1970-08-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1362696A true GB1362696A (en) | 1974-08-07 |
Family
ID=22038158
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3606371A Expired GB1362696A (en) | 1970-08-06 | 1971-07-30 | Tri-peptide synthesis |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS4917264B1 (enExample) |
| AU (1) | AU449817B2 (enExample) |
| CA (1) | CA953710A (enExample) |
| DE (1) | DE2139310C3 (enExample) |
| FR (1) | FR2104025A5 (enExample) |
| GB (1) | GB1362696A (enExample) |
| SE (1) | SE375301B (enExample) |
-
1971
- 1971-07-08 CA CA117,749A patent/CA953710A/en not_active Expired
- 1971-07-13 AU AU31148/71A patent/AU449817B2/en not_active Expired
- 1971-07-30 GB GB3606371A patent/GB1362696A/en not_active Expired
- 1971-08-03 SE SE994771A patent/SE375301B/xx unknown
- 1971-08-05 JP JP46058753A patent/JPS4917264B1/ja active Pending
- 1971-08-05 DE DE19712139310 patent/DE2139310C3/de not_active Expired
- 1971-08-05 FR FR7128806A patent/FR2104025A5/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2139310B2 (de) | 1973-07-26 |
| CA953710A (en) | 1974-08-27 |
| DE2139310A1 (de) | 1972-02-10 |
| AU3114871A (en) | 1973-01-18 |
| JPS4917264B1 (enExample) | 1974-04-27 |
| FR2104025A5 (enExample) | 1972-04-14 |
| DE2139310C3 (de) | 1974-03-14 |
| AU449817B2 (en) | 1974-06-20 |
| SE375301B (enExample) | 1975-04-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |