GB1359278A - 2- -thioxanthenyl- -alkanoic acids their preparation and pharma ceutical compositions containing them - Google Patents

2- -thioxanthenyl- -alkanoic acids their preparation and pharma ceutical compositions containing them

Info

Publication number
GB1359278A
GB1359278A GB5760172A GB5760172A GB1359278A GB 1359278 A GB1359278 A GB 1359278A GB 5760172 A GB5760172 A GB 5760172A GB 5760172 A GB5760172 A GB 5760172A GB 1359278 A GB1359278 A GB 1359278A
Authority
GB
United Kingdom
Prior art keywords
propionic
prepared
acids
compounds
alkanoic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5760172A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Welfide Corp
Original Assignee
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Welfide Corp filed Critical Welfide Corp
Priority to GB5760172A priority Critical patent/GB1359278A/en
Publication of GB1359278A publication Critical patent/GB1359278A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/10—Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
    • C07D335/12—Thioxanthenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

1359278 2 - (Thioxanthanyl) - alkanoic acids YOSHITOMI PHARMACEUTICAL INDUSTRIES Ltd 12 Dec 1972 57601/72 Heading C2C Novel compounds I: in which X is hydrogen or halogen, R 1 and R 2 are hydrogen or C 1-4 alkyl and Y is S or SO 2 and their salts, are prepared by hydrolysing a functional derivative of the above acid (preferably the ester nitrile, amido, imino-ether or thio-carbonyl-morpholino). Compounds prepared are 2-(thioxanthen-2-yl)-acetic-, propionic-, butyric and iso-butyric acids; 2-(7-chlorothioxanthen-2-yl)-propionic acid; or 2-(thioxanthan- 2-yl)-propionic acid-10,10-dioxide. The ethyl ester of the 2-propionic acids of Formula I are prepared by reduction of a xanthone to a compound III which is acetylated, reduced to the alcohol and brominated to form compound VI which is reacted with potassium or cuprous cyanide in dimethylsulphoxide and the nitrile formed is hydrolysed with ethanol and hydrochloric acid. Compounds (I) are anti-inflammatory agents and analgesics and form with a carrier or diluent a pharmaceutical composition which may be administered orally or parenterally or topically.
GB5760172A 1972-12-12 1972-12-12 2- -thioxanthenyl- -alkanoic acids their preparation and pharma ceutical compositions containing them Expired GB1359278A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB5760172A GB1359278A (en) 1972-12-12 1972-12-12 2- -thioxanthenyl- -alkanoic acids their preparation and pharma ceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5760172A GB1359278A (en) 1972-12-12 1972-12-12 2- -thioxanthenyl- -alkanoic acids their preparation and pharma ceutical compositions containing them

Publications (1)

Publication Number Publication Date
GB1359278A true GB1359278A (en) 1974-07-10

Family

ID=10479569

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5760172A Expired GB1359278A (en) 1972-12-12 1972-12-12 2- -thioxanthenyl- -alkanoic acids their preparation and pharma ceutical compositions containing them

Country Status (1)

Country Link
GB (1) GB1359278A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0110831A1 (en) * 1982-11-25 1984-06-13 Ciba-Geigy Ag Thioxanthones substituted by alpha-aminoalkyl groups

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0110831A1 (en) * 1982-11-25 1984-06-13 Ciba-Geigy Ag Thioxanthones substituted by alpha-aminoalkyl groups

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Legal Events

Date Code Title Description
PS Patent sealed
434A Offer to surrender (sect. 34/1949)
434A Offer to surrender (sect. 34/1949)