GB1358114A - One step process for the production of a mono-ester of macrolide antibiotics - Google Patents

One step process for the production of a mono-ester of macrolide antibiotics

Info

Publication number
GB1358114A
GB1358114A GB3008372A GB3008372A GB1358114A GB 1358114 A GB1358114 A GB 1358114A GB 3008372 A GB3008372 A GB 3008372A GB 3008372 A GB3008372 A GB 3008372A GB 1358114 A GB1358114 A GB 1358114A
Authority
GB
United Kingdom
Prior art keywords
leucomycin
group
antibiotic
mono
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3008372A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Seika Kaisha Ltd
Original Assignee
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd
Publication of GB1358114A publication Critical patent/GB1358114A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

1358114 Esterifying antibiotic SF-837 and leucomycin A 3 MEIJI SEIKA KAISHA Ltd 27 June 1972 [29 June 1971] 30083/72 Heading C2A Monoesters of the antibiotics SF-837 substance and leucomycin A 3 having the general Formula (II) wherein R and R<SP>1</SP> are both methyl groups (SF-837 esters) or R is hydrogen and R<SP>1</SP> is an isopropyl group (leucomycin A 3 esters), and R<SP>11</SP> is a C 1 -C 4 alkyl group which may be substituted, a C 1 -C 4 alkenyl group, an aromatic group or a heterocyclic group, are prepared by reacting SF-837 or leucomycin A 3 with an acyl halide of formula R<SP>11</SP>COX wherein R<SP>11</SP> has the aforesaid meaning and X is Cl or Br, in solution in a reaction medium selected from benzene, toluene, ethyl acetate and methyl isobutylketone in the presence of pyridine or picoline as an acidbinding agent. Pharmaceutical compositions having antibiotic activity comprise a mono-ester of antibiotic SF-837 or of leucomycin A 3 having the Formula II above together with a pharmaceutically acceptable carrier.
GB3008372A 1971-06-29 1972-06-27 One step process for the production of a mono-ester of macrolide antibiotics Expired GB1358114A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4679671A JPS4925271B1 (en) 1971-06-29 1971-06-29

Publications (1)

Publication Number Publication Date
GB1358114A true GB1358114A (en) 1974-06-26

Family

ID=12757282

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3008372A Expired GB1358114A (en) 1971-06-29 1972-06-27 One step process for the production of a mono-ester of macrolide antibiotics

Country Status (5)

Country Link
JP (1) JPS4925271B1 (en)
CA (1) CA962263A (en)
DE (1) DE2230729C3 (en)
FR (1) FR2186229B1 (en)
GB (1) GB1358114A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5432493A (en) * 1977-08-15 1979-03-09 Meiji Seika Kaisha Ltd Preparation of macrolide antibiotics derivatives

Also Published As

Publication number Publication date
FR2186229B1 (en) 1977-04-15
JPS4925271B1 (en) 1974-06-28
DE2230729B2 (en) 1974-06-20
DE2230729C3 (en) 1975-01-30
CA962263A (en) 1975-02-04
FR2186229A1 (en) 1974-01-11
DE2230729A1 (en) 1973-01-18

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee