GB1350968A - Basically substituted alkyl theophyllines - Google Patents
Basically substituted alkyl theophyllinesInfo
- Publication number
- GB1350968A GB1350968A GB3511671A GB3511671A GB1350968A GB 1350968 A GB1350968 A GB 1350968A GB 3511671 A GB3511671 A GB 3511671A GB 3511671 A GB3511671 A GB 3511671A GB 1350968 A GB1350968 A GB 1350968A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- reaction
- prepared
- hydrogen
- theophylline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000000547 substituted alkyl group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 238000006243 chemical reaction Methods 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical class O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 229960000278 theophylline Drugs 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000000468 ketone group Chemical group 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- KBHSBKOOKXQLAS-UHFFFAOYSA-N 1-[3,4-bis(phenylmethoxy)phenyl]-2-bromoethanol Chemical compound C(C1=CC=CC=C1)OC=1C=C(C=CC1OCC1=CC=CC=C1)C(CBr)O KBHSBKOOKXQLAS-UHFFFAOYSA-N 0.000 abstract 1
- FWKNVYGFFGCWQY-UHFFFAOYSA-N 1-[3,4-bis(phenylmethoxy)phenyl]-2-bromoethanone Chemical compound C=1C=CC=CC=1COC1=CC(C(=O)CBr)=CC=C1OCC1=CC=CC=C1 FWKNVYGFFGCWQY-UHFFFAOYSA-N 0.000 abstract 1
- -1 2 - Methyl - 3 - aminopropyl Chemical group 0.000 abstract 1
- ZBUXSOAUWWXDNS-UHFFFAOYSA-N 4-(3-hydroxyprop-1-ynyl)phenol Chemical compound OCC#CC1=CC=C(O)C=C1 ZBUXSOAUWWXDNS-UHFFFAOYSA-N 0.000 abstract 1
- FCSKOFQQCWLGMV-UHFFFAOYSA-N 5-{5-[2-chloro-4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]pentyl}-3-methylisoxazole Chemical compound O1N=C(C)C=C1CCCCCOC1=CC=C(C=2OCCN=2)C=C1Cl FCSKOFQQCWLGMV-UHFFFAOYSA-N 0.000 abstract 1
- 208000001871 Tachycardia Diseases 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000000440 benzylamino group Chemical group [H]N(*)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 230000001813 broncholytic effect Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000036571 hydration Effects 0.000 abstract 1
- 238000006703 hydration reaction Methods 0.000 abstract 1
- 239000002184 metal Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 230000002829 reductive effect Effects 0.000 abstract 1
- 230000006794 tachycardia Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT686070A AT308139B (de) | 1970-07-27 | 1970-07-27 | Verfahren zur Herstellung von neuen basisch substituierten Alkyltheophyllinen, ihren Isomeren und Säureadditionssalzen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1350968A true GB1350968A (en) | 1974-04-24 |
Family
ID=3590507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3511671A Expired GB1350968A (en) | 1970-07-27 | 1971-07-27 | Basically substituted alkyl theophyllines |
Country Status (13)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9522871B2 (en) | 2006-08-10 | 2016-12-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Preparation of (R,R)-fenoterol and (R,R)-or (R,S)-fenoterol analogues and their use in treating congestive heart failure |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE788427A (fr) * | 1971-09-06 | 1973-03-05 | Degussa | Alkyltheophyllines a substitution basique |
| GB1527543A (en) * | 1976-04-15 | 1978-10-04 | Degussa | Basically substituted xanthine derivatives |
| DE2701629A1 (de) | 1977-01-17 | 1978-07-20 | Degussa | Verfahren zur herstellung von basisch substituierten alkyltheophyllinderivaten |
| AR221879A1 (es) * | 1978-06-23 | 1981-03-31 | Degussa | Procedimiento para la elaboracion de derivados de teofilina |
| CA2791702C (en) | 2010-03-10 | 2018-05-29 | Sri International | The use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3245994A (en) * | 1966-04-12 | Theophylline derivatives |
-
1970
- 1970-07-27 AT AT686070A patent/AT308139B/de not_active IP Right Cessation
-
1971
- 1971-06-07 ES ES391993A patent/ES391993A1/es not_active Expired
- 1971-06-11 NL NL7108037A patent/NL7108037A/xx not_active Application Discontinuation
- 1971-06-17 FI FI1712/71A patent/FI54482C/fi active
- 1971-07-19 DK DK354571AA patent/DK127118B/da not_active IP Right Cessation
- 1971-07-22 DE DE19712136643 patent/DE2136643A1/de not_active Withdrawn
- 1971-07-26 FR FR7127276A patent/FR2100953B1/fr not_active Expired
- 1971-07-26 BE BE770521A patent/BE770521A/xx unknown
- 1971-07-27 GB GB3511671A patent/GB1350968A/en not_active Expired
- 1971-07-27 SE SE7109642A patent/SE381050B/xx unknown
- 1971-07-27 CH CH757974A patent/CH560700A5/xx not_active IP Right Cessation
- 1971-07-27 CA CA119217A patent/CA925870A/en not_active Expired
- 1971-07-27 JP JP5634071A patent/JPS5611715B1/ja active Pending
- 1971-07-27 CH CH1106371A patent/CH555353A/xx not_active IP Right Cessation
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9522871B2 (en) | 2006-08-10 | 2016-12-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Preparation of (R,R)-fenoterol and (R,R)-or (R,S)-fenoterol analogues and their use in treating congestive heart failure |
| US9908841B2 (en) | 2006-08-10 | 2018-03-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Preparation of (R,R)-fenoterol and (R,R)- or (R,S)-fenoterol analogues and their use in treating congestive heart failure |
| US10308591B2 (en) | 2006-08-10 | 2019-06-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Preparation of (R,R)-fenoterol and (R,R)- or (R,S)-fenoterol analogues and their use in treating congestive heart failure |
| US10562843B2 (en) | 2006-08-10 | 2020-02-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Preparation of (R,R)-fenoterol and (R,R)- or (R,S)-fenoterol analogues and their use in treating congestive heart failure |
Also Published As
| Publication number | Publication date |
|---|---|
| CA925870A (en) | 1973-05-08 |
| NL7108037A (enrdf_load_stackoverflow) | 1972-01-31 |
| FR2100953B1 (enrdf_load_stackoverflow) | 1974-11-15 |
| DE2136643A1 (de) | 1972-02-10 |
| JPS5611715B1 (enrdf_load_stackoverflow) | 1981-03-16 |
| FI54482B (fi) | 1978-08-31 |
| DK127118B (da) | 1973-09-24 |
| ES391993A1 (es) | 1973-06-16 |
| FI54482C (fi) | 1978-12-11 |
| AU3138071A (en) | 1973-01-25 |
| SE381050B (sv) | 1975-11-24 |
| CH555353A (de) | 1974-10-31 |
| AT308139B (de) | 1973-06-25 |
| FR2100953A1 (enrdf_load_stackoverflow) | 1972-03-24 |
| CH560700A5 (enrdf_load_stackoverflow) | 1975-04-15 |
| BE770521A (fr) | 1971-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |