GB1350397A - D-homosteroid imides and a process for the preparation thereof - Google Patents
D-homosteroid imides and a process for the preparation thereofInfo
- Publication number
- GB1350397A GB1350397A GB2772071A GB2772071A GB1350397A GB 1350397 A GB1350397 A GB 1350397A GB 2772071 A GB2772071 A GB 2772071A GB 2772071 A GB2772071 A GB 2772071A GB 1350397 A GB1350397 A GB 1350397A
- Authority
- GB
- United Kingdom
- Prior art keywords
- aza
- hydroxy
- pregnan
- june
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
Abstract
1350397 17-Aza-D-homosteroids RICHTER GEDEON VEGYESZETI GYAR RT 14 June 1971 [18 June 1970] 27720/71 Heading C2C The invention comprises compounds of Formulµ I and Ia (wherein R is free or ketalized oxo or is an α- hydrogen atom with a #-esterified or etherified hydroxyl group; and R 2 is C 1-4 alkoxy) and their preparation (a) by Beckmann rearrangement of the corresponding 16-hydroxyimino-17- oxo steroids using a mineral acid; and (b) by base cyclization of the corresponding 13α-X- 14#-CH 2 Y-de-D-steroids (wherein one of X and Y is carbamoyl and the other is alkoxycarbonyl). The starting material for method (a) may also contain a free 3-hydroxy group in which case a subsequent acetylation is performed (Example 2). A 3-ketal group may be hydrolysed during method (a) (Example 3). The inventive compounds are said to be convertible into 3# - hydroxy - 21 - chloro - 17 - aza- 5α - pregnan - 20 - one and 3 - hydroxy - 21- acetoxy - 17 - aza - 5α - pregnan - 20 - one (bactericidal and bacteriostatic agents) and into 3 - methoxy - 21 - (4 - methylpiperazino) - 17 - azapregna-1,3,5(10)-trien-20-one (a hypoeholesterolemic agent).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HURI000392 | 1970-06-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1350397A true GB1350397A (en) | 1974-04-18 |
Family
ID=11000838
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2772071A Expired GB1350397A (en) | 1970-06-18 | 1971-06-14 | D-homosteroid imides and a process for the preparation thereof |
Country Status (11)
Country | Link |
---|---|
JP (1) | JPS4819636B2 (en) |
AT (1) | AT314746B (en) |
BG (1) | BG18620A3 (en) |
CA (1) | CA933150A (en) |
DE (1) | DE2130281A1 (en) |
ES (1) | ES392355A1 (en) |
FR (1) | FR2109619A5 (en) |
GB (1) | GB1350397A (en) |
IL (1) | IL37031A0 (en) |
NL (1) | NL7108384A (en) |
ZA (1) | ZA713785B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8124614B2 (en) | 2001-10-18 | 2012-02-28 | Sterix Limited | Steroidal compounds for inhibiting steroid sulphatase |
CN114773309A (en) * | 2022-04-12 | 2022-07-22 | 乐威医药(天津)有限公司 | Preparation method and application of 1- (7-halobenzo [ D ] [1,3] dioxol-4-yl) alkyl ketone compound |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60209811T2 (en) * | 2001-10-18 | 2006-10-12 | Sterix Ltd., Slough | STEROIDAL COMPOUNDS FOR INHIBITING STEROIDSULFATASES |
-
1971
- 1971-06-09 AT AT502271A patent/AT314746B/en not_active IP Right Cessation
- 1971-06-10 IL IL37031A patent/IL37031A0/en unknown
- 1971-06-11 ZA ZA713785A patent/ZA713785B/en unknown
- 1971-06-14 GB GB2772071A patent/GB1350397A/en not_active Expired
- 1971-06-16 BG BG17827A patent/BG18620A3/xx unknown
- 1971-06-17 FR FR7122082A patent/FR2109619A5/en not_active Expired
- 1971-06-17 ES ES392355A patent/ES392355A1/en not_active Expired
- 1971-06-17 CA CA115928A patent/CA933150A/en not_active Expired
- 1971-06-18 NL NL7108384A patent/NL7108384A/xx unknown
- 1971-06-18 DE DE19712130281 patent/DE2130281A1/en active Pending
- 1971-06-18 JP JP46043849A patent/JPS4819636B2/ja not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8124614B2 (en) | 2001-10-18 | 2012-02-28 | Sterix Limited | Steroidal compounds for inhibiting steroid sulphatase |
CN114773309A (en) * | 2022-04-12 | 2022-07-22 | 乐威医药(天津)有限公司 | Preparation method and application of 1- (7-halobenzo [ D ] [1,3] dioxol-4-yl) alkyl ketone compound |
Also Published As
Publication number | Publication date |
---|---|
AT314746B (en) | 1974-04-25 |
FR2109619A5 (en) | 1972-05-26 |
BG18620A3 (en) | 1975-02-25 |
NL7108384A (en) | 1971-12-21 |
IL37031A0 (en) | 1971-08-25 |
ES392355A1 (en) | 1974-08-01 |
ZA713785B (en) | 1972-01-26 |
DE2130281A1 (en) | 1972-01-27 |
CA933150A (en) | 1973-09-04 |
JPS4819636B2 (en) | 1973-06-14 |
JPS4643849A (en) | 1972-01-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
CSNS | Application of which complete specification have been accepted and published, but patent is not sealed |