GB1344727A - Pharmaceutical preparations comprising chondroitin sulphates a and c - Google Patents
Pharmaceutical preparations comprising chondroitin sulphates a and cInfo
- Publication number
- GB1344727A GB1344727A GB2715771A GB2715771A GB1344727A GB 1344727 A GB1344727 A GB 1344727A GB 2715771 A GB2715771 A GB 2715771A GB 2715771 A GB2715771 A GB 2715771A GB 1344727 A GB1344727 A GB 1344727A
- Authority
- GB
- United Kingdom
- Prior art keywords
- chondroitin
- chondroitin sulphates
- solution
- prolongation
- april
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
1344727 Chondroitin sulphates and compositions thereof L M MORRISON 19 April 1971 [15 April 1970] 27157/71 Heading A5B [Also in Division C3] Chondroitin sulphates A and C capable of causing a prolongation of plasma thrombus formation time 6 to 12 hours after administration in rabbits according to a defined procedure, are used orally (tablets) or by injection for preventing or treating atherosclerosis, particularly in human beings. A unit dose may amount to 0.5-10 g of the so-called biologically active chondroitin sulphates A and C. The compounds may be prepared from bovine trachea or shark cartilage, respectively, by a method broadly comprising defatting the trachea or cartilage, drying and grinding the defatted material, solubilizing the defatted material in a buffered medium containing a proteolytic enzyme and enzyme activators, this mixture being maintained at a temperature of 62‹ Œ 3‹C for not less than 24 hours, precipitating the supernatant with a fat solvent, dissolving the precipitate in isotonic saline to form a weak solution, adding to the solution small amounts of an oxidising agent until there is no further reaction, allowing the solution to stand or adding a small volume of formaldehyde or methanol, followed by a fat solvent, recovering the chondroitin sulphate A or C, testing it for biological activity/prolongation of plasma thrombus-formation time) and bringing it into a form suitable for administration.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2892870A | 1970-04-15 | 1970-04-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1344727A true GB1344727A (en) | 1974-01-23 |
Family
ID=21846276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2715771A Expired GB1344727A (en) | 1970-04-15 | 1971-04-19 | Pharmaceutical preparations comprising chondroitin sulphates a and c |
Country Status (4)
| Country | Link |
|---|---|
| DE (1) | DE2037942C2 (en) |
| ES (1) | ES387885A1 (en) |
| FR (1) | FR2086068B1 (en) |
| GB (1) | GB1344727A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5017565A (en) * | 1989-04-20 | 1991-05-21 | Lange Iii Louis G | Use of sulfated polysaccharides to inhibit pancreatic cholesterol esterase |
| US5063210A (en) * | 1989-04-20 | 1991-11-05 | Lange Iii Louis G | Use of sulfated polysaccharides to decrease cholesterol and fatty acid absorption |
| US5484777A (en) * | 1989-04-20 | 1996-01-16 | Lange, Iii; Louis G. | Pancreatic cholesterol esterase inhibitor |
| CN1304430C (en) * | 2004-08-25 | 2007-03-14 | 淮阴工学院 | Production technology of chondroitin sulphate |
| US7943764B2 (en) | 2005-10-27 | 2011-05-17 | Dimitry Alekseevich Savaschuk | Method for producing sulphated glycosaminoglycans from biological tissues |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2098506B (en) * | 1981-05-14 | 1984-10-03 | Biomed Res Inc | Drug coated materials |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1950100A (en) * | 1932-06-02 | 1934-03-06 | Jr Lathan A Crandall | Chondroitin compounds and their preparation |
| US3405120A (en) * | 1966-01-27 | 1968-10-08 | Green Cross Corp | Low molecular chondroitin sulfate and method for manufacturing the same |
-
1970
- 1970-07-30 DE DE19702037942 patent/DE2037942C2/en not_active Expired
- 1970-08-14 FR FR7030082A patent/FR2086068B1/fr not_active Expired
-
1971
- 1971-02-02 ES ES387885A patent/ES387885A1/en not_active Expired
- 1971-04-19 GB GB2715771A patent/GB1344727A/en not_active Expired
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5017565A (en) * | 1989-04-20 | 1991-05-21 | Lange Iii Louis G | Use of sulfated polysaccharides to inhibit pancreatic cholesterol esterase |
| US5063210A (en) * | 1989-04-20 | 1991-11-05 | Lange Iii Louis G | Use of sulfated polysaccharides to decrease cholesterol and fatty acid absorption |
| US5484777A (en) * | 1989-04-20 | 1996-01-16 | Lange, Iii; Louis G. | Pancreatic cholesterol esterase inhibitor |
| CN1304430C (en) * | 2004-08-25 | 2007-03-14 | 淮阴工学院 | Production technology of chondroitin sulphate |
| US7943764B2 (en) | 2005-10-27 | 2011-05-17 | Dimitry Alekseevich Savaschuk | Method for producing sulphated glycosaminoglycans from biological tissues |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2037942A1 (en) | 1971-11-11 |
| DE2037942C2 (en) | 1982-11-18 |
| FR2086068B1 (en) | 1974-07-12 |
| FR2086068A1 (en) | 1971-12-31 |
| ES387885A1 (en) | 1974-01-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| 732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
| PCNP | Patent ceased through non-payment of renewal fee |