GB1343374A - Pharmaceutical compositions and process for their production - Google Patents
Pharmaceutical compositions and process for their productionInfo
- Publication number
- GB1343374A GB1343374A GB2327472A GB2327472A GB1343374A GB 1343374 A GB1343374 A GB 1343374A GB 2327472 A GB2327472 A GB 2327472A GB 2327472 A GB2327472 A GB 2327472A GB 1343374 A GB1343374 A GB 1343374A
- Authority
- GB
- United Kingdom
- Prior art keywords
- nitroglycerine
- weight
- water
- mixture
- tablets
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 5
- 239000002904 solvent Substances 0.000 abstract 4
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 abstract 3
- 229960003711 glyceryl trinitrate Drugs 0.000 abstract 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 2
- 229930006000 Sucrose Natural products 0.000 abstract 2
- 238000009835 boiling Methods 0.000 abstract 2
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 abstract 2
- 239000008101 lactose Substances 0.000 abstract 2
- 239000005720 sucrose Substances 0.000 abstract 2
- 239000003826 tablet Substances 0.000 abstract 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- ALQSHHUCVQOPAS-UHFFFAOYSA-N Pentane-1,5-diol Chemical compound OCCCCCO ALQSHHUCVQOPAS-UHFFFAOYSA-N 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- 239000003218 coronary vasodilator agent Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000600 sorbitol Substances 0.000 abstract 1
- 239000006190 sub-lingual tablet Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Emergency Medicine (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14907271A | 1971-06-01 | 1971-06-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1343374A true GB1343374A (en) | 1974-01-10 |
Family
ID=22528688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2327472A Expired GB1343374A (en) | 1971-06-01 | 1972-05-17 | Pharmaceutical compositions and process for their production |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US3789119A (enExample) |
| BE (1) | BE784136A (enExample) |
| CA (1) | CA983854A (enExample) |
| FR (1) | FR2140028B1 (enExample) |
| GB (1) | GB1343374A (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4470962A (en) * | 1979-08-14 | 1984-09-11 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix |
| US4482533A (en) * | 1982-01-11 | 1984-11-13 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing propranolol |
| US20130327676A1 (en) * | 2011-02-25 | 2013-12-12 | G. Pohl-Boskamp Gmbh & Co. Kg | Packaging of Solid Pharmaceutical Preparations Containing the Active Substance Glyceryl Trinitrate |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3873727A (en) * | 1971-06-01 | 1975-03-25 | Parke Davis & Co | Stabilization of molded sublingual nitroglycerin tablets |
| DE2246013A1 (de) * | 1972-09-20 | 1974-03-28 | Boehringer Mannheim Gmbh | Verfahren zur herstellung von poroesen tabletten |
| US4091091A (en) * | 1973-11-08 | 1978-05-23 | Eli Lilly And Company | Stabilized nitroglycerin tablets |
| JPS5738569B2 (enExample) * | 1974-03-27 | 1982-08-16 | ||
| DE2556561C2 (de) * | 1975-12-16 | 1983-04-14 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur Herstellung von porösen Tabletten |
| CA1163561A (en) * | 1979-11-06 | 1984-03-13 | Cyril Boroda | Preparation containing nitroglycerine and optionally other medicaments and preparation thereof |
| US5286748A (en) * | 1981-01-05 | 1994-02-15 | Eby Iii George A | General method of shortening the duration of common colds by application of medicaments to tissues of oral cavity |
| DE3109783C2 (de) * | 1981-03-13 | 1987-04-02 | Schwarz GmbH, 4019 Monheim | Verfahren zur Herstellung einer ethanolfreien Nitroglycerinlösung mit einer Konzentration von etwa 1 mg Nitroglycerin/ml |
| US4834979A (en) * | 1981-06-29 | 1989-05-30 | Alza Corporation | Medical bandage for administering beneficial drug |
| US4954344A (en) * | 1981-06-29 | 1990-09-04 | Alza Corporation | Method for treating nocturnal angina |
| US4849226A (en) * | 1981-06-29 | 1989-07-18 | Alza Corporation | Method for increasing oxygen supply by administering vasodilator |
| US4812313A (en) * | 1981-06-29 | 1989-03-14 | Alza Corporation | Method for lessening the incidence of anginal attacks |
| CA1218604A (en) * | 1981-07-08 | 1987-03-03 | Alec D. Keith | Trinitroglycerol sustained release vehicles and preparations therefrom |
| US4846826A (en) * | 1981-07-22 | 1989-07-11 | Alza Corporation | Method for treating ischemic conditions |
| US4486193A (en) * | 1981-07-22 | 1984-12-04 | Alza Corporation | Method for treating ischemic conditions by administering drug by two routes |
| US4562024A (en) * | 1982-07-06 | 1985-12-31 | Sterling Drug Inc. | Process for preparing granulate containing poorly compressible medicinally active matter |
| US4704119A (en) * | 1983-02-03 | 1987-11-03 | Alza Corporation | Method comprising transdermal and buccal treatment of angina |
| JPH06218028A (ja) * | 1992-10-02 | 1994-08-09 | Eisai Co Ltd | 湿製錠の成型方法とその装置及び湿製錠 |
| US6544557B2 (en) | 2001-01-09 | 2003-04-08 | Pan Pharmaceutical Limited | Effervescent tablet compositions |
| WO2005003596A1 (fr) | 2003-07-08 | 2005-01-13 | Planbau Energiesysteme Gmbh & Co. Kg | Entrainement a variation en continu a gamme etendue |
| CN111517960A (zh) * | 2020-05-19 | 2020-08-11 | 启东市新晨企业管理咨询有限公司 | 一种连续化生产的硝酸甘油的片剂 |
| CN114469881A (zh) * | 2022-03-14 | 2022-05-13 | 河北坤安药业有限公司 | 一种硝酸甘油片及其制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1541744A (en) * | 1924-02-18 | 1925-06-09 | Lilly Co Eli | Medicinal tablet |
| US2540253A (en) * | 1949-02-08 | 1951-02-06 | Merck & Co Inc | Granulation process |
| US2648698A (en) * | 1949-07-29 | 1953-08-11 | Hercules Powder Co Ltd | Desensitized liquid explosives |
| US2698822A (en) * | 1951-04-28 | 1955-01-04 | Fougera & Co Inc E | Cardiac glycoside buccal composition |
| US3028307A (en) * | 1959-05-27 | 1962-04-03 | Warner Lambert Pharmaceutical | Pre-dried granulation and production of sublingual compressed organic nitrate tablets with selected solubilizing agents |
| US3511914A (en) * | 1967-01-31 | 1970-05-12 | Schering Corp | Throat lozenge vehicle |
-
1971
- 1971-06-01 US US00149072A patent/US3789119A/en not_active Expired - Lifetime
-
1972
- 1972-05-10 CA CA141,800A patent/CA983854A/en not_active Expired
- 1972-05-17 GB GB2327472A patent/GB1343374A/en not_active Expired
- 1972-05-29 FR FR7219103A patent/FR2140028B1/fr not_active Expired
- 1972-05-29 BE BE784136A patent/BE784136A/xx not_active IP Right Cessation
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4470962A (en) * | 1979-08-14 | 1984-09-11 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix |
| US4482533A (en) * | 1982-01-11 | 1984-11-13 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing propranolol |
| US20130327676A1 (en) * | 2011-02-25 | 2013-12-12 | G. Pohl-Boskamp Gmbh & Co. Kg | Packaging of Solid Pharmaceutical Preparations Containing the Active Substance Glyceryl Trinitrate |
Also Published As
| Publication number | Publication date |
|---|---|
| BE784136A (fr) | 1972-09-18 |
| DE2226322A1 (de) | 1972-12-14 |
| CA983854A (en) | 1976-02-17 |
| US3789119A (en) | 1974-01-29 |
| FR2140028B1 (enExample) | 1975-06-20 |
| DE2226322B2 (de) | 1976-04-22 |
| FR2140028A1 (enExample) | 1973-01-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
| PE20 | Patent expired after termination of 20 years |