GB1342042A - 16beta-hydrocarbon substituted estrane compounds - Google Patents
16beta-hydrocarbon substituted estrane compoundsInfo
- Publication number
- GB1342042A GB1342042A GB60771A GB60771A GB1342042A GB 1342042 A GB1342042 A GB 1342042A GB 60771 A GB60771 A GB 60771A GB 60771 A GB60771 A GB 60771A GB 1342042 A GB1342042 A GB 1342042A
- Authority
- GB
- United Kingdom
- Prior art keywords
- prepared
- methoxy
- steroids
- ethylestra
- trien
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000004215 Carbon black (E152) Substances 0.000 title abstract 2
- 150000002162 estranes Chemical class 0.000 title 1
- 230000007062 hydrolysis Effects 0.000 abstract 3
- 238000006460 hydrolysis reaction Methods 0.000 abstract 3
- 238000006722 reduction reaction Methods 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 150000003431 steroids Chemical class 0.000 abstract 2
- 235000018185 Betula X alpestris Nutrition 0.000 abstract 1
- 235000018212 Betula X uliginosa Nutrition 0.000 abstract 1
- 238000006027 Birch reduction reaction Methods 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000002280 anti-androgenic effect Effects 0.000 abstract 1
- 239000000051 antiandrogen Substances 0.000 abstract 1
- 229940030495 antiandrogen sex hormone and modulator of the genital system Drugs 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
- HJKVPZJVBHWFCQ-BDXSIMOUSA-N estra-1,3,5(10)-trien-3-ol Chemical class C1CC2=CC(O)=CC=C2[C@@H]2[C@@H]1[C@@H]1CCC[C@@]1(C)CC2 HJKVPZJVBHWFCQ-BDXSIMOUSA-N 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- FRIJBUGBVQZNTB-UHFFFAOYSA-M magnesium;ethane;bromide Chemical compound [Mg+2].[Br-].[CH2-]C FRIJBUGBVQZNTB-UHFFFAOYSA-M 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5748570A JPS4916858B1 (enrdf_load_stackoverflow) | 1970-07-01 | 1970-07-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1342042A true GB1342042A (en) | 1973-12-25 |
Family
ID=13056999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB60771A Expired GB1342042A (en) | 1970-07-01 | 1971-01-06 | 16beta-hydrocarbon substituted estrane compounds |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPS4916858B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1342042A (enrdf_load_stackoverflow) |
-
1970
- 1970-07-01 JP JP5748570A patent/JPS4916858B1/ja active Pending
-
1971
- 1971-01-06 GB GB60771A patent/GB1342042A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS4916858B1 (enrdf_load_stackoverflow) | 1974-04-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PE20 | Patent expired after termination of 20 years |