GB1341222A - Oxadiazole derivatives - Google Patents
Oxadiazole derivativesInfo
- Publication number
- GB1341222A GB1341222A GB138771A GB138771A GB1341222A GB 1341222 A GB1341222 A GB 1341222A GB 138771 A GB138771 A GB 138771A GB 138771 A GB138771 A GB 138771A GB 1341222 A GB1341222 A GB 1341222A
- Authority
- GB
- United Kingdom
- Prior art keywords
- benzamidoxime
- formula
- oxadiazole derivatives
- compounds
- ethoxycarbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
Abstract
1341222 Oxadiazole derivatives TAKEDA YAKUHIN KOGYO KK 12 Jan 1971 [14 Jan 1970 17 April 1970] 1387/71 Heading C2C Novel oxadiazole derivatives of the formula wherein X is a free or esterified carboxy group or an unsubstituted or substituted carbamoyl group, R<SP>1</SP> and R<SP>2</SP> each are H, alkenyl, alkynyl, cycloalkyl, alkyl or aryl and R<SP>3</SP> is an optionally substituted hydrocarbon or heterocyclic group, and pharmaceutically acceptable salts thereof, are prepared by reacting compounds of the formula with carboxylic acids of the formula R<SP>3</SP>COOH or acid halides, acid anhydrides or esters thereof. 4 - (1 - Ethoxycarbonyl - 1 - methylethoxy) benzamidoxime, 4 - (1 - ethoxycarbonylethoxy) benzamidoxime, 4 - (1 - ethoxycarbonylpentyl) benzamidoxime, 4 - (α - ethoxycarbonylbenzyloxy) benzamidoxime and 4 - (1 - ethoxycarbonyl-1- cyclohexylmethoxy) benzamidoxime are obtained by hydroxylamine hydrochloride with the corresponding benzonitriles. Pharmaceutical compositions, suitable for oral or parenteral administration, contain the above novel compounds or acceptable salts thereof, together with pharmaceutically acceptable carriers, diluents or adjuvants. The compounds have hypocholesterolemic activity.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3334070 | 1970-04-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1341222A true GB1341222A (en) | 1973-12-19 |
Family
ID=12383821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB138771A Expired GB1341222A (en) | 1970-04-17 | 1971-01-12 | Oxadiazole derivatives |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1341222A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5356916A (en) * | 1991-03-22 | 1994-10-18 | Wakamoto Pharmaceutical Co., Ltd. | 1,2,4-oxadiazole derivatives having monoamine oxidase B enzyme-inhibitory activity |
| JP2005520858A (en) * | 2002-03-20 | 2005-07-14 | メタボレックス， インコーポレイテッド | Substituted phenylacetic acid |
| JP2006516250A (en) * | 2002-12-18 | 2006-06-29 | サイトビア インコーポレイティッド | 3,5-disubstituted- [1,2,4] -oxadiazoles and their derivatives and their use as caspase activators and apoptosis inducers |
-
1971
- 1971-01-12 GB GB138771A patent/GB1341222A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5356916A (en) * | 1991-03-22 | 1994-10-18 | Wakamoto Pharmaceutical Co., Ltd. | 1,2,4-oxadiazole derivatives having monoamine oxidase B enzyme-inhibitory activity |
| JP2005520858A (en) * | 2002-03-20 | 2005-07-14 | メタボレックス， インコーポレイテッド | Substituted phenylacetic acid |
| JP2006516250A (en) * | 2002-12-18 | 2006-06-29 | サイトビア インコーポレイティッド | 3,5-disubstituted- [1,2,4] -oxadiazoles and their derivatives and their use as caspase activators and apoptosis inducers |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |