GB1335931A - Azepine derivatives - Google Patents
Azepine derivativesInfo
- Publication number
- GB1335931A GB1335931A GB1440671*[A GB1440671A GB1335931A GB 1335931 A GB1335931 A GB 1335931A GB 1440671 A GB1440671 A GB 1440671A GB 1335931 A GB1335931 A GB 1335931A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- formula
- prepared
- chloro
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
- C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/02—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with only hydrogen, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/06—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1335931 Dibenzazepines CIBA-GEIGY AG 12 May 1971 [13 May 1970] 14406/71 Heading C2C Dibenzazepine derivatives (most of which are novel) of Formula I (in which R is H or CH 3 , X 1 is H, Cl or CF 3 and X 2 is H, or when X 1 is H, also Cl) are prepared by dehydrating and rearranging a compound of Formula IV accroding to Wagner-Meerwein, pref. by treating the compound IV with 70-90% sulphuric acid. The novel compounds are those in which R, X 1 and X 2 have the above meanings, except that they are not all simultaneously H. Compounds IV are prepared by reacting a compound of Formula II or a corresponding 10-methyl-acridinium compound, with acetaldehyde, to give a compound of Formula III and reducing this compound III. 3 - Chloro - 9 - methyl - acridine hydrobromide is prepared by reacting 3-chloro-5H-dibenz- [b,f]azepine with hydrobromic acid.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH706870A CH533117A (en) | 1970-05-13 | 1970-05-13 | Process for the production of azepine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1335931A true GB1335931A (en) | 1973-10-31 |
Family
ID=4319418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1440671*[A Expired GB1335931A (en) | 1970-05-13 | 1971-05-12 | Azepine derivatives |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS5610307B1 (en) |
| AT (1) | AT306729B (en) |
| BE (1) | BE767060A (en) |
| CA (1) | CA988515A (en) |
| CH (1) | CH533117A (en) |
| CS (1) | CS154690B2 (en) |
| DE (1) | DE2123569C3 (en) |
| ES (1) | ES391055A1 (en) |
| FR (1) | FR2088537B1 (en) |
| GB (1) | GB1335931A (en) |
| IL (1) | IL36831A (en) |
| NL (1) | NL167422C (en) |
| PL (1) | PL91132B1 (en) |
| SE (1) | SE368202B (en) |
| SU (1) | SU382283A3 (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3016373A (en) * | 1962-01-09 | Process for the preparation of | ||
| FR2043486B1 (en) * | 1969-05-28 | 1973-07-13 | Roussel Uclaf |
-
1970
- 1970-05-13 CH CH706870A patent/CH533117A/en not_active IP Right Cessation
-
1971
- 1971-05-06 NL NL7106224.A patent/NL167422C/en not_active IP Right Cessation
- 1971-05-06 SE SE05883/71A patent/SE368202B/xx unknown
- 1971-05-11 SU SU1656558A patent/SU382283A3/ru active
- 1971-05-12 AT AT411771A patent/AT306729B/en not_active IP Right Cessation
- 1971-05-12 JP JP3320571A patent/JPS5610307B1/ja active Pending
- 1971-05-12 BE BE767060A patent/BE767060A/en unknown
- 1971-05-12 PL PL1971148115A patent/PL91132B1/pl unknown
- 1971-05-12 CA CA112,762A patent/CA988515A/en not_active Expired
- 1971-05-12 GB GB1440671*[A patent/GB1335931A/en not_active Expired
- 1971-05-12 ES ES391055A patent/ES391055A1/en not_active Expired
- 1971-05-12 IL IL36831A patent/IL36831A/en unknown
- 1971-05-12 CS CS346171A patent/CS154690B2/cs unknown
- 1971-05-12 FR FR7117122A patent/FR2088537B1/fr not_active Expired
- 1971-05-12 DE DE2123569A patent/DE2123569C3/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| SE368202B (en) | 1974-06-24 |
| PL91132B1 (en) | 1977-02-28 |
| NL7106224A (en) | 1971-11-16 |
| DE2123569A1 (en) | 1971-11-25 |
| CH533117A (en) | 1973-01-31 |
| IL36831A0 (en) | 1971-07-28 |
| CA988515A (en) | 1976-05-04 |
| FR2088537B1 (en) | 1973-10-19 |
| DE2123569B2 (en) | 1980-03-20 |
| IL36831A (en) | 1974-07-31 |
| JPS5610307B1 (en) | 1981-03-06 |
| SU382283A3 (en) | 1973-05-22 |
| NL167422C (en) | 1981-12-16 |
| BE767060A (en) | 1971-11-12 |
| FR2088537A1 (en) | 1972-01-07 |
| NL167422B (en) | 1981-07-16 |
| DE2123569C3 (en) | 1980-11-13 |
| ES391055A1 (en) | 1973-07-01 |
| CS154690B2 (en) | 1974-04-30 |
| AT306729B (en) | 1973-04-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |