GB1325742A - Pharmaceutical preparations - Google Patents

Pharmaceutical preparations

Info

Publication number
GB1325742A
GB1325742A GB4906370A GB4906370A GB1325742A GB 1325742 A GB1325742 A GB 1325742A GB 4906370 A GB4906370 A GB 4906370A GB 4906370 A GB4906370 A GB 4906370A GB 1325742 A GB1325742 A GB 1325742A
Authority
GB
United Kingdom
Prior art keywords
melt
droplets
oct
sustained release
active compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4906370A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Farbwerke Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG, Farbwerke Hoechst AG filed Critical Hoechst AG
Publication of GB1325742A publication Critical patent/GB1325742A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

1325742 Sustained release compositions FARBWERKE HOECHST AG 15 Oct 1970 [17 Oct 1969] 49063/70 Heading A5B Sustained release pharmaceutical preparations which melt or soften above body temperature are made by (a) forming a melt comprising a pharmacologically active compound and a thermosoftening carrier in suitable proportions, (b) forming the melt into droplets, (c) cooling the droplets and (d) further processing the droplets without shaping them. The active compound may be phenylethyl-biguanide hydrochloride, 4-chloro-N-(2-furylmethyl) -5-sulphamoyl-anthranilic acid, or 1-phenyl-1- (2-pyridyl)-3-(dimethylamino) propane maleate. The carrier may be a glycol or polyglycol wax acid ester, a wax alcohol or a fatty acid amide. The melt may also include a surface active agent, e.g. polyoxyethylene stearate, polyoxyethylene sorbitan mono-oleate, or polyoxyethylene sorbitan monostearate, water-soluble inorganic compounds, polyvinyl pyrrolidone, and/or lecithine. It may be a eutectic mixture. The droplets of melt may be cooled in air, or in a liquid, e.g. a mixture of n-hexane, liquid paraffin and a proprietary refrigerant. The solidified droplets may be administered in capsules.
GB4906370A 1969-10-17 1970-10-15 Pharmaceutical preparations Expired GB1325742A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19691952304 DE1952304A1 (en) 1969-10-17 1969-10-17 Process for the production of a dosage form with controlled release of active ingredients

Publications (1)

Publication Number Publication Date
GB1325742A true GB1325742A (en) 1973-08-08

Family

ID=5748430

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4906370A Expired GB1325742A (en) 1969-10-17 1970-10-15 Pharmaceutical preparations

Country Status (10)

Country Link
AR (1) AR193341A1 (en)
AT (1) AT317433B (en)
BE (1) BE757586A (en)
CA (1) CA937866A (en)
DE (1) DE1952304A1 (en)
ES (1) ES384611A1 (en)
FR (1) FR2070141B1 (en)
GB (1) GB1325742A (en)
NL (1) NL7014922A (en)
ZA (1) ZA707072B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2118040A (en) * 1982-02-15 1983-10-26 Hoechst Uk Ltd Oral anti-diabetic preparation

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU520409B2 (en) * 1977-05-25 1982-01-28 Commonwealth Scientific And Industrial Research Organisation Controlled release composition
DE3124983A1 (en) * 1981-06-25 1983-01-20 Meditest Inst Fuer Medizinisch ORAL ADMINISTRATIVE FORMS
DE3833446A1 (en) * 1988-10-01 1990-04-05 Hoechst Ag METHOD FOR THE PRODUCTION OF MEDICAMENT PARTICLES WITH IMPROVED FLUID, STORAGE AND FORMULATION PROPERTIES AND MEDICAMENTS CONTAINING SUCH MEDICAMENT PARTICLES

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1175826B (en) * 1959-10-23 1964-08-13 Olin Mathieson Process for the manufacture of medicinal preparations for oral administration
GB1073718A (en) * 1964-06-25 1967-06-28 Smith Kline French Lab Improvements relating to the production of sustained-release pharmaceutical pellets
NL7004971A (en) * 1969-04-12 1970-10-14

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2118040A (en) * 1982-02-15 1983-10-26 Hoechst Uk Ltd Oral anti-diabetic preparation

Also Published As

Publication number Publication date
ZA707072B (en) 1971-09-29
NL7014922A (en) 1971-04-20
FR2070141A1 (en) 1971-09-10
AR193341A1 (en) 1973-04-23
CA937866A (en) 1973-12-04
BE757586A (en) 1971-04-15
AT317433B (en) 1974-08-26
ES384611A1 (en) 1973-06-01
DE1952304A1 (en) 1971-05-06
FR2070141B1 (en) 1974-04-12

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees