GB1323785A - Method of producing 5-fluorouracil - Google Patents
Method of producing 5-fluorouracilInfo
- Publication number
- GB1323785A GB1323785A GB4370571A GB4370571A GB1323785A GB 1323785 A GB1323785 A GB 1323785A GB 4370571 A GB4370571 A GB 4370571A GB 4370571 A GB4370571 A GB 4370571A GB 1323785 A GB1323785 A GB 1323785A
- Authority
- GB
- United Kingdom
- Prior art keywords
- fluorouracil
- dihydrouracil
- institut
- acetoxy
- sept
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 title abstract 4
- 229960002949 fluorouracil Drugs 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- DHCMCKURNMYGIJ-UHFFFAOYSA-N (5-fluoro-2,6-dioxo-1,3-diazinan-4-yl) acetate Chemical compound CC(=O)OC1NC(=O)NC(=O)C1F DHCMCKURNMYGIJ-UHFFFAOYSA-N 0.000 abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 229960000583 acetic acid Drugs 0.000 abstract 1
- 238000003682 fluorination reaction Methods 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 239000007789 gas Substances 0.000 abstract 1
- 239000012362 glacial acetic acid Substances 0.000 abstract 1
- 239000011261 inert gas Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229940035893 uracil Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU1472781A SU322053A1 (ru) | 1970-09-24 | Способ получения 5-фторурацила |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1323785A true GB1323785A (en) | 1973-07-18 |
Family
ID=20456938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4370571A Expired GB1323785A (en) | 1970-09-24 | 1971-09-20 | Method of producing 5-fluorouracil |
Country Status (7)
| Country | Link |
|---|---|
| BE (1) | BE772867A (enrdf_load_stackoverflow) |
| CH (1) | CH572043A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2145892C3 (enrdf_load_stackoverflow) |
| FR (1) | FR2107933B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1323785A (enrdf_load_stackoverflow) |
| NL (1) | NL7112865A (enrdf_load_stackoverflow) |
| SE (1) | SE386442B (enrdf_load_stackoverflow) |
-
1971
- 1971-09-14 DE DE19712145892 patent/DE2145892C3/de not_active Expired
- 1971-09-20 NL NL7112865A patent/NL7112865A/xx unknown
- 1971-09-20 GB GB4370571A patent/GB1323785A/en not_active Expired
- 1971-09-20 CH CH1371071A patent/CH572043A5/xx not_active IP Right Cessation
- 1971-09-21 SE SE1194171A patent/SE386442B/xx unknown
- 1971-09-21 BE BE772867A patent/BE772867A/xx unknown
- 1971-09-23 FR FR7134248A patent/FR2107933B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BE772867A (fr) | 1972-03-21 |
| FR2107933A1 (enrdf_load_stackoverflow) | 1972-05-12 |
| SE386442B (sv) | 1976-08-09 |
| NL7112865A (enrdf_load_stackoverflow) | 1972-03-28 |
| FR2107933B1 (enrdf_load_stackoverflow) | 1975-02-07 |
| CH572043A5 (enrdf_load_stackoverflow) | 1976-01-30 |
| DE2145892C3 (de) | 1975-10-09 |
| DE2145892B2 (de) | 1975-02-13 |
| DE2145892A1 (de) | 1972-03-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |