GB1322136A - Ara-cytidine derivatives - Google Patents
Ara-cytidine derivativesInfo
- Publication number
- GB1322136A GB1322136A GB5936871A GB5936871A GB1322136A GB 1322136 A GB1322136 A GB 1322136A GB 5936871 A GB5936871 A GB 5936871A GB 5936871 A GB5936871 A GB 5936871A GB 1322136 A GB1322136 A GB 1322136A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- formula
- prepared
- esters
- diesters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical class O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 12
- 239000002253 acid Substances 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 3
- 230000010933 acylation Effects 0.000 abstract 2
- 238000005917 acylation reaction Methods 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 230000007062 hydrolysis Effects 0.000 abstract 2
- 238000006460 hydrolysis reaction Methods 0.000 abstract 2
- 230000003301 hydrolyzing effect Effects 0.000 abstract 2
- -1 hydroxy, carboxyl Chemical group 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000000926 separation method Methods 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 230000006179 O-acylation Effects 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 230000001188 anti-phage Effects 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229960000684 cytarabine Drugs 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 229960003444 immunosuppressant agent Drugs 0.000 abstract 1
- 230000001861 immunosuppressant effect Effects 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000006386 neutralization reaction Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical group [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11031271A | 1971-01-27 | 1971-01-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1322136A true GB1322136A (en) | 1973-07-04 |
Family
ID=22332340
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5936871A Expired GB1322136A (en) | 1971-01-27 | 1971-12-21 | Ara-cytidine derivatives |
Country Status (6)
| Country | Link |
|---|---|
| AU (1) | AU456952B2 (enrdf_load_stackoverflow) |
| BE (1) | BE778564A (enrdf_load_stackoverflow) |
| DE (1) | DE2202518A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2123441B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1322136A (enrdf_load_stackoverflow) |
| NL (1) | NL7200785A (enrdf_load_stackoverflow) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE399559B (sv) * | 1972-03-03 | 1978-02-20 | Syntex Corp | Sett att framstella oÿ2,2'-cyklocytidinforeningar |
| US3998807A (en) * | 1972-03-03 | 1976-12-21 | Syntex (U.S.A.) Inc. | Arabinofuranosyl cytosines and methods of making |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3284440A (en) * | 1964-06-12 | 1966-11-08 | Merck & Co Inc | Phosphate esters of cytosine arabinoide and process for preparing same |
-
1971
- 1971-12-21 GB GB5936871A patent/GB1322136A/en not_active Expired
- 1971-12-31 AU AU37512/71A patent/AU456952B2/en not_active Expired
-
1972
- 1972-01-20 DE DE19722202518 patent/DE2202518A1/de active Pending
- 1972-01-20 NL NL7200785A patent/NL7200785A/xx unknown
- 1972-01-26 FR FR7202592A patent/FR2123441B1/fr not_active Expired
- 1972-01-27 BE BE778564A patent/BE778564A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BE778564A (fr) | 1972-07-27 |
| AU456952B2 (en) | 1975-01-16 |
| FR2123441B1 (enrdf_load_stackoverflow) | 1975-10-10 |
| FR2123441A1 (enrdf_load_stackoverflow) | 1972-09-08 |
| NL7200785A (enrdf_load_stackoverflow) | 1972-07-31 |
| AU3751271A (en) | 1973-07-05 |
| DE2202518A1 (de) | 1972-08-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |