GB1314293A - Prostaglandins and the preparation thereof - Google Patents
Prostaglandins and the preparation thereofInfo
- Publication number
- GB1314293A GB1314293A GB4292972A GB4292971A GB1314293A GB 1314293 A GB1314293 A GB 1314293A GB 4292972 A GB4292972 A GB 4292972A GB 4292971 A GB4292971 A GB 4292971A GB 1314293 A GB1314293 A GB 1314293A
- Authority
- GB
- United Kingdom
- Prior art keywords
- denotes
- alkyl
- cis
- silylated
- trans
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003180 prostaglandins Chemical class 0.000 title abstract 3
- 229940094443 oxytocics prostaglandins Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
1314293 Silylated prostaglandin derivatives UPJOHN CO 4 May 1971 [4 May 1970 (2) 14 May 1970 (2)] 42929/72 Divided out of 1314291 Heading C3S Novel silylated prostaglandin derivatives of the formula including mirror image forms and corresponding racemates, wherein X denotes trans-CH= CH- or -CH 2 -CH 2 -, and Y and Z both denote -CH 2 -CH 2 -, or wherein X denotes trans-CH=CH-, Y denotes cis-CH=CH-, and Z denotes -CH 2 -CH 2 - or cis-CH= CH-, A denotes C 1-4 alkyl, C 7-12 aralkyl, phenyl or phenyl substituted with one or two fluoro, chloro and/or C 1-4 alkyl, R 3 denotes C 1-8 alkyl or -Si-(A) 3 , and # indicates attachment of (A) 3 -Si-O- to the ring in alpha or beta configuration, are prepared by silylating a compound of the formula (wherein R 4 denotes hydrogen or C 1-8 alkyl). Uses.-Intermediates for pharmaceutical compounds.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3454970A | 1970-05-04 | 1970-05-04 | |
| US3451870A | 1970-05-04 | 1970-05-04 | |
| US3730870A | 1970-05-14 | 1970-05-14 | |
| US3730770A | 1970-05-14 | 1970-05-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1314293A true GB1314293A (en) | 1973-04-18 |
Family
ID=27488226
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4292972A Expired GB1314293A (en) | 1970-05-04 | 1971-05-04 | Prostaglandins and the preparation thereof |
| GB1289871*[A Expired GB1314291A (en) | 1970-05-04 | 1971-05-04 | Prostaglandins and the preparation thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1289871*[A Expired GB1314291A (en) | 1970-05-04 | 1971-05-04 | Prostaglandins and the preparation thereof |
Country Status (9)
| Country | Link |
|---|---|
| CA (1) | CA959485A (en) |
| DE (2) | DE2121980C3 (en) |
| FR (1) | FR2100627B1 (en) |
| GB (2) | GB1314293A (en) |
| IL (1) | IL36682A (en) |
| MY (1) | MY7400305A (en) |
| NL (1) | NL154729B (en) |
| NO (2) | NO135935C (en) |
| SE (1) | SE388852B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2258668C3 (en) * | 1971-12-03 | 1981-08-06 | Syntex Corp., Panama-City | New prostaglandins, processes for their production and pharmaceuticals containing them |
| US3887587A (en) * | 1972-04-17 | 1975-06-03 | Pfizer | Synthesis of prostaglandins of the one-series |
-
1971
- 1971-04-15 CA CA110,447A patent/CA959485A/en not_active Expired
- 1971-04-21 IL IL36682A patent/IL36682A/en unknown
- 1971-04-29 SE SE7105577A patent/SE388852B/en unknown
- 1971-05-03 NL NL717105999A patent/NL154729B/en not_active IP Right Cessation
- 1971-05-03 NO NO1638/71A patent/NO135935C/no unknown
- 1971-05-03 FR FR7115790A patent/FR2100627B1/fr not_active Expired
- 1971-05-04 DE DE2121980A patent/DE2121980C3/en not_active Expired
- 1971-05-04 GB GB4292972A patent/GB1314293A/en not_active Expired
- 1971-05-04 DE DE2166630A patent/DE2166630C3/en not_active Expired
- 1971-05-04 GB GB1289871*[A patent/GB1314291A/en not_active Expired
-
1972
- 1972-06-13 NO NO2080/72A patent/NO140422C/en unknown
-
1974
- 1974-12-30 MY MY305/74A patent/MY7400305A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE388852B (en) | 1976-10-18 |
| NO140422C (en) | 1979-08-29 |
| DE2121980B2 (en) | 1979-06-07 |
| NO135935C (en) | 1977-06-29 |
| DE2166630B2 (en) | 1979-02-22 |
| CA959485A (en) | 1974-12-17 |
| NO135935B (en) | 1977-03-21 |
| MY7400305A (en) | 1974-12-31 |
| FR2100627A1 (en) | 1972-03-24 |
| NL7105999A (en) | 1971-11-08 |
| DE2166630A1 (en) | 1974-12-12 |
| NL154729B (en) | 1977-10-17 |
| DE2166630C3 (en) | 1979-10-11 |
| IL36682A (en) | 1976-04-30 |
| GB1314291A (en) | 1973-04-18 |
| NO140422B (en) | 1979-05-21 |
| FR2100627B1 (en) | 1981-12-18 |
| DE2121980C3 (en) | 1980-02-14 |
| IL36682A0 (en) | 1971-06-23 |
| DE2121980A1 (en) | 1971-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |