GB1314019A - Antibiotic substance and process for the extraction of such an antibiotic substance from a strain of pseudomonas - Google Patents
Antibiotic substance and process for the extraction of such an antibiotic substance from a strain of pseudomonasInfo
- Publication number
- GB1314019A GB1314019A GB3642869A GB1314019DA GB1314019A GB 1314019 A GB1314019 A GB 1314019A GB 3642869 A GB3642869 A GB 3642869A GB 1314019D A GB1314019D A GB 1314019DA GB 1314019 A GB1314019 A GB 1314019A
- Authority
- GB
- United Kingdom
- Prior art keywords
- antibiotic
- pseudomonas
- extracted
- rollandi
- july
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G11/00—Antibiotics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Compounds Of Unknown Constitution (AREA)
- Drying Of Solid Materials (AREA)
Abstract
1314019 Antibiotics from Pseudomocas Rollandi ALBERT ROLLAND SA 17 July 1970 [19 July 1969] 36428/69 Heading C2A In a process for producing an antibiotic whose infra-red spectrum is shown in Fig. 3, a strain of Pseudomonas Rollandi is aerobically cultured at 12-42 C., preferably 28 to 37 C., in a culture medium for a sufficient period of time to achieve the stationary growth phase of the Pseudomonas, the resulting Pseudomonas is then separated and ground, the resulting ground material is dehydrated, and the dehydrated material is extracted with methanol to give a methanolic solution of the crude antibiotic. The methanolic extract may be evaporated to dryness, extracted with a chlorinated solvent, e.g. chloroform, methylene chloride or trichloroacetic acid, followed by, or preceded by treatment with hexane or heptane to remove lipids. The resultant product may be extracted with ethanol to purify the antibiotic still further. The antibiotic comprises a peptide-ester or a depsipeptide component of average molecular weight 1000 to 2000, which can be isolated as slightly beige crystals, m.p. 155-156 C., αD (measured at 20 C. in ethanol) = - 46 degrees and having the infra-red spectrum shown in Fig. 3 of the accompanying drawings and a second component which is a mixture or complex of dipeptide and in part depsi-peptide character, which can be isolated in a semi-crystalline, ninhydrinpositive form, which is soluble in dilute acetic acid and has an Rf of 0À35 on a cellulose plate when using the solvent system butanol-acetic acid-water, 12 : 3 : 5. Pharmaceutical compositions having antibiotic properties contain an antibiotic as described above in conjunction with a pharmaceutically acceptable excipient or carrier.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3642869 | 1969-07-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1314019A true GB1314019A (en) | 1973-04-18 |
Family
ID=10388054
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3642869A Expired GB1314019A (en) | 1969-07-19 | 1969-07-19 | Antibiotic substance and process for the extraction of such an antibiotic substance from a strain of pseudomonas |
Country Status (20)
Country | Link |
---|---|
JP (1) | JPS5034638B1 (en) |
AT (1) | AT296505B (en) |
BE (1) | BE753101A (en) |
CA (1) | CA922251A (en) |
CH (1) | CH513240A (en) |
CS (1) | CS172331B2 (en) |
DE (1) | DE2034799A1 (en) |
DK (1) | DK127194B (en) |
ES (1) | ES381751A1 (en) |
FI (1) | FI46629C (en) |
FR (1) | FR2059533B1 (en) |
GB (1) | GB1314019A (en) |
IL (1) | IL34909A (en) |
LU (1) | LU61361A1 (en) |
NL (1) | NL7010736A (en) |
NO (1) | NO131941C (en) |
OA (1) | OA03642A (en) |
RO (1) | RO56893A (en) |
SE (1) | SE382074B (en) |
ZA (1) | ZA704837B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6573074B2 (en) * | 2000-04-12 | 2003-06-03 | Smithkline Beecham Plc | Methods for ansamitocin production |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL30058A (en) * | 1967-08-10 | 1972-09-28 | Lilly Co Eli | Process for preparing antibiotic a10388(pyrrolnitrin) |
-
1969
- 1969-07-19 GB GB3642869A patent/GB1314019A/en not_active Expired
-
1970
- 1970-07-07 FR FR707025200A patent/FR2059533B1/fr not_active Expired
- 1970-07-07 BE BE753101D patent/BE753101A/en unknown
- 1970-07-13 IL IL34909A patent/IL34909A/en unknown
- 1970-07-14 ZA ZA704837A patent/ZA704837B/en unknown
- 1970-07-14 CA CA088101A patent/CA922251A/en not_active Expired
- 1970-07-14 DE DE19702034799 patent/DE2034799A1/en active Pending
- 1970-07-14 CH CH1066170A patent/CH513240A/en not_active IP Right Cessation
- 1970-07-14 ES ES381751A patent/ES381751A1/en not_active Expired
- 1970-07-16 AT AT06474/70A patent/AT296505B/en not_active IP Right Cessation
- 1970-07-16 OA OA53981A patent/OA03642A/en unknown
- 1970-07-16 NO NO2790/70A patent/NO131941C/no unknown
- 1970-07-17 SE SE7009930A patent/SE382074B/en unknown
- 1970-07-17 FI FI702016A patent/FI46629C/en active
- 1970-07-17 DK DK371570AA patent/DK127194B/en unknown
- 1970-07-17 CS CS5073A patent/CS172331B2/cs unknown
- 1970-07-17 LU LU61361D patent/LU61361A1/xx unknown
- 1970-07-18 JP JP45062757A patent/JPS5034638B1/ja active Pending
- 1970-07-18 RO RO63964A patent/RO56893A/ro unknown
- 1970-07-20 NL NL7010736A patent/NL7010736A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
LU61361A1 (en) | 1970-09-21 |
FI46629B (en) | 1973-01-31 |
SE382074B (en) | 1976-01-12 |
ES381751A1 (en) | 1972-11-16 |
AT296505B (en) | 1972-01-15 |
CH513240A (en) | 1971-09-30 |
ZA704837B (en) | 1971-04-28 |
CA922251A (en) | 1973-03-06 |
RO56893A (en) | 1974-12-15 |
NO131941B (en) | 1975-05-20 |
IL34909A0 (en) | 1970-09-17 |
FI46629C (en) | 1973-05-08 |
DK127194B (en) | 1973-10-01 |
IL34909A (en) | 1973-08-29 |
BE753101A (en) | 1970-12-16 |
DE2034799A1 (en) | 1971-02-04 |
JPS5034638B1 (en) | 1975-11-10 |
FR2059533A1 (en) | 1971-06-04 |
FR2059533B1 (en) | 1974-06-14 |
NL7010736A (en) | 1971-01-21 |
OA03642A (en) | 1971-12-24 |
CS172331B2 (en) | 1976-12-29 |
NO131941C (en) | 1975-08-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
435 | Patent endorsed 'licences of right' on the date specified (sect. 35/1949) | ||
PCNP | Patent ceased through non-payment of renewal fee |