GB1309669A - Lincomycin derivatives and the manufacture thereof - Google Patents
Lincomycin derivatives and the manufacture thereofInfo
- Publication number
- GB1309669A GB1309669A GB4294770A GB4294770A GB1309669A GB 1309669 A GB1309669 A GB 1309669A GB 4294770 A GB4294770 A GB 4294770A GB 4294770 A GB4294770 A GB 4294770A GB 1309669 A GB1309669 A GB 1309669A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- methyl
- compound
- group
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- OJMMVQQUTAEWLP-KIDUDLJLSA-N lincomycin Chemical class CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@@H](C)O)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 OJMMVQQUTAEWLP-KIDUDLJLSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- WQZGKKKJIJFFOK-SVZMEOIVSA-N (+)-Galactose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-SVZMEOIVSA-N 0.000 abstract 2
- OJMMVQQUTAEWLP-UHFFFAOYSA-N Lincomycin Natural products CN1CC(CCC)CC1C(=O)NC(C(C)O)C1C(O)C(O)C(O)C(SC)O1 OJMMVQQUTAEWLP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- -1 hydroxy- Chemical class 0.000 abstract 2
- KBPUJKKGFLKUIA-XLSKCSLXSA-N (2R,3S,4S,5R)-6-methoxy-6-methylsulfanylhexane-1,2,3,4,5-pentol Chemical compound COC([C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO)SC KBPUJKKGFLKUIA-XLSKCSLXSA-N 0.000 abstract 1
- LZFNFLTVAMOOPJ-VOQCIKJUSA-N (2r,3r,4s,5r,6r)-2-(hydroxymethyl)-6-methylsulfanyloxane-3,4,5-triol Chemical compound CS[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O LZFNFLTVAMOOPJ-VOQCIKJUSA-N 0.000 abstract 1
- 229910010082 LiAlH Inorganic materials 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000006501 nitrophenyl group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003944 tolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
- C07H15/16—Lincomycin; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86736269A | 1969-10-17 | 1969-10-17 | |
| US3525670A | 1970-05-06 | 1970-05-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1309669A true GB1309669A (en) | 1973-03-14 |
Family
ID=26711937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4294770A Expired GB1309669A (en) | 1969-10-17 | 1970-09-08 | Lincomycin derivatives and the manufacture thereof |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS4936686B1 (enExample) |
| BE (1) | BE757611A (enExample) |
| CA (1) | CA919663A (enExample) |
| CH (1) | CH570419A5 (enExample) |
| DE (1) | DE2050549A1 (enExample) |
| FR (1) | FR2070143B1 (enExample) |
| GB (1) | GB1309669A (enExample) |
| IL (1) | IL35256A (enExample) |
| NL (1) | NL7015046A (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110606865A (zh) * | 2018-06-14 | 2019-12-24 | 天津科伦药物研究有限公司 | 盐酸克林霉素杂质的制备方法 |
-
0
- BE BE757611D patent/BE757611A/xx unknown
-
1970
- 1970-09-08 GB GB4294770A patent/GB1309669A/en not_active Expired
- 1970-09-08 IL IL35256A patent/IL35256A/xx unknown
- 1970-09-17 CA CA093400A patent/CA919663A/en not_active Expired
- 1970-09-28 CH CH1432570A patent/CH570419A5/xx not_active IP Right Cessation
- 1970-10-12 JP JP45088893A patent/JPS4936686B1/ja active Pending
- 1970-10-14 NL NL7015046A patent/NL7015046A/xx unknown
- 1970-10-15 DE DE19702050549 patent/DE2050549A1/de active Pending
- 1970-10-16 FR FR7037499A patent/FR2070143B1/fr not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110606865A (zh) * | 2018-06-14 | 2019-12-24 | 天津科伦药物研究有限公司 | 盐酸克林霉素杂质的制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CH570419A5 (enExample) | 1975-12-15 |
| BE757611A (fr) | 1971-04-16 |
| IL35256A0 (en) | 1970-11-30 |
| FR2070143A1 (enExample) | 1971-09-10 |
| IL35256A (en) | 1974-01-14 |
| CA919663A (en) | 1973-01-23 |
| DE2050549A1 (de) | 1971-04-29 |
| JPS4936686B1 (enExample) | 1974-10-02 |
| NL7015046A (enExample) | 1971-04-20 |
| FR2070143B1 (enExample) | 1974-08-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |