GB1307341A - 5-azaspiro-2,4-heptane-4,6-diones - Google Patents
5-azaspiro-2,4-heptane-4,6-dionesInfo
- Publication number
- GB1307341A GB1307341A GB149771A GB149771A GB1307341A GB 1307341 A GB1307341 A GB 1307341A GB 149771 A GB149771 A GB 149771A GB 149771 A GB149771 A GB 149771A GB 1307341 A GB1307341 A GB 1307341A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phenyl
- alkyl
- chart
- diones
- azaspiro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 241000287433 Turdus Species 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005059 halophenyl group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- -1 trifluoromethyl-phenyl Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
- C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
- C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/54—Spiro-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US590470A | 1970-01-26 | 1970-01-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1307341A true GB1307341A (en) | 1973-02-21 |
Family
ID=21718290
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB149771A Expired GB1307341A (en) | 1970-01-26 | 1971-01-12 | 5-azaspiro-2,4-heptane-4,6-diones |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US3654306A (enExample) |
| AU (1) | AU2455471A (enExample) |
| CA (1) | CA942753A (enExample) |
| CH (1) | CH547798A (enExample) |
| DE (1) | DE2103576A1 (enExample) |
| ES (1) | ES386409A1 (enExample) |
| FR (1) | FR2081459B1 (enExample) |
| GB (1) | GB1307341A (enExample) |
| ZA (1) | ZA71471B (enExample) |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8524717B2 (en) | 2008-10-17 | 2013-09-03 | Oryzon Genomics, S.A. | Oxidase inhibitors and their use |
| US8722743B2 (en) | 2010-04-19 | 2014-05-13 | Oryzon Genomics S.A. | Lysine specific demethylase-1 inhibitors and their use |
| US8859555B2 (en) | 2009-09-25 | 2014-10-14 | Oryzon Genomics S.A. | Lysine Specific Demethylase-1 inhibitors and their use |
| US8946296B2 (en) | 2009-10-09 | 2015-02-03 | Oryzon Genomics S.A. | Substituted heteroaryl- and aryl-cyclopropylamine acetamides and their use |
| US8993808B2 (en) | 2009-01-21 | 2015-03-31 | Oryzon Genomics, S.A. | Phenylcyclopropylamine derivatives and their medical use |
| US9006449B2 (en) | 2010-07-29 | 2015-04-14 | Oryzon Genomics, S.A. | Cyclopropylamine derivatives useful as LSD1 inhibitors |
| US9061966B2 (en) | 2010-10-08 | 2015-06-23 | Oryzon Genomics S.A. | Cyclopropylamine inhibitors of oxidases |
| US9181198B2 (en) | 2010-07-29 | 2015-11-10 | Oryzon Genomics S.A. | Arylcyclopropylamine based demethylase inhibitors of LSD1 and their medical use |
| US9186337B2 (en) | 2010-02-24 | 2015-11-17 | Oryzon Genomics S.A. | Lysine demethylase inhibitors for diseases and disorders associated with Hepadnaviridae |
| US9469597B2 (en) | 2011-10-20 | 2016-10-18 | Oryzon Genomics S.A. | (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors |
| US9487512B2 (en) | 2011-10-20 | 2016-11-08 | Oryzon Genomics S.A. | (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors |
| US9616058B2 (en) | 2010-02-24 | 2017-04-11 | Oryzon Genomics, S.A. | Potent selective LSD1 inhibitors and dual LSD1/MAO-B inhibitors for antiviral use |
| US9790196B2 (en) | 2010-11-30 | 2017-10-17 | Oryzon Genomics S.A. | Lysine demethylase inhibitors for diseases and disorders associated with Flaviviridae |
| US9908859B2 (en) | 2011-02-08 | 2018-03-06 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for myeloproliferative disorders |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5398959A (en) * | 1977-02-07 | 1978-08-29 | Sumitomo Chem Co Ltd | Cycloalkanespiro-3- 1-(3,5-dihalogenophenyl) pyrrolidine-2,5-dione process for their preparation and nonmedical fungicides containing the same as active constituents |
| FR2476075A1 (fr) * | 1980-02-18 | 1981-08-21 | Rhone Poulenc Agrochimie | Nouveaux derives de l'acide methylene-2 succinamique, leur preparation et les compositions regulatrices de la croissance des plantes les contenant |
| EP1289960A2 (en) * | 2000-06-15 | 2003-03-12 | Pharmacia Corporation | Cycloalkyl alkanoic acids as integrin receptor antagonists |
| US20040043988A1 (en) * | 2001-06-15 | 2004-03-04 | Khanna Ish Kurmar | Cycloalkyl alkanoic acids as intergrin receptor antagonists |
-
1970
- 1970-01-26 US US5904A patent/US3654306A/en not_active Expired - Lifetime
- 1970-12-12 ES ES386409A patent/ES386409A1/es not_active Expired
-
1971
- 1971-01-12 GB GB149771A patent/GB1307341A/en not_active Expired
- 1971-01-19 CA CA103,115A patent/CA942753A/en not_active Expired
- 1971-01-21 AU AU24554/71A patent/AU2455471A/en not_active Expired
- 1971-01-25 CH CH107871A patent/CH547798A/fr not_active IP Right Cessation
- 1971-01-25 FR FR717102365A patent/FR2081459B1/fr not_active Expired
- 1971-01-25 ZA ZA710471A patent/ZA71471B/xx unknown
- 1971-01-26 DE DE19712103576 patent/DE2103576A1/de active Pending
Cited By (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8524717B2 (en) | 2008-10-17 | 2013-09-03 | Oryzon Genomics, S.A. | Oxidase inhibitors and their use |
| US8993808B2 (en) | 2009-01-21 | 2015-03-31 | Oryzon Genomics, S.A. | Phenylcyclopropylamine derivatives and their medical use |
| US8859555B2 (en) | 2009-09-25 | 2014-10-14 | Oryzon Genomics S.A. | Lysine Specific Demethylase-1 inhibitors and their use |
| US8946296B2 (en) | 2009-10-09 | 2015-02-03 | Oryzon Genomics S.A. | Substituted heteroaryl- and aryl-cyclopropylamine acetamides and their use |
| US9186337B2 (en) | 2010-02-24 | 2015-11-17 | Oryzon Genomics S.A. | Lysine demethylase inhibitors for diseases and disorders associated with Hepadnaviridae |
| US9616058B2 (en) | 2010-02-24 | 2017-04-11 | Oryzon Genomics, S.A. | Potent selective LSD1 inhibitors and dual LSD1/MAO-B inhibitors for antiviral use |
| US8722743B2 (en) | 2010-04-19 | 2014-05-13 | Oryzon Genomics S.A. | Lysine specific demethylase-1 inhibitors and their use |
| US10202330B2 (en) | 2010-04-19 | 2019-02-12 | Oryzon Genomics, Sa | Lysine specific demethylase-1 inhibitors and their use |
| US9149447B2 (en) | 2010-04-19 | 2015-10-06 | Oryzon Genomics S.A. | Lysine specific demethylase-1 inhibitors and their use |
| US9708309B2 (en) | 2010-07-29 | 2017-07-18 | Oryzon Genomics, S.A. | Arylcyclopropylamine based demethylase inhibitors of LSD1 and their medical use |
| US10233178B2 (en) | 2010-07-29 | 2019-03-19 | Oryzon Genomics, S.A. | Arylcyclopropylamine based demethylase inhibitors of LSD1 and their medical use |
| US9181198B2 (en) | 2010-07-29 | 2015-11-10 | Oryzon Genomics S.A. | Arylcyclopropylamine based demethylase inhibitors of LSD1 and their medical use |
| US9006449B2 (en) | 2010-07-29 | 2015-04-14 | Oryzon Genomics, S.A. | Cyclopropylamine derivatives useful as LSD1 inhibitors |
| US9676701B2 (en) | 2010-07-29 | 2017-06-13 | Oryzon Genomics, S.A. | Cyclopropylamine derivatives useful as LSD1 inhibitors |
| US9061966B2 (en) | 2010-10-08 | 2015-06-23 | Oryzon Genomics S.A. | Cyclopropylamine inhibitors of oxidases |
| US9790196B2 (en) | 2010-11-30 | 2017-10-17 | Oryzon Genomics S.A. | Lysine demethylase inhibitors for diseases and disorders associated with Flaviviridae |
| US9908859B2 (en) | 2011-02-08 | 2018-03-06 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for myeloproliferative disorders |
| US9469597B2 (en) | 2011-10-20 | 2016-10-18 | Oryzon Genomics S.A. | (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors |
| US9944601B2 (en) | 2011-10-20 | 2018-04-17 | Oryzon Genomics, S.A. | (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors |
| US9670136B2 (en) | 2011-10-20 | 2017-06-06 | Oryzon Genomics S.A. | (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors |
| US10214477B2 (en) | 2011-10-20 | 2019-02-26 | Oryzon Genomics S.A. | (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors |
| US9487512B2 (en) | 2011-10-20 | 2016-11-08 | Oryzon Genomics S.A. | (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors |
| US10329256B2 (en) | 2011-10-20 | 2019-06-25 | Oryzon Genomics, S.A. | (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2455471A (en) | 1972-07-27 |
| FR2081459B1 (enExample) | 1974-02-15 |
| CH547798A (fr) | 1974-04-11 |
| CA942753A (en) | 1974-02-26 |
| ES386409A1 (es) | 1973-12-01 |
| US3654306A (en) | 1972-04-04 |
| ZA71471B (en) | 1971-11-24 |
| DE2103576A1 (de) | 1971-08-26 |
| FR2081459A1 (enExample) | 1971-12-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |