GB1307277A - 1-carbamoyl-4-phenylpiperidines and tetrahydropyridines - Google Patents
1-carbamoyl-4-phenylpiperidines and tetrahydropyridinesInfo
- Publication number
- GB1307277A GB1307277A GB5050970A GB5050970A GB1307277A GB 1307277 A GB1307277 A GB 1307277A GB 5050970 A GB5050970 A GB 5050970A GB 5050970 A GB5050970 A GB 5050970A GB 1307277 A GB1307277 A GB 1307277A
- Authority
- GB
- United Kingdom
- Prior art keywords
- trifluoromethylphenyl
- formula
- tetrahydropyridine
- piperidine
- oct
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- FZOKXDNYTHYNPE-UHFFFAOYSA-N 4-phenylpiperidine-1-carboxamide Chemical class C1CN(C(=O)N)CCC1C1=CC=CC=C1 FZOKXDNYTHYNPE-UHFFFAOYSA-N 0.000 title 1
- 125000004853 tetrahydropyridinyl group Chemical class N1(CCCC=C1)* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- -1 1 - Carbamoyl - 4 - trifluoromethylphenyl hydrogenated pyridines Chemical class 0.000 abstract 1
- IFYKRMQORZOMNY-UHFFFAOYSA-N 4-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine Chemical compound FC(F)(F)C1=CC=CC(C=2CCNCC=2)=C1 IFYKRMQORZOMNY-UHFFFAOYSA-N 0.000 abstract 1
- RJFISGALWPADNA-UHFFFAOYSA-N 4-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine;hydrochloride Chemical compound Cl.FC(F)(F)C1=CC=CC(C=2CCNCC=2)=C1 RJFISGALWPADNA-UHFFFAOYSA-N 0.000 abstract 1
- SBKPKQORDCJPSQ-UHFFFAOYSA-N 4-[3-(trifluoromethyl)phenyl]piperidin-4-ol;hydrochloride Chemical compound Cl.C=1C=CC(C(F)(F)F)=CC=1C1(O)CCNCC1 SBKPKQORDCJPSQ-UHFFFAOYSA-N 0.000 abstract 1
- IPKSNWXGEIHOMR-UHFFFAOYSA-N 4-[3-(trifluoromethyl)phenyl]piperidine Chemical compound FC(F)(F)C1=CC=CC(C2CCNCC2)=C1 IPKSNWXGEIHOMR-UHFFFAOYSA-N 0.000 abstract 1
- AKGAUMQWPLQYHW-UHFFFAOYSA-N 4-[4-(trifluoromethyl)phenyl]piperidine Chemical compound C1=CC(C(F)(F)F)=CC=C1C1CCNCC1 AKGAUMQWPLQYHW-UHFFFAOYSA-N 0.000 abstract 1
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 1
- 241000287433 Turdus Species 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000001773 anti-convulsant effect Effects 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 229960003965 antiepileptics Drugs 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000012948 isocyanate Substances 0.000 abstract 1
- 150000002513 isocyanates Chemical class 0.000 abstract 1
- 239000003158 myorelaxant agent Substances 0.000 abstract 1
- CMUOJBJRZUHRMU-UHFFFAOYSA-N nitrourea Chemical compound NC(=O)N[N+]([O-])=O CMUOJBJRZUHRMU-UHFFFAOYSA-N 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 230000002040 relaxant effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/02—Preparation by ring-closure or hydrogenation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86988169A | 1969-10-27 | 1969-10-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1307277A true GB1307277A (en) | 1973-02-14 |
Family
ID=25354406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5050970A Expired GB1307277A (en) | 1969-10-27 | 1970-10-23 | 1-carbamoyl-4-phenylpiperidines and tetrahydropyridines |
Country Status (14)
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4357471A (en) | 1976-12-17 | 1982-11-02 | Rohm And Haas Company | Azaspiro compounds |
| US4374991A (en) | 1976-12-17 | 1983-02-22 | Rohm And Haas Company | 2,6-Dimethylpiperidinyl-N-carbobutoxymethyl urea |
| US4400512A (en) * | 1976-12-17 | 1983-08-23 | Rohm And Haas Company | Azaspiro compounds |
| US4405630A (en) * | 1980-12-29 | 1983-09-20 | Rohm And Haas Company | Arthropod repellent compositions and methods |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2501506A1 (fr) * | 1981-03-11 | 1982-09-17 | Sanofi Sa | Compositions pharmaceutiques a action anorexigene contenant des derives de la tetrahydropyridine |
| EP2080757A1 (en) * | 2003-07-24 | 2009-07-22 | Euro-Celtique S.A. | Heteroaryl-tetrahydropiperidyl compounds useful for treating or preventing pain |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1087174A (en) * | 1965-04-05 | 1967-10-11 | Allen & Hanburys Ltd | Piperidine derivatives |
| FR1589754A (enrdf_load_stackoverflow) * | 1968-10-17 | 1970-04-06 |
-
0
- BE BE757436D patent/BE757436A/xx unknown
-
1970
- 1970-10-02 DE DE19702048589 patent/DE2048589A1/de active Pending
- 1970-10-07 ES ES384311A patent/ES384311A1/es not_active Expired
- 1970-10-15 SE SE7013959A patent/SE372942B/xx unknown
- 1970-10-15 SE SE7312890A patent/SE382454B/xx unknown
- 1970-10-20 CH CH1546970A patent/CH525886A/fr not_active IP Right Cessation
- 1970-10-21 NL NL7015396A patent/NL7015396A/xx unknown
- 1970-10-22 PH PH11886*UA patent/PH9289A/en unknown
- 1970-10-23 GB GB5050970A patent/GB1307277A/en not_active Expired
- 1970-10-26 CA CA096580A patent/CA918161A/en not_active Expired
- 1970-10-26 FR FR7038570A patent/FR2070167B1/fr not_active Expired
- 1970-10-26 NO NO4046/70A patent/NO131172C/no unknown
- 1970-10-27 ZA ZA707307A patent/ZA707307B/xx unknown
- 1970-10-27 AT AT966570A patent/AT302354B/de not_active IP Right Cessation
- 1970-10-27 JP JP45094014A patent/JPS4939266B1/ja active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4357471A (en) | 1976-12-17 | 1982-11-02 | Rohm And Haas Company | Azaspiro compounds |
| US4374991A (en) | 1976-12-17 | 1983-02-22 | Rohm And Haas Company | 2,6-Dimethylpiperidinyl-N-carbobutoxymethyl urea |
| US4400512A (en) * | 1976-12-17 | 1983-08-23 | Rohm And Haas Company | Azaspiro compounds |
| US4405630A (en) * | 1980-12-29 | 1983-09-20 | Rohm And Haas Company | Arthropod repellent compositions and methods |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2070167A1 (enrdf_load_stackoverflow) | 1971-09-10 |
| PH9289A (en) | 1975-08-13 |
| DE2048589A1 (de) | 1971-05-06 |
| ZA707307B (en) | 1971-07-28 |
| NO131172C (enrdf_load_stackoverflow) | 1975-04-16 |
| CH525886A (fr) | 1972-07-31 |
| NL7015396A (enrdf_load_stackoverflow) | 1971-04-29 |
| ES384311A1 (es) | 1973-09-01 |
| SE382454B (sv) | 1976-02-02 |
| FR2070167B1 (enrdf_load_stackoverflow) | 1975-03-14 |
| NO131172B (enrdf_load_stackoverflow) | 1975-01-06 |
| AT302354B (de) | 1972-10-10 |
| CA918161A (en) | 1973-01-02 |
| BE757436A (fr) | 1971-03-16 |
| JPS4939266B1 (enrdf_load_stackoverflow) | 1974-10-24 |
| SE372942B (enrdf_load_stackoverflow) | 1975-01-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |