GB1306819A - Derivatives of the kallikrein-trypsin inhibitor their preparation and their use - Google Patents
Derivatives of the kallikrein-trypsin inhibitor their preparation and their useInfo
- Publication number
- GB1306819A GB1306819A GB6025570A GB6025570A GB1306819A GB 1306819 A GB1306819 A GB 1306819A GB 6025570 A GB6025570 A GB 6025570A GB 6025570 A GB6025570 A GB 6025570A GB 1306819 A GB1306819 A GB 1306819A
- Authority
- GB
- United Kingdom
- Prior art keywords
- kti
- kallikrein
- derivatives
- trypsin inhibitor
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
1306819 Acyl derivatives of kallikrein-trypsin inhibitor BAYER AG 18 Dec 1970 [19 Dec 1969] 60255/70 Heading C3H Acyl derivatives of kallikrein-trypsin inhibitor (KTI) have at least one amino group selected from the #-amino groups of the lysine residues at the 26, 41 and 46-positions and the amino group of the N-terminal arginine residue acylated, but the reactive centre of the KTI remains unacylated. Such derivatives may be prepared by blocking the reactive centre with an enzyme, e.g. trypsin, then acylating the blocked KTI, and finally decomposing the complex to obtain the acylated KTI. Many acylating agents are listed.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19691963733 DE1963733A1 (en) | 1969-12-19 | 1969-12-19 | Acyl derivatives of the KTI |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1306819A true GB1306819A (en) | 1973-02-14 |
Family
ID=5754389
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB6025570A Expired GB1306819A (en) | 1969-12-19 | 1970-12-18 | Derivatives of the kallikrein-trypsin inhibitor their preparation and their use |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS4821938B1 (en) |
| AT (1) | AT300187B (en) |
| BE (1) | BE760540A (en) |
| CA (1) | CA923493A (en) |
| CH (1) | CH546796A (en) |
| DE (1) | DE1963733A1 (en) |
| ES (1) | ES386644A1 (en) |
| FI (1) | FI47891C (en) |
| FR (1) | FR2081386B1 (en) |
| GB (1) | GB1306819A (en) |
| IL (1) | IL35726A (en) |
| NL (1) | NL7018351A (en) |
| NO (1) | NO130481C (en) |
| ZA (1) | ZA708057B (en) |
-
1969
- 1969-12-19 DE DE19691963733 patent/DE1963733A1/en active Pending
-
1970
- 1970-11-24 CA CA098944A patent/CA923493A/en not_active Expired
- 1970-11-25 CH CH1743370A patent/CH546796A/en not_active IP Right Cessation
- 1970-11-25 IL IL35726A patent/IL35726A/en unknown
- 1970-11-27 ZA ZA708057A patent/ZA708057B/en unknown
- 1970-12-07 FI FI703284A patent/FI47891C/en active
- 1970-12-15 AT AT1126370A patent/AT300187B/en active
- 1970-12-15 NO NO4817/70A patent/NO130481C/no unknown
- 1970-12-16 NL NL7018351A patent/NL7018351A/xx unknown
- 1970-12-16 JP JP45111942A patent/JPS4821938B1/ja active Pending
- 1970-12-18 FR FR707045891A patent/FR2081386B1/fr not_active Expired
- 1970-12-18 BE BE760540A patent/BE760540A/en unknown
- 1970-12-18 GB GB6025570A patent/GB1306819A/en not_active Expired
- 1970-12-19 ES ES386644A patent/ES386644A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES386644A1 (en) | 1973-03-16 |
| CH546796A (en) | 1974-03-15 |
| JPS4821938B1 (en) | 1973-07-02 |
| FR2081386A1 (en) | 1971-12-03 |
| IL35726A0 (en) | 1971-01-28 |
| NO130481C (en) | 1974-12-18 |
| NO130481B (en) | 1974-09-09 |
| NL7018351A (en) | 1971-06-22 |
| ZA708057B (en) | 1971-08-25 |
| FR2081386B1 (en) | 1974-06-21 |
| BE760540A (en) | 1971-06-18 |
| FI47891C (en) | 1974-04-10 |
| DE1963733A1 (en) | 1971-06-24 |
| FI47891B (en) | 1974-01-02 |
| IL35726A (en) | 1974-01-14 |
| CA923493A (en) | 1973-03-27 |
| AT300187B (en) | 1972-07-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |