GB1304664A - - Google Patents
Info
- Publication number
- GB1304664A GB1304664A GB2532471*A GB2532471A GB1304664A GB 1304664 A GB1304664 A GB 1304664A GB 2532471 A GB2532471 A GB 2532471A GB 1304664 A GB1304664 A GB 1304664A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- carboxy
- prepared
- group
- chloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
1304664 Aryl bicyclo[2,2.2]-octanecarboxylates DAIICHI SEIYAKU CO Ltd 19 April 1971 [25 March 1970] 25324/71 Heading C2C Novel compounds of Formula I wherein R is H, carboxy, #-carboxyalkyl, #-carboxyalkenyl, #-carboxyalkylcarbonyl, #-carboxyalkoxy or #-carboxyaminoalkyl in which the alkyl group has 1 to 6 carbon atoms, and R<SP>1</SP> is H or optionally carboxy when R is 4<SP>1</SP>-carboxy and mineral acid salts thereof, are prepared by removal of protecting groups from an intermediate of Formula V wherein -COOZ is a protective group, R<SP>11</SP> is the same as R or is a group R in which the terminal carboxy group is protected and R<SP>111</SP> is the same as R<SP>1</SP> or is a protected carboxy group, which is prepared by reaction of a phenol of Formula IV with a compound of formula wherein X is halogen. Intermediates of Formula IV above are prepared from the free acid and benzyl chloride. N-Benzyloxycarbonylaminomethylbicyclo- [2,2,2] - octane - 1 - carboxylic acid chloride is prepared by action of thionyl chloride on the carboxylic acid which is obtained by action of benzyloxycarbonyl chloride on the sodium salt of the amino-acid and acidification. Pharmaceutical compositions having antithrombin activity comprise an above novel compound and a pharmaceutical carrier.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP45025130A JPS4910951B1 (en) | 1970-03-25 | 1970-03-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1304664A true GB1304664A (en) | 1973-01-24 |
Family
ID=12157357
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2532471*A Expired GB1304664A (en) | 1970-03-25 | 1971-04-19 |
Country Status (4)
Country | Link |
---|---|
JP (1) | JPS4910951B1 (en) |
DE (1) | DE2114573C3 (en) |
FR (1) | FR2085743B1 (en) |
GB (1) | GB1304664A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2168974A (en) * | 1984-12-20 | 1986-07-02 | Procter & Gamble | Compounds and compositions having anti-inflammatory activity |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020176496A1 (en) | 2019-02-26 | 2020-09-03 | Maat Energy Company | Device and method for improving specific energy requirement of plasma pyrolyzing or reforming systems |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL31192A (en) * | 1967-12-14 | 1972-03-28 | Merck & Co Inc | Anti-fibrinolytic bicycloheptane,bicyclooctane and bicyclononane compounds |
-
1970
- 1970-03-25 JP JP45025130A patent/JPS4910951B1/ja active Pending
-
1971
- 1971-03-25 DE DE2114573A patent/DE2114573C3/en not_active Expired
- 1971-03-25 FR FR7110658A patent/FR2085743B1/fr not_active Expired
- 1971-04-19 GB GB2532471*A patent/GB1304664A/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2168974A (en) * | 1984-12-20 | 1986-07-02 | Procter & Gamble | Compounds and compositions having anti-inflammatory activity |
Also Published As
Publication number | Publication date |
---|---|
FR2085743B1 (en) | 1974-11-15 |
DE2114573A1 (en) | 1971-10-07 |
JPS4910951B1 (en) | 1974-03-13 |
DE2114573C3 (en) | 1982-04-22 |
FR2085743A1 (en) | 1971-12-31 |
DE2114573B2 (en) | 1981-07-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed |