GB1304645A - - Google Patents
Info
- Publication number
- GB1304645A GB1304645A GB3218771A GB3218771A GB1304645A GB 1304645 A GB1304645 A GB 1304645A GB 3218771 A GB3218771 A GB 3218771A GB 3218771 A GB3218771 A GB 3218771A GB 1304645 A GB1304645 A GB 1304645A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- substituted
- dioxolan
- july
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1304645 Substituted indoles ROUSSEL UCLAF 8 July 1971 [8 July 1970] 32187/71 Heading C2C The invention comprises compounds of formula wherein Y, Z are each H, halogen, C 1-6 alkoxy, di(C 1-6 -alkyl)amino, C 1-5 alkyl, NO 2 , CF 3 , C 1-6 alkylthio (possibly aryl-substituted), or C 1-6 alkylsulphonyl; Ar, which is optionally substituted, is cyclohexyl or a homocyclic or heterocyclic aromatic group; A is CHR<SP>1</SP> (where R<SP>1</SP> is H or C 1-6 alkyl; and R, R<SP>1</SP> are either both H(Ia), or together form a di(C 1-6 -alkyl)methylene group (Ib). Ia are prepared by acid hydrolysis of Ib; Ib are prepared by reacting (i) under basic conditions, a 1-unsubstituted indole with a 4 - (haloalkanoyloxymethyl) - 1,3 - dioxolan, or (ii) a 1-alkoxycarbonylalkyl-indole with a 4-hydroxymethyl -1,3 -dioxolan. Therapeutic compositions for oral, parenteral, permucous rectal or topical administration comprise compounds of the above formula, which have analgesic and anti-inflammatory properties. Besides a carrier or excipient, there may be present a spasmolytic, hypnotic, anticoagulant or agent improving diffusion in the organism and/or penetration of the tissues of the above compounds.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7025316A FR2096868B1 (en) | 1970-07-08 | 1970-07-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1304645A true GB1304645A (en) | 1973-01-24 |
Family
ID=9058455
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3218771A Expired GB1304645A (en) | 1970-07-08 | 1971-07-08 |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS5617351B1 (en) |
| AT (1) | AT306000B (en) |
| BE (1) | BE769613A (en) |
| CA (1) | CA933930A (en) |
| CH (2) | CH545314A (en) |
| DE (1) | DE2133082C3 (en) |
| DK (1) | DK137532B (en) |
| ES (2) | ES393005A1 (en) |
| FR (1) | FR2096868B1 (en) |
| GB (1) | GB1304645A (en) |
| IL (1) | IL36964A (en) |
| LU (1) | LU63486A1 (en) |
| NL (1) | NL7109431A (en) |
| OA (1) | OA03897A (en) |
| SE (1) | SE376766B (en) |
| SU (2) | SU498904A3 (en) |
| ZA (1) | ZA714322B (en) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1492929A (en) * | 1966-05-11 | 1967-08-25 | Roussel Uclaf | Novel substituted 1- (omega-carboxyalkyl) indoles and method of preparation |
| FR7337M (en) * | 1968-01-11 | 1969-10-13 | ||
| US3557142A (en) * | 1968-02-20 | 1971-01-19 | Sterling Drug Inc | 4,5,6,7-tetrahydro-indole-lower-alkanoic acids and esters |
-
1970
- 1970-07-08 FR FR7025316A patent/FR2096868B1/fr not_active Expired
-
1971
- 1971-06-02 IL IL36964A patent/IL36964A/en unknown
- 1971-06-23 CH CH1074773A patent/CH545314A/en not_active IP Right Cessation
- 1971-06-23 CH CH918171A patent/CH544111A/en not_active IP Right Cessation
- 1971-06-30 SU SU1670143A patent/SU498904A3/en active
- 1971-06-30 OA OA54289A patent/OA03897A/en unknown
- 1971-07-01 ZA ZA714322A patent/ZA714322B/en unknown
- 1971-07-02 DE DE2133082A patent/DE2133082C3/en not_active Expired
- 1971-07-07 ES ES393005A patent/ES393005A1/en not_active Expired
- 1971-07-07 SE SE7108807A patent/SE376766B/xx unknown
- 1971-07-07 CA CA117686A patent/CA933930A/en not_active Expired
- 1971-07-07 BE BE769613A patent/BE769613A/en unknown
- 1971-07-07 DK DK334271AA patent/DK137532B/en unknown
- 1971-07-07 ES ES393006A patent/ES393006A1/en not_active Expired
- 1971-07-07 AT AT590771A patent/AT306000B/en not_active IP Right Cessation
- 1971-07-07 LU LU63486D patent/LU63486A1/xx unknown
- 1971-07-08 GB GB3218771A patent/GB1304645A/en not_active Expired
- 1971-07-08 NL NL7109431A patent/NL7109431A/xx not_active Application Discontinuation
- 1971-07-08 JP JP4998171A patent/JPS5617351B1/ja active Pending
-
1974
- 1974-01-31 SU SU1993666A patent/SU526287A3/en active
Also Published As
| Publication number | Publication date |
|---|---|
| SE376766B (en) | 1975-06-09 |
| IL36964A0 (en) | 1971-08-25 |
| NL7109431A (en) | 1972-01-11 |
| JPS5617351B1 (en) | 1981-04-22 |
| AT306000B (en) | 1973-03-26 |
| SU526287A3 (en) | 1976-08-25 |
| DK137532B (en) | 1978-03-20 |
| CA933930A (en) | 1973-09-18 |
| ES393005A1 (en) | 1973-08-01 |
| DK137532C (en) | 1978-09-04 |
| ZA714322B (en) | 1972-08-30 |
| CH545314A (en) | 1974-01-31 |
| DE2133082C3 (en) | 1979-04-19 |
| FR2096868A1 (en) | 1972-03-03 |
| BE769613A (en) | 1972-01-07 |
| DE2133082A1 (en) | 1972-01-13 |
| LU63486A1 (en) | 1971-11-15 |
| SU498904A3 (en) | 1976-01-05 |
| FR2096868B1 (en) | 1974-02-01 |
| ES393006A1 (en) | 1973-08-01 |
| IL36964A (en) | 1974-10-22 |
| CH544111A (en) | 1973-11-15 |
| OA03897A (en) | 1975-08-14 |
| DE2133082B2 (en) | 1978-08-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |