GB1303638A - - Google Patents

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Publication number
GB1303638A
GB1303638A GB1303638DA GB1303638A GB 1303638 A GB1303638 A GB 1303638A GB 1303638D A GB1303638D A GB 1303638DA GB 1303638 A GB1303638 A GB 1303638A
Authority
GB
United Kingdom
Prior art keywords
pregn
acetoxy
hydroxy
give
pregna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GB1303638A publication Critical patent/GB1303638A/en
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

1303638 17α - Hydroxy - 5α - pregn - 9(11)- ene-3,20-dione GLAXO LABORATORIES Ltd 29 May [970 [30 May 1969] 27603/69 Heading C2U The novel title steroid is prepared by hydrogenating 3# - acetoxy - 5α - pregna - 9,16- dien - 20 - one to give 3# - acetoxy - 5α- pregn - 9 - en - 20 - one, reacting this or the corresponding 3#-ol in the form of an enolate thereof with molecular oxygen to give 3#- (hydroxy and/or acetoxy) - 17α - hydroperoxy - 5α - pregn - 9 - en - 20 - one, reducing to give 3#,17α - dihydroxy - 5α - pregn - 9- en-20-one, with hydrolysis of any 3-acetate when required, and oxidizing this: and is converted to 17α-hydroxy-pregna-1,4,9(11)-triene-3,20-dione by direct dehydrogenation or indirectly via the corresponding 2,4-dibromo compound.
GB1303638D 1969-05-30 1969-05-30 Expired GB1303638A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2760369 1969-05-30

Publications (1)

Publication Number Publication Date
GB1303638A true GB1303638A (en) 1973-01-17

Family

ID=10262316

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1303638D Expired GB1303638A (en) 1969-05-30 1969-05-30

Country Status (4)

Country Link
DE (1) DE2026392A1 (en)
FR (1) FR2054559B1 (en)
GB (1) GB1303638A (en)
NL (1) NL7007797A (en)

Also Published As

Publication number Publication date
FR2054559A1 (en) 1971-04-23
FR2054559B1 (en) 1973-04-06
NL7007797A (en) 1970-12-02
DE2026392A1 (en) 1970-12-23

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees