GB1302322A - - Google Patents

Info

Publication number
GB1302322A
GB1302322A GB1329671*[A GB1329671A GB1302322A GB 1302322 A GB1302322 A GB 1302322A GB 1329671 A GB1329671 A GB 1329671A GB 1302322 A GB1302322 A GB 1302322A
Authority
GB
United Kingdom
Prior art keywords
inorganic salt
salt content
venom
solutions
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1329671*[A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GB1302322A publication Critical patent/GB1302322A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6418—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals from snakes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

1302322 Anti-coagulant isolation ABBOTT LABORATORIES 5 May 1971 [1 June 1970] 13296/71 Heading ASB Biologically pure solutions of the thrombinlike material obtained from pit viper venom having anticoagulant activity are prepared by placing an aqueous solution containing 5-20% weight/volume of native venom buffered to a pH of 7.0 Π1.0 and containing from 0.15 to 0.5 molarity of total inorganic salt content on a column packed with a molecular sieve such as a partially cross-linked dextran gel or a polyacrylamide gel, eluting said column with an aqueous solution containing the same type and amount of inorganic salt content as the venom solution in small fractions and pooling the fractions which contain thrombin-like activity. The inorganic salt content preferably comprises equal molar proportions of sodium chloride and sodium phosphate. Injectable solutions are prepared from the above obtained solutions of the thrombin-like material.
GB1329671*[A 1970-06-01 1971-05-05 Expired GB1302322A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4259670A 1970-06-01 1970-06-01

Publications (1)

Publication Number Publication Date
GB1302322A true GB1302322A (en) 1973-01-10

Family

ID=21922772

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1329671*[A Expired GB1302322A (en) 1970-06-01 1971-05-05

Country Status (6)

Country Link
JP (1) JPS5414163B1 (en)
CA (1) CA953212A (en)
DE (1) DE2126713A1 (en)
FR (1) FR2104751B1 (en)
GB (1) GB1302322A (en)
ZA (1) ZA712888B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101797377B (en) * 2009-02-11 2012-01-25 北京赛升药业股份有限公司 Fibrin sealant and preparation method thereof

Also Published As

Publication number Publication date
DE2126713A1 (en) 1971-12-09
FR2104751B1 (en) 1975-10-31
CA953212A (en) 1974-08-20
JPS5414163B1 (en) 1979-06-05
ZA712888B (en) 1972-01-26
FR2104751A1 (en) 1972-04-21

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee