GB1301254A - - Google Patents
Info
- Publication number
- GB1301254A GB1301254A GB1301254DA GB1301254A GB 1301254 A GB1301254 A GB 1301254A GB 1301254D A GB1301254D A GB 1301254DA GB 1301254 A GB1301254 A GB 1301254A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phch
- compounds
- piperidine
- oxo
- gastric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- VRJHQPZVIGNGMX-UHFFFAOYSA-N 4-piperidinone Chemical compound O=C1CCNCC1 VRJHQPZVIGNGMX-UHFFFAOYSA-N 0.000 abstract 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 abstract 1
- 206010020601 Hyperchlorhydria Diseases 0.000 abstract 1
- 208000007101 Muscle Cramp Diseases 0.000 abstract 1
- 208000005392 Spasm Diseases 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 abstract 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 abstract 1
- 229960004373 acetylcholine Drugs 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- -1 cinnamoyl Chemical group 0.000 abstract 1
- 125000000490 cinnamyl group Chemical group C(C=CC1=CC=CC=C1)* 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 210000004051 gastric juice Anatomy 0.000 abstract 1
- 150000002271 geminal diols Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 abstract 1
- QGKLPGKXAVVPOJ-UHFFFAOYSA-N pyrrolidin-3-one Chemical compound O=C1CCNC1 QGKLPGKXAVVPOJ-UHFFFAOYSA-N 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 231100000397 ulcer Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3220871 | 1971-07-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1301254A true GB1301254A (enrdf_load_stackoverflow) | 1972-12-29 |
Family
ID=10334987
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1301254D Expired GB1301254A (enrdf_load_stackoverflow) | 1971-07-08 | 1971-07-08 |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1301254A (enrdf_load_stackoverflow) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4855290A (en) * | 1985-05-10 | 1989-08-08 | State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research | Derivatives of quinuclidine |
| EP0337547A1 (en) * | 1988-04-11 | 1989-10-18 | Merck Sharp & Dohme Ltd. | Spirocyclic compounds incorporating five-membered rings with two heteroatoms |
| US4940795A (en) * | 1987-10-05 | 1990-07-10 | Yamanouchi Pharmaceutical Co., Ltd. | Heterocyclic spiro compounds and methods for preparing the same |
| US5157038A (en) * | 1989-08-10 | 1992-10-20 | Richter Gedeon Vegyeszeti Gyar Rt. | 2-oxo-1-oxa-8 azaspiro[4,5]decane derivatives, pharmaceutical compositions containing them and process for preparing same |
| US5407938A (en) * | 1990-04-10 | 1995-04-18 | Israel Institute For Biological Research | Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines) |
| JP2010540414A (ja) * | 2007-09-13 | 2010-12-24 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 塩基性反応条件下におけるアシル転位によって１，３−ジオキソラン−２−オン及びカルボン酸エステルを調製する方法 |
-
1971
- 1971-07-08 GB GB1301254D patent/GB1301254A/en not_active Expired
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4855290A (en) * | 1985-05-10 | 1989-08-08 | State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research | Derivatives of quinuclidine |
| US4940795A (en) * | 1987-10-05 | 1990-07-10 | Yamanouchi Pharmaceutical Co., Ltd. | Heterocyclic spiro compounds and methods for preparing the same |
| USRE34653E (en) * | 1987-10-05 | 1994-07-05 | Yamanouchi Pharmaceutical Co., Ltd. | Heterocyclic spiro compounds and methods for preparing the same |
| EP0337547A1 (en) * | 1988-04-11 | 1989-10-18 | Merck Sharp & Dohme Ltd. | Spirocyclic compounds incorporating five-membered rings with two heteroatoms |
| US5157038A (en) * | 1989-08-10 | 1992-10-20 | Richter Gedeon Vegyeszeti Gyar Rt. | 2-oxo-1-oxa-8 azaspiro[4,5]decane derivatives, pharmaceutical compositions containing them and process for preparing same |
| US5407938A (en) * | 1990-04-10 | 1995-04-18 | Israel Institute For Biological Research | Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines) |
| JP2010540414A (ja) * | 2007-09-13 | 2010-12-24 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 塩基性反応条件下におけるアシル転位によって１，３−ジオキソラン−２−オン及びカルボン酸エステルを調製する方法 |
| WO2009037111A3 (de) * | 2007-09-13 | 2011-09-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur herstellung von 1,3-dioxolan-2-onen sowie von carbonsäureestern durch transacylierung unter basischen reaktionsbedingungen |
| JP2014058515A (ja) * | 2007-09-13 | 2014-04-03 | Boehringer Ingelheim Pharma Gmbh & Co Kg | 塩基性反応条件下におけるアシル転位によって１，３−ジオキソラン−２−オン及びカルボン酸エステルを調製する方法 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |