GB1301254A - - Google Patents
Info
- Publication number
- GB1301254A GB1301254A GB1301254DA GB1301254A GB 1301254 A GB1301254 A GB 1301254A GB 1301254D A GB1301254D A GB 1301254DA GB 1301254 A GB1301254 A GB 1301254A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phch
- compounds
- piperidine
- oxo
- gastric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1301254 Spiroheterocyclic ketones YOSHITOMI PHARMACEUTICAL INDUSTRIES Ltd 8 July 1971 32208/71 Heading C2C The invention comprises compounds of formula and their pharmaceutically acceptable acid addition and quaternary ammonium salts, wherein R<SP>1</SP>, R<SP>2</SP> are each H, Me, Et, Ph, p-ClC 6 H 4 of PhCH 2 ; X is O or S; R<SP>3</SP> is H and R<SP>4</SP> is H, C 1-4 alkyl, MeO 2 C, EtO 2 C, MeCO, PhCO, PhCH 2 , PhCH 2 CH 2 , pyridylmethyl, pyridylethyl, furfuryl, thenyl, cinnamyl, cinnamoyl, allyl or propargyl; m+n=2 or 3, m=0 or 1 and n= 2 or 3; or R<SP>3</SP>-R<SP>4</SP> may be CH 2 -CH 2 when m = 2 and n = 1. These compounds are prepared by (i) reacting with HX-CR<SP>1</SP>R<SP>2</SP>-CO 2 H, the appropriate 3-oxo-pyrrolidine, -piperidine, or -quinuclidine, or 4-oxo-piperidine, or the corresponding gem-diols; (ii) N-substitition; or (iii) eliminating an N-CH 2 Ph, -CO 2 Me or -CO 2 Et group. Therapeutic compositions for oral or parenteral administration comprise compounds of the above formula, which have acetylcholine antagonistic and gastric juice secretion inhibiting activity, and may be used for treating gastroenteric spasms, gastric hyperacidities and gastro.enteric ulcers.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3220871 | 1971-07-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1301254A true GB1301254A (en) | 1972-12-29 |
Family
ID=10334987
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1301254D Expired GB1301254A (en) | 1971-07-08 | 1971-07-08 |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB1301254A (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4855290A (en) * | 1985-05-10 | 1989-08-08 | State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research | Derivatives of quinuclidine |
EP0337547A1 (en) * | 1988-04-11 | 1989-10-18 | Merck Sharp & Dohme Ltd. | Spirocyclic compounds incorporating five-membered rings with two heteroatoms |
US4940795A (en) * | 1987-10-05 | 1990-07-10 | Yamanouchi Pharmaceutical Co., Ltd. | Heterocyclic spiro compounds and methods for preparing the same |
US5157038A (en) * | 1989-08-10 | 1992-10-20 | Richter Gedeon Vegyeszeti Gyar Rt. | 2-oxo-1-oxa-8 azaspiro[4,5]decane derivatives, pharmaceutical compositions containing them and process for preparing same |
US5407938A (en) * | 1990-04-10 | 1995-04-18 | Israel Institute For Biological Research | Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines) |
WO2009037111A2 (en) * | 2007-09-13 | 2009-03-26 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Method for the production of 1,3-dioxolane-2-ones and carboxylic acid esters by means of transacylation in basic reaction conditions |
-
1971
- 1971-07-08 GB GB1301254D patent/GB1301254A/en not_active Expired
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4855290A (en) * | 1985-05-10 | 1989-08-08 | State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research | Derivatives of quinuclidine |
US4940795A (en) * | 1987-10-05 | 1990-07-10 | Yamanouchi Pharmaceutical Co., Ltd. | Heterocyclic spiro compounds and methods for preparing the same |
USRE34653E (en) * | 1987-10-05 | 1994-07-05 | Yamanouchi Pharmaceutical Co., Ltd. | Heterocyclic spiro compounds and methods for preparing the same |
EP0337547A1 (en) * | 1988-04-11 | 1989-10-18 | Merck Sharp & Dohme Ltd. | Spirocyclic compounds incorporating five-membered rings with two heteroatoms |
US5157038A (en) * | 1989-08-10 | 1992-10-20 | Richter Gedeon Vegyeszeti Gyar Rt. | 2-oxo-1-oxa-8 azaspiro[4,5]decane derivatives, pharmaceutical compositions containing them and process for preparing same |
US5407938A (en) * | 1990-04-10 | 1995-04-18 | Israel Institute For Biological Research | Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines) |
WO2009037111A2 (en) * | 2007-09-13 | 2009-03-26 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Method for the production of 1,3-dioxolane-2-ones and carboxylic acid esters by means of transacylation in basic reaction conditions |
JP2010540414A (en) * | 2007-09-13 | 2010-12-24 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | Process for the preparation of 1,3-dioxolan-2-one and carboxylic acid esters by acyl rearrangement under basic reaction conditions |
WO2009037111A3 (en) * | 2007-09-13 | 2011-09-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Method for the production of 1,3-dioxolane-2-ones and carboxylic acid esters by means of transacylation in basic reaction conditions |
JP2014058515A (en) * | 2007-09-13 | 2014-04-03 | Boehringer Ingelheim Pharma Gmbh & Co Kg | Method of preparing 1,3-dioxolane-2-one and carboxylate ester by acyl translocation under basic treatment condition |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |