GB1301225A - - Google Patents

Info

Publication number
GB1301225A
GB1301225A GB1301225DA GB1301225A GB 1301225 A GB1301225 A GB 1301225A GB 1301225D A GB1301225D A GB 1301225DA GB 1301225 A GB1301225 A GB 1301225A
Authority
GB
United Kingdom
Prior art keywords
mixture
jan
nitro
methyl
ethylene oxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GB1301225A publication Critical patent/GB1301225A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1301225 Nitro-imidazole derivative STAROGARDZKIE ZAKLADY FARMACEUTYCZNE POLFA 15 Jan 1971 [19 Jan 1970] 2083/71 Heading C2C 1 - (21 - Hydroxyethyl) - 2 - methyl - 5 - nitroimidazole is prepared by reacting the sulphate salt of 2-methyl-5-nitro-imidazole with ethylene oxide in an anhydrous reaction medium including a homogeneous mixture comprising (a) sulphuric acid and (b) a saturated aliphatic compound having a functional group containing at least one oxygen atom or a heterocyclic compound having at least one oxygen atom in the ring, and dosing the reaction mixture with alternately ethylene oxide and sulphuric acid to maintain the reactants and reaction products in solution in the mixture. The aliphatic compound may be an alcohol, ketone, carboxylic acid or carboxylic acid anhydride and the heterocyclic compound may be, for example, dioxan or tetrahydrofuran. The process may be effected at 10‹ to 50‹ C.
GB1301225D 1970-01-19 1971-01-15 Expired GB1301225A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL13825170A PL76606B1 (en) 1970-01-19 1970-01-19

Publications (1)

Publication Number Publication Date
GB1301225A true GB1301225A (en) 1972-12-29

Family

ID=19951199

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1301225D Expired GB1301225A (en) 1970-01-19 1971-01-15

Country Status (6)

Country Link
JP (1) JPS5417742B1 (en)
BG (1) BG18610A3 (en)
GB (1) GB1301225A (en)
PL (1) PL76606B1 (en)
SU (1) SU372816A3 (en)
YU (1) YU34406B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0150407A1 (en) * 1984-01-10 1985-08-07 BASF Aktiengesellschaft Process for the preparation of 1(2-hydroxyethyl)-2-methyl-5-nitroimidazole of high purity
CN104072424A (en) * 2013-03-29 2014-10-01 黄冈师范学院 Environmental novel co-production technology of metronidazole and composite fertilizer
CN107879983A (en) * 2017-12-21 2018-04-06 黄冈师范学院 A kind of metronidazole synthetic method of metronidazole synthesizer and the application device

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0150407A1 (en) * 1984-01-10 1985-08-07 BASF Aktiengesellschaft Process for the preparation of 1(2-hydroxyethyl)-2-methyl-5-nitroimidazole of high purity
CN104072424A (en) * 2013-03-29 2014-10-01 黄冈师范学院 Environmental novel co-production technology of metronidazole and composite fertilizer
CN107879983A (en) * 2017-12-21 2018-04-06 黄冈师范学院 A kind of metronidazole synthetic method of metronidazole synthesizer and the application device
CN107879983B (en) * 2017-12-21 2023-09-19 黄冈师范学院 Metronidazole synthesis device and Metronidazole synthesis method using same

Also Published As

Publication number Publication date
YU34406B (en) 1979-07-10
YU9471A (en) 1978-12-31
JPS5417742B1 (en) 1979-07-02
PL76606B1 (en) 1975-02-28
SU372816A3 (en) 1973-03-01
BG18610A3 (en) 1975-02-25

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee