GB1299232A - Derivatives of cephalosporin - Google Patents
Derivatives of cephalosporinInfo
- Publication number
- GB1299232A GB1299232A GB50184/70A GB5018470A GB1299232A GB 1299232 A GB1299232 A GB 1299232A GB 50184/70 A GB50184/70 A GB 50184/70A GB 5018470 A GB5018470 A GB 5018470A GB 1299232 A GB1299232 A GB 1299232A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- formula
- phenyl
- give
- nitroso
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930186147 Cephalosporin Natural products 0.000 title 1
- 229940124587 cephalosporin Drugs 0.000 title 1
- 150000001780 cephalosporins Chemical class 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 5
- 150000002832 nitroso derivatives Chemical class 0.000 abstract 5
- -1 amino-substituted phenyl Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 3
- 125000006501 nitrophenyl group Chemical group 0.000 abstract 3
- XLYVHYXTFHZCNY-UHFFFAOYSA-N 2-[carboxymethyl(nitroso)amino]acetic acid Chemical class OC(=O)CN(N=O)CC(O)=O XLYVHYXTFHZCNY-UHFFFAOYSA-N 0.000 abstract 2
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- UOLQIVBUKGCJAK-UHFFFAOYSA-N 2-bromo-2-nitro-2-phenylacetic acid Chemical compound OC(=O)C(Br)([N+]([O-])=O)C1=CC=CC=C1 UOLQIVBUKGCJAK-UHFFFAOYSA-N 0.000 abstract 1
- WAKFRZBXTKUFIW-UHFFFAOYSA-N 2-bromo-2-phenylacetic acid Chemical compound OC(=O)C(Br)C1=CC=CC=C1 WAKFRZBXTKUFIW-UHFFFAOYSA-N 0.000 abstract 1
- CMWKITSNTDAEDT-UHFFFAOYSA-N 2-nitrobenzaldehyde Chemical compound [O-][N+](=O)C1=CC=CC=C1C=O CMWKITSNTDAEDT-UHFFFAOYSA-N 0.000 abstract 1
- YLGCHHNOHCFUOD-UHFFFAOYSA-N 3-ethoxy-2-(methylamino)-3-oxo-2-phenylpropanoic acid Chemical compound C(C)OC(=O)C(C(=O)O)(C1=CC=CC=C1)NC YLGCHHNOHCFUOD-UHFFFAOYSA-N 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 abstract 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 1
- 235000011054 acetic acid Nutrition 0.000 abstract 1
- 150000001242 acetic acid derivatives Chemical class 0.000 abstract 1
- 150000008065 acid anhydrides Chemical class 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 abstract 1
- 239000003610 charcoal Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000012024 dehydrating agents Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000006187 pill Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/04—1,2,3-Oxadiazoles; Hydrogenated 1,2,3-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR696936248A FR2068416B1 (enrdf_load_stackoverflow) | 1969-10-22 | 1969-10-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1299232A true GB1299232A (en) | 1972-12-13 |
Family
ID=9041916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB50184/70A Expired GB1299232A (en) | 1969-10-22 | 1970-10-22 | Derivatives of cephalosporin |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JPS4925954B1 (enrdf_load_stackoverflow) |
| BE (1) | BE757792A (enrdf_load_stackoverflow) |
| CH (1) | CH531008A (enrdf_load_stackoverflow) |
| DE (1) | DE2051990A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2068416B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1299232A (enrdf_load_stackoverflow) |
| IL (1) | IL35404A (enrdf_load_stackoverflow) |
| NL (1) | NL7015421A (enrdf_load_stackoverflow) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1584713A (enrdf_load_stackoverflow) * | 1967-01-18 | 1970-01-02 |
-
0
- BE BE757792D patent/BE757792A/xx unknown
-
1969
- 1969-10-22 FR FR696936248A patent/FR2068416B1/fr not_active Expired
-
1970
- 1970-10-06 IL IL35404A patent/IL35404A/en unknown
- 1970-10-20 CH CH1546770A patent/CH531008A/fr not_active IP Right Cessation
- 1970-10-20 JP JP45091696A patent/JPS4925954B1/ja active Pending
- 1970-10-21 NL NL7015421A patent/NL7015421A/xx unknown
- 1970-10-22 DE DE19702051990 patent/DE2051990A1/de active Pending
- 1970-10-22 GB GB50184/70A patent/GB1299232A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH531008A (fr) | 1972-11-30 |
| NL7015421A (enrdf_load_stackoverflow) | 1971-04-26 |
| FR2068416B1 (enrdf_load_stackoverflow) | 1973-01-12 |
| FR2068416A1 (enrdf_load_stackoverflow) | 1971-08-27 |
| DE2051990A1 (de) | 1971-04-29 |
| BE757792A (fr) | 1971-04-21 |
| IL35404A0 (en) | 1970-12-24 |
| JPS4925954B1 (enrdf_load_stackoverflow) | 1974-07-04 |
| IL35404A (en) | 1973-10-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |