GB1297306A - - Google Patents
Info
- Publication number
- GB1297306A GB1297306A GB1297306DA GB1297306A GB 1297306 A GB1297306 A GB 1297306A GB 1297306D A GB1297306D A GB 1297306DA GB 1297306 A GB1297306 A GB 1297306A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methoxy
- naphthyl
- prepared
- compounds
- acetyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/41—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrogenolysis or reduction of carboxylic groups or functional derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1297306 Naphthyl - propanals and intermediates therefor SYNTEX CORP 10 March 1970 [9 Oct 1969] 11483/70 Heading C2C Novel d-compounds III: where R is Me, Et, iso-Pr, cyclopropyl, CF 3 , F, Cl, vinyl, ethynyl, MeO, MeS, methoxy-methoxy, methoxymethylthio, difluoromethoxy or difluoromethylthio, are made by oxidizing compounds II (prepared from corresponding propionic acids) or by reducing compounds I (prepared by α-methylation of corresponding acetic acids usually in the methyl ester form; the acetic acids are prepared by reacting 2-acetyl-6- R-substituted naphthalenes with a morpholinesulphur mixture followed by treatment with HC1 and neutralization with, e.g. sodium hydroxide). The following starting materials and intermediates are also described and exemplified:-2 - acetyl - 6 - methoxy - naphthalene, methyl - 2 - (6 - methoxy - 2 - naphthyl)- propionate and a cinchonidine salt with 2-(6- methoxy-2-naphthyl) propionic acid {treatment with hydrochloric acid affords d-2-(6-methoxy-2- naphthyl) propionic acid which yields l-2-(6- methoxy-2-naphthyl)-1 -propanol upon reduction with lithium aluminium hydride}. Pharmaceutical preparations suitable for treating inflammation contain III as active ingredient; they also show analgesic and anti-pyretic action. Administration is usually orally.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86521669A | 1969-10-09 | 1969-10-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1297306A true GB1297306A (en) | 1972-11-22 |
Family
ID=25344966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1297306D Expired GB1297306A (en) | 1969-10-09 | 1970-03-10 |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS54908B1 (en) |
| BE (1) | BE747925A (en) |
| BR (1) | BR6915468D0 (en) |
| CA (1) | CA921492A (en) |
| CH (2) | CH549547A (en) |
| DE (2) | DE2043048C3 (en) |
| DK (1) | DK145820C (en) |
| ES (2) | ES383496A1 (en) |
| FI (1) | FI50521C (en) |
| FR (1) | FR2068541B1 (en) |
| GB (1) | GB1297306A (en) |
| IL (1) | IL33947A (en) |
| NL (1) | NL7004198A (en) |
| NO (1) | NO131593C (en) |
| SE (1) | SE362066B (en) |
| ZA (1) | ZA701177B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4912248A (en) * | 1987-05-18 | 1990-03-27 | The Procter & Gamble Company | Novel anti-inflammatory agents, pharmaceutical compositions and methods for reducing inflammation |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1474377A (en) * | 1973-09-11 | 1977-05-25 | Beecham Group Ltd | Naphthalene derivatives |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3562336A (en) * | 1968-07-24 | 1971-02-09 | Syntex Corp | Synthesis of naphthalene derivatives |
| US3637767A (en) * | 1968-07-30 | 1972-01-25 | Syntex Corp | 2-(6'-methoxynaphth-2'-yl)propylene oxide and 5'-halo derivatives |
-
1969
- 1969-12-19 BR BR215468/69A patent/BR6915468D0/en unknown
-
1970
- 1970-02-23 ZA ZA701177A patent/ZA701177B/en unknown
- 1970-02-23 IL IL33947A patent/IL33947A/en unknown
- 1970-02-23 CA CA075524A patent/CA921492A/en not_active Expired
- 1970-03-05 FI FI700605A patent/FI50521C/en active
- 1970-03-10 GB GB1297306D patent/GB1297306A/en not_active Expired
- 1970-03-20 NO NO1043/70A patent/NO131593C/no unknown
- 1970-03-24 NL NL7004198A patent/NL7004198A/xx unknown
- 1970-03-24 JP JP2479570A patent/JPS54908B1/ja active Pending
- 1970-03-25 BE BE747925D patent/BE747925A/en not_active IP Right Cessation
- 1970-04-14 DK DK186170A patent/DK145820C/en not_active IP Right Cessation
- 1970-04-20 FR FR707014295A patent/FR2068541B1/fr not_active Expired
- 1970-08-10 SE SE10932/70A patent/SE362066B/xx unknown
- 1970-08-27 CH CH1286570A patent/CH549547A/en not_active IP Right Cessation
- 1970-08-27 CH CH149873A patent/CH546724A/en not_active IP Right Cessation
- 1970-08-31 DE DE2043048A patent/DE2043048C3/en not_active Expired
- 1970-08-31 DE DE2065420A patent/DE2065420C2/en not_active Expired
- 1970-09-09 ES ES70383496A patent/ES383496A1/en not_active Expired
-
1973
- 1973-04-02 ES ES413265A patent/ES413265A1/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4912248A (en) * | 1987-05-18 | 1990-03-27 | The Procter & Gamble Company | Novel anti-inflammatory agents, pharmaceutical compositions and methods for reducing inflammation |
Also Published As
| Publication number | Publication date |
|---|---|
| FI50521C (en) | 1976-04-12 |
| IL33947A0 (en) | 1970-04-20 |
| DK145820B (en) | 1983-03-14 |
| CH546724A (en) | 1974-03-15 |
| ES413265A1 (en) | 1976-06-16 |
| DE2043048C3 (en) | 1974-06-27 |
| BR6915468D0 (en) | 1973-03-13 |
| BE747925A (en) | 1970-08-31 |
| JPS54908B1 (en) | 1979-01-18 |
| CA921492A (en) | 1973-02-20 |
| NO131593B (en) | 1975-03-17 |
| DE2043048A1 (en) | 1971-04-22 |
| FR2068541A1 (en) | 1971-08-27 |
| ES383496A1 (en) | 1973-07-01 |
| NL7004198A (en) | 1971-04-14 |
| SE362066B (en) | 1973-11-26 |
| DE2065420C2 (en) | 1982-07-22 |
| ZA701177B (en) | 1971-09-29 |
| NO131593C (en) | 1975-07-02 |
| DK145820C (en) | 1983-09-05 |
| DE2043048B2 (en) | 1973-11-15 |
| DE2065420A1 (en) | 1973-07-05 |
| IL33947A (en) | 1973-06-29 |
| FR2068541B1 (en) | 1973-04-06 |
| FI50521B (en) | 1975-12-31 |
| CH549547A (en) | 1974-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PE20 | Patent expired after termination of 20 years |