GB1291670A - A new 4-substituted-1,4-benzothiazine derivative, its preparation, and its medicinal use - Google Patents
A new 4-substituted-1,4-benzothiazine derivative, its preparation, and its medicinal useInfo
- Publication number
- GB1291670A GB1291670A GB26506/71A GB2650671A GB1291670A GB 1291670 A GB1291670 A GB 1291670A GB 26506/71 A GB26506/71 A GB 26506/71A GB 2650671 A GB2650671 A GB 2650671A GB 1291670 A GB1291670 A GB 1291670A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dioxide
- octahydro
- benzothiazine
- reacting
- april
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 4-substituted-1,4-benzothiazine Chemical class 0.000 title 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- PIBTWIUHKLSIBC-UHFFFAOYSA-N 1,1-dioxo-2,3,4a,5,6,7,8,8a-octahydrobenzo[b][1,4]thiazin-4-amine Chemical compound C1CCCC2N(N)CCS(=O)(=O)C21 PIBTWIUHKLSIBC-UHFFFAOYSA-N 0.000 abstract 2
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 abstract 2
- NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 abstract 1
- ZOQHCWIALKKWJO-UHFFFAOYSA-N 1-(2-hydroxyethylsulfanyl)cyclohexan-1-ol Chemical compound OCCSC1(CCCCC1)O ZOQHCWIALKKWJO-UHFFFAOYSA-N 0.000 abstract 1
- SXINBFXPADXIEY-UHFFFAOYSA-N 5-Nitrofurfural Chemical compound [O-][N+](=O)C1=CC=C(C=O)O1 SXINBFXPADXIEY-UHFFFAOYSA-N 0.000 abstract 1
- KNIUHBNRWZGIQQ-UHFFFAOYSA-N 7-diethoxyphosphinothioyloxy-4-methylchromen-2-one Chemical compound CC1=CC(=O)OC2=CC(OP(=S)(OCC)OCC)=CC=C21 KNIUHBNRWZGIQQ-UHFFFAOYSA-N 0.000 abstract 1
- 230000002058 anti-hyperglycaemic effect Effects 0.000 abstract 1
- 230000001099 anti-trypanosomal effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- ZWAJLVLEBYIOTI-UHFFFAOYSA-N cyclohexene oxide Chemical compound C1CCCC2OC21 ZWAJLVLEBYIOTI-UHFFFAOYSA-N 0.000 abstract 1
- FWFSEYBSWVRWGL-UHFFFAOYSA-N cyclohexene oxide Natural products O=C1CCCC=C1 FWFSEYBSWVRWGL-UHFFFAOYSA-N 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- DDNQZTXQNGVXSP-UHFFFAOYSA-N n-(1,1-dioxo-2,3,4a,5,6,7,8,8a-octahydrobenzo[b][1,4]thiazin-4-yl)-1-(5-nitrofuran-2-yl)methanimine Chemical compound O1C([N+](=O)[O-])=CC=C1C=NN1C2CCCCC2S(=O)(=O)CC1 DDNQZTXQNGVXSP-UHFFFAOYSA-N 0.000 abstract 1
- IAIWVQXQOWNYOU-FPYGCLRLSA-N nitrofural Chemical class NC(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 IAIWVQXQOWNYOU-FPYGCLRLSA-N 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001174 sulfone group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19702020298 DE2020298A1 (de) | 1970-04-25 | 1970-04-25 | 4-(5'-Nitrofurfuryliden-amino)-octahydro-4H-1,4-benz-thiazin-1,1-dioxid,ein Verfahren zu seiner Herstellung und seine Verwendung als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1291670A true GB1291670A (en) | 1972-10-04 |
Family
ID=5769375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB26506/71A Expired GB1291670A (en) | 1970-04-25 | 1971-04-19 | A new 4-substituted-1,4-benzothiazine derivative, its preparation, and its medicinal use |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3755308A (enExample) |
| BE (1) | BE766198A (enExample) |
| CH (1) | CH552621A (enExample) |
| DE (1) | DE2020298A1 (enExample) |
| FR (1) | FR2092092B1 (enExample) |
| GB (1) | GB1291670A (enExample) |
| IL (1) | IL36531A0 (enExample) |
| NL (1) | NL7105567A (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4124458A (en) * | 1977-07-11 | 1978-11-07 | Innova, Inc. | Mass-transfer membrane and processes using same |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1170957B (de) * | 1962-11-23 | 1964-05-27 | Bayer Ag | Verfahren zur Herstellung von 5-Nitro-furfuryliden-(2)-iminoderivaten |
| DE1670840A1 (de) * | 1967-03-31 | 1971-03-11 | Bayer Ag | Verfahren zur Herstellung von Tetra-hydro-1,4-thiazin-1,1-dioxiden |
-
1970
- 1970-04-25 DE DE19702020298 patent/DE2020298A1/de active Pending
-
1971
- 1971-04-01 IL IL36531A patent/IL36531A0/xx unknown
- 1971-04-02 CH CH479771A patent/CH552621A/xx not_active IP Right Cessation
- 1971-04-19 GB GB26506/71A patent/GB1291670A/en not_active Expired
- 1971-04-19 US US00135375A patent/US3755308A/en not_active Expired - Lifetime
- 1971-04-23 FR FR7114667A patent/FR2092092B1/fr not_active Expired
- 1971-04-23 BE BE766198A patent/BE766198A/xx unknown
- 1971-04-23 NL NL7105567A patent/NL7105567A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2092092A1 (enExample) | 1972-01-21 |
| NL7105567A (enExample) | 1971-10-27 |
| CH552621A (de) | 1974-08-15 |
| DE2020298A1 (de) | 1971-11-11 |
| BE766198A (fr) | 1971-10-25 |
| FR2092092B1 (enExample) | 1974-10-18 |
| IL36531A0 (en) | 1971-06-23 |
| US3755308A (en) | 1973-08-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |