GB1290594A - - Google Patents

Info

Publication number
GB1290594A
GB1290594A GB1290594DA GB1290594A GB 1290594 A GB1290594 A GB 1290594A GB 1290594D A GB1290594D A GB 1290594DA GB 1290594 A GB1290594 A GB 1290594A
Authority
GB
United Kingdom
Prior art keywords
prepared
april
reacting
adenine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GB1290594A publication Critical patent/GB1290594A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Invalid Beds And Related Equipment (AREA)

Abstract

1290594 Adenine derivatives TANABE SEIYAKU CO Ltd 8 April 1970 [9 April 1969 26 May 1969 (2) 30 May 1969] 16613/70 Heading C2C The invention comprises compounds of formula wherein X and Y are each H (Ia) or XY is RR<SP>1</SP>C= (e.g. Me 2 C, MeCH or PhCH) (Ib), and Z is H or a salt-forming atom or group. Ia is isolated from the mushroom Lentinus edodes Sing., and may be prepared by (a) hydrolysing Ib, (b) desulphurizing (e.g. with Raney Ni) its 8-SH derivatives, or (c) reacting with HCO 2 H (or, e.g. HCONH 2 ), 4-(5,6-diamino-4-pyrimidylamino)-2,3-dihydroxybutyric acid (obtained by reducing the 5-nitro - 6 -aminopyrimidine analogue). Ib is prepared by reacting erythronolactone acetal or ketal (with RR<SP>1</SP>CO) with a metal salt of adenine at its 9-position. Also prepared is Ia (Z=Me). Therapeutic compositions for oral or parenteral administration comprise the above compound (Ia) (or its pharmaceutically acceptable salts), which is a hypocholesterolemic agent.
GB1290594D 1969-04-09 1970-04-08 Expired GB1290594A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2778769 1969-04-09
JP4113169 1969-05-26
JP4113069 1969-05-26
JP4262369 1969-05-30

Publications (1)

Publication Number Publication Date
GB1290594A true GB1290594A (en) 1972-09-27

Family

ID=27458759

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1290594D Expired GB1290594A (en) 1969-04-09 1970-04-08

Country Status (7)

Country Link
BE (1) BE748658A (en)
DE (1) DE2017081A1 (en)
FR (1) FR2042314B1 (en)
GB (1) GB1290594A (en)
IL (1) IL34188A (en)
NL (1) NL7005039A (en)
NO (1) NO124836B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL64501A (en) * 1980-12-22 1985-07-31 Astra Laekemedel Ab 9-substituted 4-hydroxybutyl guanine derivatives,their preparation and antiviral use
EP3763406A1 (en) 2019-07-12 2021-01-13 Sanofi Method and electronic device for acquiring delivery information

Also Published As

Publication number Publication date
BE748658A (en) 1970-09-06
FR2042314A1 (en) 1971-02-12
FR2042314B1 (en) 1974-01-11
NL7005039A (en) 1970-10-13
IL34188A0 (en) 1970-05-21
DE2017081A1 (en) 1970-10-22
NO124836B (en) 1972-06-12
IL34188A (en) 1972-12-29

Similar Documents

Publication Publication Date Title
IE45256L (en) Quinazolone derivatives
GB1442118A (en) Piperidine derivatives
GB1461209A (en) Thienyl and thietyl compounds
GB1373212A (en) Pyrazole compounds
GB1507957A (en) Nitrofuryl-pyrazole derivatives methods for producing them and medicaments comprising them
GB1285400A (en) Esters of substituted anthranilic acid
GB1481813A (en) Substituted thiazolinylidenyl ketones and their pharmaceutical compositions
GB1290594A (en)
GB1239553A (en)
GB1373548A (en) Anti-hypertensive 6-substituted 3-hydrazino-pyridazines and their preparation
GB1367785A (en) 2-substituted adenosine derivatives and the production thereof
ES450897A1 (en) N-Tetrahydrofurfuryl-noroxymorphones, their salts, and analgesic compositions and methods employing them
GB1506302A (en) 1-alkyl-2-(phenoxymethyl)-5-nitro-imidazoles and processes for their preparation
GB1394791A (en) Diphenylalkyllactamimide derivatives
GB1500962A (en) Furo(2,3-d)pyrimidine derivatives
JPS56128783A (en) Beta-lactam antibacterial compound, its manufacture and its medicinal compound
GB1242160A (en) Isoquinolines
GB1308029A (en) Indole derivatives
IE43117L (en) Naphthacene derivatives
GB1373900A (en) Corticoid ester and method of preparing it
GB1229509A (en)
GB1299421A (en) 3-substituted amino-6-hydrazino-pyridazines
GB1181520A (en) Substituted 1-Aminoadamantanes
GB1219387A (en) Bicyclo[2.2.2]oct-2-ene-amino acid compounds
GB1381833A (en) Amino acid derivatives

Legal Events

Date Code Title Description
CSNS Application of which complete specification have been accepted and published, but patent is not sealed