GB1287493A - Methylenetetracycline esters - Google Patents
Methylenetetracycline estersInfo
- Publication number
- GB1287493A GB1287493A GB37360/70A GB3736070A GB1287493A GB 1287493 A GB1287493 A GB 1287493A GB 37360/70 A GB37360/70 A GB 37360/70A GB 3736070 A GB3736070 A GB 3736070A GB 1287493 A GB1287493 A GB 1287493A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- tetracycline
- acid
- ester
- esters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002148 esters Chemical class 0.000 title abstract 3
- 239000004098 Tetracycline Substances 0.000 abstract 3
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 3
- 229960002180 tetracycline Drugs 0.000 abstract 3
- 229930101283 tetracycline Natural products 0.000 abstract 3
- 235000019364 tetracycline Nutrition 0.000 abstract 3
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- CCIVGXIOQKPBKL-UHFFFAOYSA-N ethanesulfonic acid Chemical compound CCS(O)(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-N 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- HEZHYQDYRPUXNJ-UHFFFAOYSA-L potassium dithionite Chemical compound [K+].[K+].[O-]S(=O)S([O-])=O HEZHYQDYRPUXNJ-UHFFFAOYSA-L 0.000 abstract 1
- 239000012429 reaction media Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- -1 tetracycline ester Chemical class 0.000 abstract 1
- 150000003522 tetracyclines Chemical class 0.000 abstract 1
- 239000011701 zinc Substances 0.000 abstract 1
- 229910052725 zinc Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2069969 | 1969-08-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1287493A true GB1287493A (en) | 1972-08-31 |
Family
ID=11170732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB37360/70A Expired GB1287493A (en) | 1969-08-08 | 1970-08-03 | Methylenetetracycline esters |
Country Status (12)
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1430859A (enrdf_load_stackoverflow) * | 1960-05-23 | 1966-05-25 | ||
| US3145228A (en) * | 1962-09-06 | 1964-08-18 | Pfizer & Co C | 5-alkoxy-and 5-benzyloxy-tetracycline, derivatives and analogues thereof |
-
0
- BE BE754596D patent/BE754596A/xx unknown
-
1969
- 1969-12-19 BR BR215437/69A patent/BR6915437D0/pt unknown
-
1970
- 1970-07-27 NL NL7011074A patent/NL7011074A/xx unknown
- 1970-08-03 FR FR7028566A patent/FR2068473B1/fr not_active Expired
- 1970-08-03 GB GB37360/70A patent/GB1287493A/en not_active Expired
- 1970-08-05 ZA ZA705429A patent/ZA705429B/xx unknown
- 1970-08-05 CA CA089945A patent/CA931946A/en not_active Expired
- 1970-08-05 NO NO3021/70A patent/NO131782C/no unknown
- 1970-08-06 AT AT716470A patent/AT297931B/de not_active IP Right Cessation
- 1970-08-07 CH CH1195770A patent/CH539612A/de not_active IP Right Cessation
- 1970-08-07 ES ES382541A patent/ES382541A1/es not_active Expired
- 1970-08-07 SE SE10847/70A patent/SE360071B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA931946A (en) | 1973-08-14 |
| FR2068473B1 (enrdf_load_stackoverflow) | 1974-08-30 |
| NO131782B (enrdf_load_stackoverflow) | 1975-04-21 |
| FR2068473A1 (enrdf_load_stackoverflow) | 1971-08-27 |
| BE754596A (fr) | 1971-02-08 |
| NL7011074A (enrdf_load_stackoverflow) | 1971-02-10 |
| AT297931B (de) | 1972-04-10 |
| NO131782C (enrdf_load_stackoverflow) | 1975-07-30 |
| SE360071B (enrdf_load_stackoverflow) | 1973-09-17 |
| ZA705429B (en) | 1971-04-28 |
| ES382541A1 (es) | 1972-12-01 |
| CH539612A (de) | 1973-07-31 |
| BR6915437D0 (pt) | 1973-01-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 414F | Notice of opposition given (sect. 14/1949) | ||
| 414A | Case decided by the comptroller ** specification amended (sect. 14/1949) | ||
| 49R | Reference inserted (sect. 9/1949) | ||
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |