GB1282376A - Benzofuran derivative - Google Patents
Benzofuran derivativeInfo
- Publication number
- GB1282376A GB1282376A GB54947/70A GB5494770A GB1282376A GB 1282376 A GB1282376 A GB 1282376A GB 54947/70 A GB54947/70 A GB 54947/70A GB 5494770 A GB5494770 A GB 5494770A GB 1282376 A GB1282376 A GB 1282376A
- Authority
- GB
- United Kingdom
- Prior art keywords
- benzofuran
- dihydro
- reacted
- dimethyl
- give
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Furan Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1282376 Benzofuran derivatives J R GEIGY AG 19 Nov 1970 [20 Nov 1969] 54947/70 Addition to 1266766 Heading C2C Novel 2,3-dihydro-5-(2-methylene-valeryl)- 6,7.dimethyl-benzofuran-2-carboxylic acid is prepared by decomposition of compounds I in which Am is a secondary amino group, to effect cleavage of the base H-Am. The starting material may be prepared thus: 2,3-Dimethylphenol and malic acid are reacted with H 2 SO 4 to give 7,8-dimethylcoumarin, which is then reacted with Br 2 and the bromine derivative decomposed in ethanolic KOH to 6,7- dimethyl-benzofuran-2-carboxylic acid; the latter is then reduced to give the 2,3-dihydro-derivative which is reacted with AlCl 3 and valeryl chloride to give 2,3-dihydro-5-valeryl-6,7-dimethyl-benzofuran-2-carboxylic acid; the latter on reaction with formaldehyde and H-Am yields the starting material which is not isolated. Pharmaceutical compositions comprise the novel compound together with a suitable carrier and are administered orally as diuretics and saluretics.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1727269 | 1969-11-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1282376A true GB1282376A (en) | 1972-07-19 |
Family
ID=4424103
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB54947/70A Expired GB1282376A (en) | 1969-11-20 | 1970-11-19 | Benzofuran derivative |
Country Status (7)
Country | Link |
---|---|
BE (1) | BE759137R (en) |
ES (1) | ES385700A2 (en) |
FR (1) | FR2073395B2 (en) |
GB (1) | GB1282376A (en) |
IE (1) | IE34748B1 (en) |
NL (1) | NL7016684A (en) |
ZA (1) | ZA707821B (en) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH484092A (en) * | 1967-07-28 | 1970-01-15 | Geigy Ag J R | Process for the preparation of new heterocyclic carboxylic acids |
CH510007A (en) * | 1968-05-30 | 1971-07-15 | Ciba Geigy Ag | Process for the preparation of new heterocyclic carboxylic acids |
-
0
- BE BE759137D patent/BE759137R/en active
-
1970
- 1970-11-13 NL NL7016684A patent/NL7016684A/xx unknown
- 1970-11-19 IE IE1489/70A patent/IE34748B1/en unknown
- 1970-11-19 GB GB54947/70A patent/GB1282376A/en not_active Expired
- 1970-11-19 ZA ZA707821A patent/ZA707821B/en unknown
- 1970-11-19 ES ES385700A patent/ES385700A2/en not_active Expired
- 1970-11-19 FR FR707041565A patent/FR2073395B2/fr not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ZA707821B (en) | 1971-08-25 |
IE34748L (en) | 1971-05-20 |
FR2073395A2 (en) | 1971-10-01 |
FR2073395B2 (en) | 1974-02-22 |
NL7016684A (en) | 1971-05-24 |
ES385700A2 (en) | 1973-04-01 |
BE759137R (en) | 1971-05-19 |
IE34748B1 (en) | 1975-08-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |