GB1273653A - Derivatives of phenolic amino alcohols - Google Patents
Derivatives of phenolic amino alcoholsInfo
- Publication number
- GB1273653A GB1273653A GB32589/70A GB3258970A GB1273653A GB 1273653 A GB1273653 A GB 1273653A GB 32589/70 A GB32589/70 A GB 32589/70A GB 3258970 A GB3258970 A GB 3258970A GB 1273653 A GB1273653 A GB 1273653A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- phenyl
- radical
- prepared
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 of phenolic amino alcohols Chemical class 0.000 title abstract 18
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 125000003545 alkoxy group Chemical group 0.000 abstract 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 7
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 6
- 238000006243 chemical reaction Methods 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 6
- 150000002367 halogens Chemical class 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 125000001424 substituent group Chemical group 0.000 abstract 5
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000003282 alkyl amino group Chemical group 0.000 abstract 3
- 125000005153 alkyl sulfamoyl group Chemical group 0.000 abstract 3
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 3
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 3
- 125000004414 alkyl thio group Chemical group 0.000 abstract 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 3
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 3
- 125000005010 perfluoroalkyl group Chemical group 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical class 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- WVDDGKGOMKODPV-UHFFFAOYSA-N hydroxymethyl benzene Natural products OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 abstract 2
- 230000008707 rearrangement Effects 0.000 abstract 2
- 238000006722 reduction reaction Methods 0.000 abstract 2
- LYYLNHQBPJMNKH-UHFFFAOYSA-N 2-(dibenzylamino)-1-(3-phenylmethoxyphenyl)propan-1-one Chemical compound C(C1=CC=CC=C1)OC=1C=C(C=CC=1)C(C(C)N(CC1=CC=CC=C1)CC1=CC=CC=C1)=O LYYLNHQBPJMNKH-UHFFFAOYSA-N 0.000 abstract 1
- HYSGMARVGYKWCL-UHFFFAOYSA-N 2-bromo-1-(3-phenylmethoxyphenyl)propan-1-one Chemical compound CC(Br)C(=O)C1=CC=CC(OCC=2C=CC=CC=2)=C1 HYSGMARVGYKWCL-UHFFFAOYSA-N 0.000 abstract 1
- MGRYVEDNIGXKQE-UHFFFAOYSA-N 2-bromo-4-methoxy-1-methylbenzene Chemical compound COC1=CC=C(C)C(Br)=C1 MGRYVEDNIGXKQE-UHFFFAOYSA-N 0.000 abstract 1
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical compound [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- BWLUMTFWVZZZND-UHFFFAOYSA-N Dibenzylamine Chemical compound C=1C=CC=CC=1CNCC1=CC=CC=C1 BWLUMTFWVZZZND-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000007818 Grignard reagent Substances 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 125000002723 alicyclic group Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 235000019445 benzyl alcohol Nutrition 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000010531 catalytic reduction reaction Methods 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 150000004795 grignard reagents Chemical class 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 150000002923 oximes Chemical class 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- FVSKHRXBFJPNKK-UHFFFAOYSA-N propionitrile Chemical compound CCC#N FVSKHRXBFJPNKK-UHFFFAOYSA-N 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84512069A | 1969-07-10 | 1969-07-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1273653A true GB1273653A (en) | 1972-05-10 |
Family
ID=25294452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB32589/70A Expired GB1273653A (en) | 1969-07-10 | 1970-07-06 | Derivatives of phenolic amino alcohols |
Country Status (14)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4138581A (en) * | 1969-04-01 | 1979-02-06 | Sterling Drugs Inc. | 3(Hydroxy or hydroxymethyl)-4(hydroxy)-α-(aminomethyl)benzyl alcohols |
| US4336400A (en) * | 1969-04-01 | 1982-06-22 | Sterling Drug Inc. | 3-(Hydroxy or hydroxymethyl)-4-hydroxy-alpha(aminomethyl)benzyl alcohols and methods of use |
| GB1346401A (en) * | 1971-05-12 | 1974-02-13 | Lepetit Spa | Cardioactive arylaminobutanols |
| US3928426A (en) * | 1972-01-28 | 1975-12-23 | Robins Co Inc A H | 1-Cyclopropyl-1-phenyl-omega-amino-1-lower alkanoyloxyalkanes |
| US4001429A (en) * | 1974-04-01 | 1977-01-04 | A. H. Robins Company, Incorporated | 1-Cyclopropyl-1-phenyl-ω-amino-1-alkanols and 1-lower-alkylacyl derivatives as analgetics |
| JPS556625B2 (enrdf_load_stackoverflow) * | 1974-05-16 | 1980-02-18 | ||
| JPS52171571U (enrdf_load_stackoverflow) * | 1976-06-16 | 1977-12-27 | ||
| JPS53114564U (enrdf_load_stackoverflow) * | 1977-02-16 | 1978-09-12 | ||
| DE2817494A1 (de) * | 1977-05-03 | 1978-11-09 | Continental Pharma | Aminoalkohol-derivat |
| JPS6210048A (ja) * | 1985-07-04 | 1987-01-19 | Microbial Chem Res Found | 新規生理活性物質ｍｈ４３５ |
| US5220063A (en) * | 1991-05-10 | 1993-06-15 | Hoechst Celanese Corporation | Method for the preparation of arylalkanolacylamides |
| CN116332774A (zh) * | 2023-03-29 | 2023-06-27 | 成都瑞尔医药科技有限公司 | 一种高手性纯度的重酒石酸间羟胺的制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2442797A (en) * | 1943-10-05 | 1948-06-08 | Sharp & Dohme Inc | Para-amino benzoic acid esters |
| FR1537803A (fr) * | 1966-07-14 | 1968-08-30 | Diwag Chemische Fabriken Gmbh | Procédé pour fabriquer des acylaminophénolalcanols |
-
1969
- 1969-07-10 US US00845120A patent/US3714229A/en not_active Expired - Lifetime
- 1969-12-05 BR BR214798/69A patent/BR6914798D0/pt unknown
-
1970
- 1970-06-18 ZA ZA704157A patent/ZA704157B/xx unknown
- 1970-06-25 NL NL7009390A patent/NL7009390A/xx unknown
- 1970-07-01 IL IL34831A patent/IL34831A0/xx unknown
- 1970-07-02 AU AU17100/70A patent/AU1710070A/en not_active Expired
- 1970-07-06 GB GB32589/70A patent/GB1273653A/en not_active Expired
- 1970-07-08 CH CH1033670A patent/CH565138A5/xx not_active IP Right Cessation
- 1970-07-09 ES ES381597A patent/ES381597A1/es not_active Expired
- 1970-07-09 BE BE753237D patent/BE753237A/xx unknown
- 1970-07-09 DK DK358870AA patent/DK138418B/da unknown
- 1970-07-09 SE SE7009536A patent/SE383511B/xx unknown
- 1970-07-10 FR FR707025768A patent/FR2059503B1/fr not_active Expired
- 1970-07-10 JP JP45060028A patent/JPS5220463B1/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| SE383511B (sv) | 1976-03-15 |
| DK138418C (enrdf_load_stackoverflow) | 1979-02-12 |
| CH565138A5 (enrdf_load_stackoverflow) | 1975-08-15 |
| BE753237A (fr) | 1971-01-11 |
| ES381597A1 (es) | 1973-04-16 |
| FR2059503B1 (enrdf_load_stackoverflow) | 1973-07-13 |
| NL7009390A (enrdf_load_stackoverflow) | 1971-01-12 |
| ZA704157B (en) | 1972-01-26 |
| FR2059503A1 (enrdf_load_stackoverflow) | 1971-06-04 |
| DE2034139A1 (de) | 1971-02-04 |
| JPS5220463B1 (enrdf_load_stackoverflow) | 1977-06-03 |
| US3714229A (en) | 1973-01-30 |
| DK138418B (da) | 1978-09-04 |
| AU1710070A (en) | 1972-01-06 |
| BR6914798D0 (pt) | 1973-03-08 |
| IL34831A0 (en) | 1970-09-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |