GB1266566A - - Google Patents

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Publication number
GB1266566A
GB1266566A GB1266566DA GB1266566A GB 1266566 A GB1266566 A GB 1266566A GB 1266566D A GB1266566D A GB 1266566DA GB 1266566 A GB1266566 A GB 1266566A
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United Kingdom
Prior art keywords
alkyl
compounds
group
prepared
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
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Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication of GB1266566A publication Critical patent/GB1266566A/en
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/36—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/17—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings containing other rings in addition to the six-membered aromatic rings, e.g. cyclohexylphenol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/41—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrogenolysis or reduction of carboxylic groups or functional derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
    • C07C47/47—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/39—Unsaturated compounds containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/017—Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/753—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/44—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing eight carbon atoms

Abstract

1,266,566. Bicyclooctane-carboxylic acid derivatives. E. I. DU PONT DE NEMOURS & C O . 23 April, 1969 [23 April, 1968; 24 Feb., 1969], No. 20855/69. -Heading C2C. Novel compounds I wherein two of the A's are single bonds and the other is a single or double bond or if Y is COOalkyl two of the A's are double bonds and the other is a single bond; R 1 -R 4 are H, F, Cl, Br, 1-12 C alkyl, provided (a) that R 1 -R 4 together contain not more than 16 C (b) at least one of R 1 -R 4 is alkyl and (c) not more than two of R 1 -R 4 are halo and that when two are halo they are adjacent to the same A; X is H, OH, OCOR<SP>6</SP>, (R 6 is H or 1-12 C alkyl), 0R 5 (R 5 is 1-6 C alkyl), 3-6 C cycloalkyl, 2-tetrahydropyrenyl or -CH 2 OCH 3 ; Y is -CHO, a group hydrolysable to -CHO, -COOR 7 (R 7 is H, 1-12 C alkyl, tetrahydropyranyl or a cation) -CH 2 OR 8 (R8 is H, hydrolysable esterifying group or an ether forming group) or COR 9 (R 9 is NHOH, NR 10 R 11 or NHNR 10 R 11 ; R 10 and R 11 are H, CH 3 , C 2 H 5 or C 3 H 7 or NR 10 R 11 is pyrrolidino, piperidino or morpholino) and R 12 is H, F, Cl, Br or CH 3 are prepared by (a) reducing a suitable compound I wherein one of R 1 - R 4 is an acyl group to give I where all A's are single bonds and at least one of R 1 to R 4 is a 2-12 C alkyl group; (b) reacting a compound II with a compound III wherein R 7 is 1-12 C alkyl and A is a single or double bond followed where necessary by reduction of compounds I where more than one A is a double bond; and (c) converting any group X or Y into another group X or Y by methods known per se. Intermediates isolated are compounds IV which are prepared by reaction of an appropriate alkyl phenyl ketone and an alkoxymeth. yiene-malonic acid diester; compounds II which are prepared by reaction of compounds IV with compounds R 3 -CH = CH-R 4 and the compounds used as starting materials in process (a) above which are prepared in a similar manner to compounds II. Pharmaceutical compositions useful in the prevention of pregnancy comprise a compound I together with a suitable carrier for oral administration.
GB1266566D 1968-04-23 1969-04-23 Expired GB1266566A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72359668A 1968-04-23 1968-04-23
US80185769A 1969-02-24 1969-02-24

Publications (1)

Publication Number Publication Date
GB1266566A true GB1266566A (en) 1972-03-15

Family

ID=27110827

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1266566D Expired GB1266566A (en) 1968-04-23 1969-04-23

Country Status (8)

Country Link
BE (1) BE731393A (en)
BR (1) BR6908291D0 (en)
DE (1) DE1920241A1 (en)
FR (1) FR2007497A1 (en)
GB (1) GB1266566A (en)
IL (1) IL31863A0 (en)
LU (1) LU58432A1 (en)
NL (1) NL6906189A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987002995A1 (en) * 1985-11-08 1987-05-21 Exfluor Research Corporation The pyrolysis of perfluoropolyethers

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1472947A (en) * 1964-06-22 1967-03-17 Du Pont Bicyclo [2, 2, 2] -octenes and their preparation
BE664913A (en) * 1965-06-04

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987002995A1 (en) * 1985-11-08 1987-05-21 Exfluor Research Corporation The pyrolysis of perfluoropolyethers

Also Published As

Publication number Publication date
DE1920241A1 (en) 1969-11-06
FR2007497A1 (en) 1970-01-09
LU58432A1 (en) 1969-07-21
IL31863A0 (en) 1969-05-28
BR6908291D0 (en) 1973-02-08
BE731393A (en) 1969-10-13
NL6906189A (en) 1969-10-27

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee